How to heighten the curative effect of interferon?

Guideline of prevention and cure of liver of Chinese chronic second comes on stage more than one year, people cognizant fights virus to treat namely to the standard treatment of chronic second liver, fight virus cure to also have two kinds of plan only, one kind is interferon cure, analogue of a kind of nucleotide is treated. Decide period of treatment and virus mutation than latter inaccuracy, risk of the remedial period of treatment that because its are secured,interferon treats, poisonous without disease mutation and long-term curative effect and the central point that makes second liver domain pay close attention to for a time, however, the short-term curative effect of interferon is smaller the bad-mouth that also calls authority, 2007 on the liver ill forum of New Year beginning, numerous expert discussed actively also how to raise interferon, get together especially glycol interferon α - the curative effect of 2a. Presider is: Australia Bulisi the class is royal hospital Graham Cooksley, participate in discussion expert to basically have: 302 hospital Professor Zhang Hongfei professors of hospital of Beijing ground altar Professor Xu Daozhen, Beijing, China medical university is accessary Chen Xin month teachs hospital of altar of ground of the 2nd hospital Professor Dou Xiaoguang, Beijing and Shanghai is communal and wholesome central witch be apt to. Raising interferon to treat the curative effect field of second liver, each expert thinks the following is very important consistently: 1. The optimal opportunity 　 that chooses treatment although liver of interferon cure second has its distinct advantage, but not be everybody suits interferon to treat, also not be the effect that everybody has interferon is treated identical, accordingly, the remedial opportunity with equal choice is very significant. Immunity is cleared period the optimal opportunity that is cure of interferon disease-resistant poison, and also can obtain best remedial result. Transaminase (ALT) is in go up somehow can struggle between system of reflective airframe immunity and virus state, often state when transaminase is elevatory airframe immunity system is keeping clear of virus, perhaps say to be in cleared period, accordingly, normally clinical go up to basically pass observation transaminase (when does the metabolic decision of ALT) level undertake interferon disease-resistant poison is treated more appropriate. Generally speaking, transaminase is taller, the effect of interferon disease-resistant poison is taller also. Common law is 5 times what ALT> is worth normally, e antigen (rate of HBeAg) serological changeover can be achieved 50% , ALT is in the times E of 2~5 of normal value antigen is serological changeover rate can be achieved 38% , ALT 　 　 2. Lengthen 　 of period of treatment to get together liver of second of glycol interferon cure, get together glycol interferon α - 2a treats excel of 48 weeks of period of treatment 24 weeks of period of treatment, additional, in the respect of cure that monitor, in treating a process E antigen ration monitors serological to monitoring E antigen changeover to lead HBV DNA more valuable, the patient of serological to producing E antigen changeover undertakes exterior antigen (HBsAg) ration is monitored conduce to judgement obtaining exterior antigen whether possibly (HBsAg) serological changeover. Respondent to treating 48 weeks to obtain HBV DNA, but the patient that E antigen has not produced serological changeover lengthens cure to whether can achieve E antigen serological changeover, perhaps obtain E antigen it is OK that the patient of serological changeover continues to treat raise exterior antigen (rate of HBsAg) serum changeover still remains further research and longer observation. 3. Jointly / although current a few research think,order follow in a continuous line treats 　 , the plan that glycol interferon and nucleotide analogue get together jointly in the meantime can not raise E antigen serological changeover rate, but order follow in a continuous line treats plan, use interferon to improve airframe immunity function first especially, follow-up combination therapy may heighten curative effect, and can consider to combine cure to the patient of level of tall HBV DNA before cure, in addition associated therapy may reduce nucleotide kind the virus mutation rate of medicaments, because this is right,combination and the effectiveness that order follow in a continuous line treats still need to undertake further extensive research is discussed. 4. Raise comply with sex, reasonable processing is undesirable reaction 　 gets together glycol interferon α - the conference when 2a is treated appears a few harmful response, the commonnest is blood picture change, if neuter bead cell decreases, if deputy reaction processing is undeserved, or comply with sex of the patient is lower, stop drug blindly, with respect to effect of very inaccessible favorable treatment. Actually, these harmful response basically appear in remedial initial stage, be in commonly 4 fall inside week to lowest, stabilize after that at this one level, after stopping drug, can restore. The neuter bead cell in treating a process decreases to be measured through be being decreased appropriately, lengthen use interval, do not need to stop drug commonly, great majority patient can overshoot. It is the substantial that chronic second liver treats to the proper understanding of harmful response and reasonable processing. Conduce to raise sex of patient comply with. And of interferon enough expose a quantity to be able to heighten clinical curative effect effectively. But in interferon use process. If need of change of thyroid gland function discovers in time and harmful to oneself immunity response undertakes be handlinged effectively. Brief summary 　 is in clinical practice, use get together glycol interferon α - when 2a treats patient of liver of second of E antigen positive, ought to treat an opportunity suitably through the choice, lengthen period of treatment, order follow in a continuous line or associated therapy and the effective processing to harmful response come individual change the ground to heighten clinical curative effect, strive for achieve E antigen serological changeover, later according to exterior antigen (whether does HBsAg) ration drop as a result will consider to whether strive for exterior antigen (HBsAg) serological changeover. (the exercitation edits: Plum apricot)

The liver that fight second suffers a dot do not matter

Current, poison of normal second liver disease-resistant treats medicaments, only two is plant -- interferon and nucleotide analogue, both each have actor drawback. The patient's situation is different, the choice of medicaments is different also, if young, near future has birth demand, and the person that the hope ends cure inside shorter time, can consider interferon treatment above all. Use interferon is treated, curative effect is lasting, be in " big 3 this world " in patient of chronic second liver, occurence rate of HbeAg serum changeover is higher; and, more the opportunity that hopeful gains the surface to antigen keeps clear of and be changed. Nevertheless, if choose interferon treatment, the doctor can tell a patient: "You should suffer a dot possibly " . Because, no matter use common interferon or lasting effect interferon (be like: Get together glycol changes interferon α - 2a) , 90% right-and-left patients can appear harmful response, this and its action mechanism (can adjust airframe immunity) about. "Cold " , need not handling the harmful response with the commonnest 　 more is kind of flu symptom, occurence rate is 70% ～ 80% . The patient is injecting 24 hours after the 1st needle normally inside, appear calorific, temperature can amount to 38 ～ 39 Celsius, but exceed 40 Celsius rarely, can accompany have have a headache, muscle ache, articulatory ache, lack of power etc. If do not exceed 38 Celsius, doctor proposal patient waters more and rest when; should exceed 38 Celsius or the patient feels afflictive, give a few solution hot demulcent drug, be like Le Song or 100 take clever, can eat first. Over- one week later when the 2nd needle, the symptom is reduced somewhat normally, and when hit the 3rd needle when, the symptom disappears basically. Investigator thinks, this is interferon brought what system of human body immunity participates in second liver virus into play actually " battle " hind, a few symptoms that the body reacts intense place is caused, reason need not notice overly. Medullary " restrain " , not be to answer thing 　 leucocyte or plaque to decrease then more also see, in the head normally 8 weeks appear, also some meetings end to cure continuously. Most patient does not have self-conscious symptom, the small number of people is haemorrhage of meeting occurrence gum, giddy, lack of power wait for a symptom. Accordingly, regular examination is very important, when before be being hit especially two needles, should check hematic convention and liver function. A lot of people feel fear, think this and the marrow that change cure to cause are restrained similar, actually otherwise. Interferon is done not have certain the cellular noxiousness of the medicine that change cure, amount of this kind of leucocyte decreases cross a gender. Of course, if the neuter bead cell in leucocyte is absolutely,computation rises less at 1 × 10(9) / , or plaque rises less at 50 × 10(9) / , the doctor can make corresponding processing, if use litre of leucocyte drug, adjust interferon dosage to stop drug even. Reason patient need not be in a state of anxiety, should observe closely only can. Trichomadesis is false appearance, lose one's hair of more important 　 is treating the mood normally later period appears. Some patients, especially girl, mind this very much. Actually, if change the lose one's hair of cure be caused by,this is not, is the hair falls off only relatively at ordinary times a bit much just, discover when shampoo or do up one's hair more, the patient can be at ease, trichomadesis phenomenon is temporary, also won't appear bald. Nevertheless, wanting those who warn a family member is, should pay close attention to the patient's mood. Interferon can cause mind unusual, although occurence rate is extremely low, but the patient is appearing when the symptom such as depressed, covet, angst, oneself is not aware of certainly. So, the consideration of family is very serious, answer to maintain good communication with the doctor. Patient and doctor resemble athlete and coach, be in cure card of this gold nugget to capture and try hard, meantime hard to avoid should be paid " blood and sweat " , but should believe to be met sooner or later after suffering comes happiness. In interferon cure obtains E antigen to turn after shade, its recrudesce probability is small, maintain curative effect time to grow; to occupy data story, use get together glycol changes interferon α - 2a cure stops drug after 1 year, in following the patient that visits 4 years, exterior antigen turns the number of shade is occupied 11% . Although this proportion is not high, but offer a patient certain hope, raised remedial hope. The project 　 that the examination wants before cure chooses interferon treatment, the patient checks hematic convention besides need, in order to know leucocyte level outside, sift even check disease of immunity of a few oneself, wait like lupus erythematosus of Jia Kang, diabetic, rheumatoid arthritis, system, because the hurried immunity of interferon adjusts,action can cause these diseases. In the meantime, had better look for doctor of liver ill specialized subject to be opposite at present second liver illness undertakes be assessmented integratedly, it is normal in if diagnose,be that total bilirubin of terminal liver cirrhosis, heavy-duty hepatitis or serum exceeds value upper limit 2 times above, do not suit to use interferon to treat. (the exercitation edits: Plum apricot)

Disease-resistant bane content who can gain the championship?

We know, the medicaments of virus of the liver that fight second has two large new force -- interferon and nucleotide (acerbity) analogue. So, what characteristic does content of bane of two kinds of big disease-resistant have? If contrast them, what good qualities and fault do they have again severally? A lot of people do not understand this. Of action mechanism contend for virus of liver of the second inside system of patient of liver of 　 chronic second to duplicate to be opposite with airframe continuously the iteration of virus immunity is cleared, cause chronic loss to liver. The fight of second liver virus and system of human body immunity formed seesaw battle. Be based on this kind of circumstance, people defies second liver virus has two strategy, it is to let the ability with duplicate virus be restrained, 2 it is to make airframe immunity cleared capability is again a few stronger. ● interferon and nucleotide (acerbity) analogue has the effect that restrains virus to duplicate. ● interferon holds concurrently restrain virus and raise airframe immunity the action of cleared ability. Among them, lasting effect interferon -- get together trade name of glycol interferon A-2a(: Send Luo Xin) the effect is better, it already was supervised by American food medicines and chemical reagents management board (the country such as FDA) , European Union and China and area approval use Yu Yi liver to treat. The nucleotide of ● of the 　 that contend for 　 of the advantage (acerbity) analogue controls capacity of second liver virus strong, apply to the patient such as cirrhosis of all sorts of chronic second liver, liver, profess to convinced is convenient. The HBV after cure is duplicate can get inhibition quickly. ● and nucleotide (acerbity) analogue photograph is compared, inside the period of treatment that controls 1 year, via getting together glycol interferon A-2a(sends Luo Xin) cure, the proportion that E antigen change is E antibody is higher (afore-mentioned transition abbreviation are medical admiral E antigen serum changes) , mean a disease to get controlling, antigen of surface of liver of second of the person that minority is treated can disappear even, and young patient use effect is better. Nucleotide of ● of 　 of 　 of defect show up one's fault (acerbity) rate of changeover of serum of analogue E antigen is lower, need long-term treatment, stop medical hind to have a relapse easily. Long-term application can happen be able to bear or endure medicine mutates, if rummy husband decides revulsive second liver virus to be able to bear or endure,medical mutation happens early and occurence rate is high, approve use nucleotide recently (acerbity) although analogue reports be able to bear or endure medical occurence rate is low, but still need farther observation. ● interferon needs subcutaneous injection, common interferon a week should inject 3 times, lasting effect interferon gets together glycol interferon A-2a also wants a week to inject. Use interferon side effect is apparent, if appear flu appearance symptom, all round the demote below blood picture, via be treated to disease or stopping medical hind to be able to restore by oneself. The price is higher one of defect that also are this kind of medicaments. Of curative effect contended for 　 to see the comparison above, so curative effect of which kinds of drug is good? Actually, medicaments curative effect is good depend on medicaments and the person that use is individual circumstance two main factors. ● gets together glycol interferon A-2a(sends Luo Xin) the dominant position is changed in blood of E antigen serum period of treatment of strong, cure is clear, and won't happen bounce stopping drug and be able to bear or endure medicine mutates, it is the good choice that person and young patient treat a disease first. But its price is high, have certain side effect, some patients cannot insist to complete period of treatment, the curative effect that expects with respect to short of in that way. Some patients bear hard, the curative effect that expects with respect to short of in that way. ● nucleotide (acerbity) analogue restrains virus effectively, and take convenient, but remedial time is longer than interferon, emphasize managing treatment. The person that already produced the chronic second liver of liver cirrhosis, be like a nucleotide (acerbity) analogue (if rummy husband is decided) lifelong like hypertensive, diabetic medicaments take, very easy and revulsive virus is able to bear or endure medicine mutates, bring difficulty to follow-up cure. Remedial opportunity and remedial goal are consistent 　 although two kinds of medicaments exist many difference, but in when can undertake disease-resistant poison is treated () of disease-resistant poisonous opportunity, and when to calculate achieved remedial goal (treat terminal) , these two respects are consistent. ● disease-resistant poisonous opportunity has those transaminase prep above to be worth upper limit 2~10 normally only times, coexist in HBVDNA the talent of a large number of duplicate evidence suits disease-resistant poison to treat. Choose poison of this opportunity disease-resistant, the reason depends on airframe immunity system having to virus dynamic the ground revolts, immune system was brought into play adequately to rise, achieve better curative effect with medical general at that time. No matter patient of ● cure terminus accepts the treatment of which kinds of medicine, should detect second liver two half-and-half when index, if E antigen disappears, E antibody appears, can regard as achieve clinical admissive treatment is terminal. But achieve remedial terminus and do not mean should stop drug instantly, clinical go up to still can undertake one Duan Gong solid is treated commonly, especially nucleotide (acerbity) analogue, still can do 6~12 commonly of the month consolidate cure. Medical bound is trying two medicine to treat 　 international and home to trying interferon and nucleotide jointly (acerbity) analogue treats chronic second liver jointly, but whether can heighten curative effect, or have how old rate rises curative effect, still need to have more clinical basises. (the exercitation edits: Plum apricot)

Disease-resistant bane content who can gain the championship?

We know, the medicaments of virus of the liver that fight second has two large new force -- interferon and nucleotide (acerbity) analogue. So, what characteristic does content of bane of two kinds of big disease-resistant have? If contrast them, what good qualities and fault do they have again severally? A lot of people do not understand this. Of action mechanism contend for virus of liver of the second inside system of patient of liver of 　 chronic second to duplicate to be opposite with airframe continuously the iteration of virus immunity is cleared, cause chronic loss to liver. The fight of second liver virus and system of human body immunity formed seesaw battle. Be based on this kind of circumstance, people defies second liver virus has two strategy, it is to let the ability with duplicate virus be restrained, 2 it is to make airframe immunity cleared capability is again a few stronger. ● interferon and nucleotide (acerbity) analogue has the effect that restrains virus to duplicate. ● interferon holds concurrently restrain virus and raise airframe immunity the action of cleared ability. Among them, lasting effect interferon -- get together trade name of glycol interferon A-2a(: Send Luo Xin) the effect is better, it already was supervised by American food medicines and chemical reagents management board (the country such as FDA) , European Union and China and area approval use Yu Yi liver to treat. The nucleotide of ● of the 　 that contend for 　 of the advantage (acerbity) analogue controls capacity of second liver virus strong, apply to the patient such as cirrhosis of all sorts of chronic second liver, liver, profess to convinced is convenient. The HBV after cure is duplicate can get inhibition quickly. ● and nucleotide (acerbity) analogue photograph is compared, inside the period of treatment that controls 1 year, via getting together glycol interferon A-2a(sends Luo Xin) cure, the proportion that E antigen change is E antibody is higher (afore-mentioned transition abbreviation are medical admiral E antigen serum changes) , mean a disease to get controlling, antigen of surface of liver of second of the person that minority is treated can disappear even, and young patient use effect is better. Nucleotide of ● of 　 of 　 of defect show up one's fault (acerbity) rate of changeover of serum of analogue E antigen is lower, need long-term treatment, stop medical hind to have a relapse easily. Long-term application can happen be able to bear or endure medicine mutates, if rummy husband decides revulsive second liver virus to be able to bear or endure,medical mutation happens early and occurence rate is high, approve use nucleotide recently (acerbity) although analogue reports be able to bear or endure medical occurence rate is low, but still need farther observation. ● interferon needs subcutaneous injection, common interferon a week should inject 3 times, lasting effect interferon gets together glycol interferon A-2a also wants a week to inject. Use interferon side effect is apparent, if appear flu appearance symptom, all round the demote below blood picture, via be treated to disease or stopping medical hind to be able to restore by oneself. The price is higher one of defect that also are this kind of medicaments. Of curative effect contended for 　 to see the comparison above, so curative effect of which kinds of drug is good? Actually, medicaments curative effect is good depend on medicaments and the person that use is individual circumstance two main factors. ● gets together glycol interferon A-2a(sends Luo Xin) the dominant position is changed in blood of E antigen serum period of treatment of strong, cure is clear, and won't happen bounce stopping drug and be able to bear or endure medicine mutates, it is the good choice that person and young patient treat a disease first. But its price is high, have certain side effect, some patients cannot insist to complete period of treatment, the curative effect that expects with respect to short of in that way. Some patients bear hard, the curative effect that expects with respect to short of in that way. ● nucleotide (acerbity) analogue restrains virus effectively, and take convenient, but remedial time is longer than interferon, emphasize managing treatment. The person that already produced the chronic second liver of liver cirrhosis, be like a nucleotide (acerbity) analogue (if rummy husband is decided) lifelong like hypertensive, diabetic medicaments take, very easy and revulsive virus is able to bear or endure medicine mutates, bring difficulty to follow-up cure. Remedial opportunity and remedial goal are consistent 　 although two kinds of medicaments exist many difference, but in when can undertake disease-resistant poison is treated () of disease-resistant poisonous opportunity, and when to calculate achieved remedial goal (treat terminal) , these two respects are consistent. ● disease-resistant poisonous opportunity has those transaminase prep above to be worth upper limit 2~10 normally only times, coexist in HBVDNA the talent of a large number of duplicate evidence suits disease-resistant poison to treat. Choose poison of this opportunity disease-resistant, the reason depends on airframe immunity system having to virus dynamic the ground revolts, immune system was brought into play adequately to rise, achieve better curative effect with medical general at that time. No matter patient of ● cure terminus accepts the treatment of which kinds of medicine, should detect second liver two half-and-half when index, if E antigen disappears, E antibody appears, can regard as achieve clinical admissive treatment is terminal. But achieve remedial terminus and do not mean should stop drug instantly, clinical go up to still can undertake one Duan Gong solid is treated commonly, especially nucleotide (acerbity) analogue, still can do 6~12 commonly of the month consolidate cure. Medical bound is trying two medicine to treat 　 international and home to trying interferon and nucleotide jointly (acerbity) analogue treats chronic second liver jointly, but whether can heighten curative effect, or have how old rate rises curative effect, still need to have more clinical basises. (the exercitation edits: Plum apricot)

Disease-resistant bane content who can gain the championship?

We know, the medicaments of virus of the liver that fight second has two large new force -- interferon and nucleotide (acerbity) analogue. So, what characteristic does content of bane of two kinds of big disease-resistant have? If contrast them, what good qualities and fault do they have again severally? A lot of people do not understand this. Of action mechanism contend for virus of liver of the second inside system of patient of liver of 　 chronic second to duplicate to be opposite with airframe continuously the iteration of virus immunity is cleared, cause chronic loss to liver. The fight of second liver virus and system of human body immunity formed seesaw battle. Be based on this kind of circumstance, people defies second liver virus has two strategy, it is to let the ability with duplicate virus be restrained, 2 it is to make airframe immunity cleared capability is again a few stronger. ● interferon and nucleotide (acerbity) analogue has the effect that restrains virus to duplicate. ● interferon holds concurrently restrain virus and raise airframe immunity the action of cleared ability. Among them, lasting effect interferon -- get together trade name of glycol interferon A-2a(: Send Luo Xin) the effect is better, it already was supervised by American food medicines and chemical reagents management board (the country such as FDA) , European Union and China and area approval use Yu Yi liver to treat. The nucleotide of ● of the 　 that contend for 　 of the advantage (acerbity) analogue controls capacity of second liver virus strong, apply to the patient such as cirrhosis of all sorts of chronic second liver, liver, profess to convinced is convenient. The HBV after cure is duplicate can get inhibition quickly. ● and nucleotide (acerbity) analogue photograph is compared, inside the period of treatment that controls 1 year, via getting together glycol interferon A-2a(sends Luo Xin) cure, the proportion that E antigen change is E antibody is higher (afore-mentioned transition abbreviation are medical admiral E antigen serum changes) , mean a disease to get controlling, antigen of surface of liver of second of the person that minority is treated can disappear even, and young patient use effect is better. Nucleotide of ● of 　 of 　 of defect show up one's fault (acerbity) rate of changeover of serum of analogue E antigen is lower, need long-term treatment, stop medical hind to have a relapse easily. Long-term application can happen be able to bear or endure medicine mutates, if rummy husband decides revulsive second liver virus to be able to bear or endure,medical mutation happens early and occurence rate is high, approve use nucleotide recently (acerbity) although analogue reports be able to bear or endure medical occurence rate is low, but still need farther observation. ● interferon needs subcutaneous injection, common interferon a week should inject 3 times, lasting effect interferon gets together glycol interferon A-2a also wants a week to inject. Use interferon side effect is apparent, if appear flu appearance symptom, all round the demote below blood picture, via be treated to disease or stopping medical hind to be able to restore by oneself. The price is higher one of defect that also are this kind of medicaments. Of curative effect contended for 　 to see the comparison above, so curative effect of which kinds of drug is good? Actually, medicaments curative effect is good depend on medicaments and the person that use is individual circumstance two main factors. ● gets together glycol interferon A-2a(sends Luo Xin) the dominant position is changed in blood of E antigen serum period of treatment of strong, cure is clear, and won't happen bounce stopping drug and be able to bear or endure medicine mutates, it is the good choice that person and young patient treat a disease first. But its price is high, have certain side effect, some patients cannot insist to complete period of treatment, the curative effect that expects with respect to short of in that way. Some patients bear hard, the curative effect that expects with respect to short of in that way. ● nucleotide (acerbity) analogue restrains virus effectively, and take convenient, but remedial time is longer than interferon, emphasize managing treatment. The person that already produced the chronic second liver of liver cirrhosis, be like a nucleotide (acerbity) analogue (if rummy husband is decided) lifelong like hypertensive, diabetic medicaments take, very easy and revulsive virus is able to bear or endure medicine mutates, bring difficulty to follow-up cure. Remedial opportunity and remedial goal are consistent 　 although two kinds of medicaments exist many difference, but in when can undertake disease-resistant poison is treated () of disease-resistant poisonous opportunity, and when to calculate achieved remedial goal (treat terminal) , these two respects are consistent. ● disease-resistant poisonous opportunity has those transaminase prep above to be worth upper limit 2~10 normally only times, coexist in HBVDNA the talent of a large number of duplicate evidence suits disease-resistant poison to treat. Choose poison of this opportunity disease-resistant, the reason depends on airframe immunity system having to virus " dynamic " the ground revolts, immune system was brought into play adequately to rise, achieve better curative effect with medical general at that time. No matter patient of ● cure terminus accepts the treatment of which kinds of medicine, should detect " second liver two half-and-half " when index, if E antigen disappears, E antibody appears, can regard as achieve clinical admissive treatment is terminal. But achieve remedial terminus and do not mean should stop drug instantly, clinical go up to still can undertake one Duan Gong solid is treated commonly, especially nucleotide (acerbity) analogue, still can do 6~12 commonly of the month consolidate cure. Medical bound is trying two medicine to treat 　 international and home to trying interferon and nucleotide jointly (acerbity) analogue treats chronic second liver jointly, but whether can heighten curative effect, or have how old rate rises curative effect, still need to have more clinical basises. (the exercitation edits: Plum apricot)

Vigilant: Not by " second liver turns shade " give muddled

Can be chronic hepatitis B effected a radical cure? To adult acute hepatitis B, great majority patient is OK self-healing (it is good to spend period of time like the cold) , final symptom disappears, liver function returns to normal, serum HBsAg disappears, serum HBsAb positive indicates second liver virus is kept clear of, this part person can say to obtain effect a radical cure. However at present socially patient of liver of great majority second is chronic second liver, cure for a long time hard. Actually chronic hepatitis B still is a kind of disease that cannot cure up to now, no matter be home or abroad, no matter be Chinese traditional medicine or Western medicine, still can make chronic hepatitis B complete without a kind of medicines and chemical reagents heal. The reason that chronic second liver cures hard basically has the following kinds: Above all, parasitism of second liver virus is inside the cell, besides liver cell, medullary, bile duct, pancreatic, kidney and lymphocyte are OK parasitism, duplicate, the virus inside the organization is kept clear of not easily, become one of recrudescent matters. Next, HBVDNA and recrudescent relationship are close: The covalence inside liver nucleolus is cricoid close DNA (CccDNA) it is duplicate pattern plate, current and clinical on commonly used interferon and rummy husband all cannot keep clear of surely the CccDNA inside nucleolus, then once out of service fights virus medicaments, the CccDNA inside consist in nucleolus serves as duplicate pattern plate, new transcribe is duplicate. If produce HBVDNA and conformity of body cell DNA, likewise integrated HBVDNA cannot be kept clear of, this also is the reason of a kind of recrudesce. Still have the immune function state that a reason is a patient, immunity is cleared dissident, second liver virus is not the component of airframe oneself, the immune cell of airframe is about to identify, cleared it, but the immune function of patient of liver of most slow second is diseased, be in immunity to be able to bear or endure suffer or immune function is low, cannot develop the function of cleared virus well so. How proper understanding " of second liver turn shade " cure? At present " second liver turns shade " it is to show serum HBeAg or HBVDNA shade turn commonly, HBsAb this world turns (HBeAg turns at the same time companion has back HBsAb appears call " serum is changed " ) . HBeAg, HBVDNA appears in blood virus of reflective second liver is duplicate inside liver cell active, of serum HBeAg, HBVDNA disappear virus of reflective second liver is duplicate tend dormant. If send area of the C before unripe virus,mutate of course, at this moment although blood is medium,HBeAg does not appear, however virus duplicates is active however, detect below this kind of circumstance hematic HBVDNA often is masculine gender. So HBVDNA is virus of reflective second liver is duplicate " golden index " , and the ration that had better undertake HBVDNA detects, conduce to the choice that treats plan and the judgement that combat virus curative effect. Virus duplicates to often be mixed inflammation activity is relevant, disease-resistant poison cure gives to be able to make an illness restore quickly in opportune opportune moment, the inflammation that improves liver organization and necrotic, thereby can the progress of slow down illness, duplicate to a few virus so active and liver has the patient of inflammation to undertake disease-resistant poison treats dispute to often have active sense. But HBeAg, HBVDNA shade turns to meant airframe to already kept clear of thoroughly anything but virus, although blood is medium nonexistent virus, second liver virus still but inside the liver cell of consist in patient, must be clear about at this o'clock. HBVDNA of the blood after use disease-resistant poison is treated shade turns to appear at the same time " serum is changed " these patients compare pure HBVDNA chance of recrudesce of the person that shade turns and HBeAg shade turns is little. As to make HBsAg of serum of patient of chronic hepatitis B turns shade is impossible almost. Emphasize making with all sorts of medicaments blindly second liver virus each index shade turns, with period cure thoroughly, essential short of this kind of curative effect, and because use medicine to be able to accentuate instead in great quantities hepatic burden, bring about liver of sex of patient occurrence medicaments to damage. Disease-resistant poison cure must master strictly get used to disease because 　 is current poisonous to the disease-resistant of chronic hepatitis B cure still does not have curative effect to reach the remedial method that effects a radical cure completely really, add patient of broad second liver to reach its to treat the current situation not to understand to the basic knowledge of second liver, and they beg the mood with pressing cure, partial medical establishment and businessman seek commercial profit one-sidedly, make the current situation that at present disease-resistant poison treats more confused, the medicaments of all sorts of items emerges in endlessly. More a few all corners of the country swim cure exploit an advantage is hit all sorts of alleged " turn shade " medicine, the patient one disaster after another that this torments to times liver getting second not only, righter limited medical treatment natural resources creates enormous waste. To chronic second the cure of liver should make clear what patient to need disease-resistant poison to treat above all, what patient still does not need disease-resistant poison to treat temporarily. When virus of chronic second liver is affected, virus became much do not appear certainly serious liver is damaged, virus became little not certain also liver is damaged light. Ill to second liver hair mechanism considers to make clear, airframe immunity system is respondent to immunity of generation of second liver virus it is the main factor that causes liver to damage, if behave positive of index of virus of the liver that it is second merely, liver does not have apparent inflammation loss, liver function is normal, we call the person that second liver virus is carried, this kind of patient no matter virus amount how many, at present consensus of the expert on international thinks to be able to be not treated temporarily, need to maintain not good state of mind, abstinence, excessive exhaustion only, do not use caustic liver remedy, every half an year checks liver function and B to exceed to the hospital. Vivid check of liver of travel of the person that if be opposite,second liver virus is carried, discover the person that there is apparent inflammation inside liver, to prevent these patients rapid development is liver cirrhosis and liver cancer, can consider to undertake disease-resistant poison is treated. The patient of chronic second liver that needs treatment basically is to show those liver are damaged apparent, the patient with liver disease rapidder progress, remedial target is to reduce liver cell loss, protect hepatic function, it is normal that the hepatic function that allows a patient is maintained basically, maintain its all one's life not to appear liver function fails. Duplicate to certain virus active, liver damages apparent patient to be able to consider to give disease-resistant poisonous treatment. Cure should be in next professional doctor is directive undertaking that content of 　 disease-resistant bane has certain undesirable reaction, some patients can appear calorific, have a headache, bald hair, depressed, leucocyte drops, the demote below appetite, among the process that in application so disease-resistant bane content has remedial, must ask to check liver function to the hospital regularly by the doctor, monitor the harmful response of likelihood happening closely, facilitate seasonable discovery and processing, lest cause serious consequence. The patient that uses interferon for example should have the examination of hematic convention regularly, with preventing to appear serious marrow is restrained, 3000 need of WBC ＜ stop medical observation; Use the patient that rummy husband decides for a long time, the second liver virus inside body can produce mutation (YMDD mutates) , this kind of mutation can bring about what second liver virus decides to rummy husband to be able to bear or endure medicine, a few patient returns the wave motion of meeting occurrence illness or accentuation, inchoate discovery the meaning with YMDD conclusive to treating the adjustment of plan to have mutation. The patient that takes Adefuwei should check regularly kidney function. Because some patients fear to go up hospital proper motion seeing a doctor buys drug in drugstore " autonomy " , think can replace the disease-resistant bane matter that taking temporarily, this kind of practice also is wrong. Appeal doctor of specialized subject of hospital of Yu Zheng compasses just is second liver patient those who see a doctor " correct path " , they can understand hepatic situation with all sorts of necessary examinations, be aimed at different illness, different level, use different integrated remedy. See a doctor to still can prevent the disease-resistant bane thing with fake misapplication in office of doctor of normal hospital specialized subject. (the exercitation makes up arrest: Plum apricot)

How did the child get hepatitis to do?

Virus sex hepatitis, especially chronic noxiousness hepatitis B and third hepatitis, it is the disease that endangers children health badly. Because children is hepatic more opposite than growing up bigger, blood is offerred rich, liver rejuvenesce capability is strong, but immune system is immature, immunity of easy to the hepatitis virus that inbreak generation is able to bear or endure suffer, accordingly, after children contracts hepatitis virus make chronic patient easily, affect than growing up if really ever since more serious, the harm also is gotten greatly much. After contracting second liver virus like the adult, 95% above can restore completely, only a few translate into carries virus condition or; of chronic second liver chronically and after virus of liver of children infection second, if not seasonable cure or cure are undeserved, 90% meetings development is 80% ～ to carry virus condition or chronic second liver chronically. In fact, the adult that clinical place sees is chronic hepatitis majority originates children period infection. Additional, after children contracts hepatitis virus, produce liver fiber to change, liver is sclerotic even the rate of liver cell cancer is higher also. Can so say, children hepatitis is his the early days phase of cirrhosis of adulthood occurrence liver, liver cancer. Accordingly, hepatitis of children virus sex should cause the height of people to take seriously, give seasonable, scientific cure. In children hepatitis, hepatitis B holds great majority, change of pathology of its biochemistry index, liver also differ somewhat with the adult. Like children chronic second liver often does not have a symptom or the symptom is slight, liver function (basically be transaminase) normal slight perhaps change, but liver pathology examination shows liver has mobile sex inflammation or fiber is changed possibly however form. According to the near future our statistic, the little patient of chronic second liver that pathology examination confirms to liver organization has apparent inflammation, about 41% because liver function is normal by by accident examine receives seasonable treatment to be done not have without the person that the symptom is carried. This explains, liver function is not equal to liver to do not have mobile sex inflammation normally. Usually, virus of chronic second liver affects a little patient to should undertake medicine observes regularly, like every other 6 months go to 3 ～ liver function of hospital laboratory test, HBV-DNA. If liver function has positive of unusual, HBV-DNA, want to undertake disease-resistant poison is treated in time. If liver function is normal all the time, but the little patient has apparent symptom and body to ask for, if unwell, liver increases area of lack of power, angular, liver,wait for a circumstance, suggest liver pathology examination, understanding liver has inanimation sex inflammation or fiber is changed, so that discover a problem in time, seize favorable remedial opportunity. The person that travel because of Mu Ying especially and affect 4 years old before, should undertake liver pathology is checked more. Some people think blindly, as long as " bay fight " masculine gender should be treated, or want transaminase not to need treatment normally only, this is to be mixed one-sidedly unscientific. Actually, want liver to have mobile sex pathological change only, mobile sex virus duplicates, it is to fight what virus treats to point to proof. Domestic and international expert thinks consistently, observation combats the curative effect of virus medicaments, the near future curative effect when including period of treatment to end not only (liver function restores serum of antigen of circumstance, E to change rate and HBV-DNA turn shade leads) , still should include long-term curative effect (the 5 ～ after cure the abidance of histology of cleared rate, liver improves virus of 10 years the) such as rate. Current, α interferon by fair the content of bane of first selection disease-resistant that considers as remedial children chronic second liver. Children uses α interferon treatment, specific dosage occupies the child's age, tall short fat poor condition to decide by doctor root, period of treatment is 12 months. Among them the period of treatment of liver of virus mutation chronic second and nephritis of second liver dependency is relatively longer; is additional, the person that accompany inchoate liver cirrhosis should as a child dosage begins therapy. Should notice, 12 months are a primary period of treatment, because the immunity of children is able to bear or endure,suffer condition to be highlighted than growing up, respondent difference, because this period of treatment wants,grow. Ever thought liver of children acute second does not need to use α interferon in the past, but as a result of liver of children acute second turn slow rate is higher, because this expert suggests according to newest progress, acute second liver also needs to use α interferon in remedial later period, break Xiang Man sex to change development with block. Under photograph comparing, the incidence of a disease of third liver is lower than second liver, but progress of children third liver is rapid, cause cirrhosis of the liver, liver cancer more easily than second liver. So, undertake active disease-resistant poison is treated very necessary. The combination of interferon of α of third liver first selection and virus Zun is treated. Acute third liver should use α interferon treatment as early as possible, because it can prevent a patient's condition,development is chronic. Period of treatment of acute third liver is 4 ～ 6 months, period of treatment of chronic third liver is 12 months or above. The period of treatment of virus Zun is 6 ～ 12 months. Answer with medicine the standard is orderly, if remedial program is non-standard, low, recrudesce leads not only efficiency to appear high, easily still harmful response. Treatment of interferon of α of third liver classics is effective person, about 10% may have a relapse again. Recrudescent little patient is passed again associated disease-resistant poison is treated, partial little patient still can be cured. The parent of illness recrudesce little patient need not scared, taking the child to go please the specialized subject sees a doctor, find out a reason in time, adopt relevant measure to continue to treat. (the exercitation edits: Plum apricot)