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Monday 16 July 2007

Second fights ill poisonous whole strategy before liver pregnant

(One) Western medicine of   of poisonous health care of disease-resistant of the Western medicine before pregnant is treated advocate include to restrain virus to duplicate with cleared virus, adjust body immunity function, protective liver cell reachs stimulative liver rejuvenesce, relieve a symptom, relieve inflammation, improve liver function. These are the good foundations that lay to become pregnant and bear healthy darling to hit. 1. Disease-resistant poison treats   to be affected to virus of chronic second liver, virus is duplicate index lasts electropositive and the woman that preparation bears, undertake before pregnant disease-resistant poison is treated, the virus inside cleared body is an important step. Current, effect of disease-resistant bane content is not well-content. What second liver virus can restrain temporarily after application is duplicate, this kind of inhibition after stopping drug disappears, already can be replied to be made the same score to raw water again by low-key index. Some medicaments action is slower, need to just can see the effect more for long. Because disease-resistant is poisonous the curative effect of medicaments is finite, and show effect in the ability when virus is duplicate and active only, reason treats apt of chronic second liver to use drug jointly in recent years, in order to heighten curative effect. (1) . Interferon (Interferons IFN):It is current pair of accepted second liver virus are duplicate the remedy that has certain effect. Its action mechanism is: The first, block is broken virus breeds and duplicate, basically carry disease-resistant poisonous protein (AVP) , bring about MRNA splitting decomposition, those who prevent second liver virus is duplicate. The 2nd. Revulsive the I of liver cell film that suffers infection kind MHC antigen expression, the identifying of stimulative Tc cell and kill and wound effect. Current and clinical basically use gene project interferon, include interferon A-1b, a-2a A-2b. 1) recombines interferon.a-2b(to disturb can, intron A) : Every time 3 million unit, inject inside flesh, daily 1, use consecutively the 1 instead after week is tertian 1, 3-6 of period of treatment month. Antigen of E of second liver virus (HBeAG) and DNA of second liver virus turn shade rate can amount to 30%-70% , restrain second liver virus duplicate result is positive. But antigen of E of virus of liver of great majority second still lasts electropositive, likelihood and conformity of DNA of second liver virus are concerned. 2) . Interferon of A-1 gene project (disturb clever) : Every time 2 million - 6 million unit, inject inside flesh, daily 1, period of treatment 2 months. Antigen of E of virus of liver of near future second turns shade is led 55% . The curative effect of interferon, each report is differ, shade of antigen of E of second liver virus turns rate is average in 40%-50% . To heighten curative effect, interferon of the reoccupy after useful and coriaceous hormone dismantles, but the hepatitis of chronic activity sex that needs to notice the illness is more serious (slow vivid liver) avoid is used, can make an illness exasperate otherwise. It is to admitting by before the person that the second liver virus of C gene mutation is affected, namely antibody of E of second liver virus (fight - HBe) is electropositive, second liver virus - the chronic hepatitis of DNA positive, , use large dose interferon, curative effect is not ideal. B and Y interferon are duplicate to second liver virus curative effect is inferior to A-IFN. Affect the factor of interferon curative effect: It is hepatitis of chronic activity sex (slow vivid liver) excel is chronic defer sex hepatitis () of slow change liver. 2 it is a female relatively male curative effect is good. 3 it is heighten of third ammonia acerbity transaminase person acid of ammonia of third of curative effect excel turns ammonia is normal person. 4 it is antigen of second liver surface, antigen of A of second liver virus, price of effect of DNA of second liver virus is low person curative effect is better. 5 it is curative effect of the person that had not used disease-resistant bane content and immune depressor relatively good with the person that disable too. 6 it is big it is better that dosage is like with the person that grow period of treatment. . Side-effect and size of dosage of accident of period of treatment are concerned. The commonnest be " flu appearance disease group " , expression is Wei cold calorific have a headache systemic ache is lack of power etc. But after continue to apply or reducing an amount, often reduce gradually. Give out heat to cross a gender more common at head agent, did not discover and curative effect and relation. Also can cause leucocyte to reduce plaque etc. After stopping drug, constant proper motion restores, do not affect cure. Think with its it fights virus or couplet of immune adjustment medicine is used more at present, the likelihood heightens curative effect. (2) does not have annulus bird glucoside (Acyclovir ACV, homebred A Pu Luowei) : This medicine is nucleotide analogue, have inhibition to all sorts of DNA virus. It is inside body kinase of classics thymus pyrimidine (the 3 phosphoric acid that TK) activation change fights virus active to have do not have annulus bird glucoside, latter is had control DNA-p and chain of DNA of break down virus outspread action, it is better to be like herpes virus action to having the virus of TK accordingly, second liver virus does not have TK, reason effect is general, think more as operable as interferon curative effect relatively sent. Usage is daily 15 milligram / kilogram weight, drop of the vein after cent fluctuation midday is attenuant is noted, last 2 hours use consecutively 30 days, stop reoccupy 15 days 15 days next, period of treatment is 60 days. Home reports curative effect is differ, the effect is inferior to A- interferon. (3) . A candy adenosine (Ara-A) and adenosine of candy of A of odd phosphoric acid (Ara-AMP) : This is both all be purine analogue, can restrain virus DNAP and nucleotide acid optionally reductive enzymatic active, prevent DNA virus to duplicate. Because side effect of these two kinds of drug is bigger, use less already in recent years. (4) . Get together flesh afterbirth (Poly:C) : For revulsive of artificial complex interferon, domestic application is longer, curative effect fails to affirm all the time. Not remarkable to curative effect of chronic second liver. Usage is 4 milligram, inject inside flesh, every week 3-6 of 2 period of treatment month. (5) . Rummy husband is decided (Lamivdine, glucoside of acting afterbirth of 2 to decoke, 3TC) : For nucleotide kind medicaments, it is the heat that in recent years disease-resistant bane content studies, progress is very rapid. The thymus pyrimidine kinase that nucleotide analogue basically produces through virus and changeover record enzymatic active, contend for sexual mix into to enter the DNA chain of virus unexpectedly with nucleotide acid, stop the extension of DNA catenary and synthesis. Make of virus duplicate to be restrained and produce disease-resistant poisonous effect. Heretofore already had more than 2000 to undertake II period is mixed inside global limits the clinical experiment of III period, among them the oldest series takes medical time the longest it is to be in our country mainland (429) with Hong Kong, taiwan Singapore (358) . Take medicine to amount to 2 years above. Hong Kong and other places considered to make liver vivid check to treating from beginning to end. As a whole, daily take rummy husband to decide 100 milligram, at 2-4 Zhou Shi level of DNA of virus of serum second liver is distinct drop, shade of accumulative total of DNA of virus of liver of the 12 second when week turns rate amount to 90% above, 52 shade of DNA of second liver virus lasts to turn when week rate for 80% , antigen of E of second liver virus (antibody of.e of virus of HBeAG)/ second liver (fight - rate of HBe) serum changeover is 5%-8% . In the 42nd liver when week vivid check checks, harmony of hepatic and necrotic inflammation is improved apparently. The evolution that liver fiber influences also is compared comfort group for little. After patient of chronic second liver applies rummy husband to decide long-term remedy, second liver virus chooses action, the mutation of occurrence virus, I YMDD mutation is heavy common, II YMDD mutation is scarcer. The undesirable melon that rummy husband decides is general lighter, also did not produce apparent skeleton to restrain with serum pancreatin, the phenomenon of flesh enzymatic heighten. Individual patient sees illness aggravation at stopping medical hind, liver function is wrong. Heretofore has a few stories that at stopping drug hind of a few months dies. Still cannot have immediate concern with Xiang certainly. (6) . Poison of disease-resistant of virus sex hepatitis treats the problem of existence, : " arrest wishs nest vertebra looks in all " ? of bureau acute communicable diseases exists at present curative effect is not quite satisfactory recrudescent rate is high, some medicaments noxiousness are bigger with medical portion costly wait for a problem. In the meantime, second liver virus reachs effective consistency not easily inside the cell, because this affects the result of disease-resistant poison. In the meantime, liver virus divides second to duplicate in liver cell outside, still be like bile duct in other organization, pancreatic and lymphatic in waiting for a cell, duplicate. . Disease-resistant bane content keeps clear of more easily the hepatitis virus in blood, and the hepatitis virus in organizing a cell is kept clear of not easily, make main reason of recrudesce. In addition, second liver virus is easy produce mutation, mutation virus often happens to disease-resistant bane be able to bear or endure medicine or curative effect are bad, if individual plant of mutation of area of the C before second liver virus is affected, interferon treats the effect to differ. Easy form of chronic second liver is able to bear or endure into human body immunity suffer, bring about disease-resistant bane content to treat the effect not beautiful. So, cure of virus second liver still needs to pay attention to pair of disease to support treatment, medicine of Chinese and Western is treated especially integratedly. The person that second liver virus is carried (the cure of ASC) basically is treated with Chinese traditional medicine of doctor of traditional Chinese medicine give priority to. 2. Adjust airframe immunity force. The application of immune conditioning agent is fighting virus immunity force at rising. Poisonous to disease-resistant undertaking only before pregnant of the person that second liver virus is carried cure is insufficient still, because at present Xiang of second liver virus is like interferon and nucleotide kind medicaments, can restrain second liver virus to duplicate only, and cannot keep clear of thoroughly inside human body second liver virus. Immune conditioning agent can improve the immune function of human body, be opposite especially the distinctive immunity of second liver virus, can identify and destroy infection of second liver virus and target cell, virus of cleared second liver. The immune conditioning agent that is used at treating chronic second liver at present has agent of Tu Bu of Zun of Mi of Zunxuan of element of thymus peptide thymus, immune ribonucleic acid, particularity of second liver virus transfers factor and Chinese traditional medicine of doctor of traditional Chinese medicine to wait. At present the cure of immune conditioning agent still is put in the problem that a few need solve, if the adjustment of system of human body immunity and function present network appearance, daedal, and the immunity of liver of virus sex second adjusts and immunity is able to bear or endure get a mechanism, have not clarify completely up to now; immunity detects the method still is not perfected, the immune condition that still cannot reflect human body to be cut truly and functional; use immune conditioning agent to still cannot undertake according to condition of human body immunity specific aim is treated. In addition, immune conditioning agent is right the treat mechanism of chronic second liver, adjust inside human body especially immune mechanism, not clear still. Accordingly, immune conditioning agent applies in valve of chronic second liver, still lack specific aim. Curative effect is not quite satisfactory still. Still remain to study further. Think at present, use the immune conditioning agent that has particularity immunity function in the light of second liver virus only, the virus of cleared second liver with more effective ability, the S2 before the S of virus of the liver that be like second is mixed treats sexual vaccine, CTL polypeptide is vaccinal, DNA vaccine. But still be in at present experiment and clinical research phase. (1) . Thymus peptide: Pass the active that affect CAMP and enhances T cell. Usage is daily 10-20 milligram. The inject inside flesh or vein drop are noted. 2-3 of period of treatment month. (2) . 2(IL-2) of leucocyte interpose element: Hyperplasia of cell of effect of can exciting immunity and lure unripe Y- interferon. Usage is daily 1000-2000 unit. Inject inside flesh. Daily 1. Day of 28-56 of period of treatment. Antigen of E of virus of liver of partial patient second turns shade. (3) . Sex of lymphatic factor activation kills and wound a cell () of abbreviation LAK cell: The department uses lymphatic factor (get like IL-2 and cell of the body before Y-IFN) stimulates his. Domestic report can make antigen of E of virus of liver of partial patient second and DNA of second liver virus turn shade. 3. Protect liver cell medicaments. (1) . Beneficial liver is clever: By the corpus luteum that milk thistle careless seed extracts, can stabilize liver cell film. Another of stimulative liver cell. Usage is every time 2 daily 3, period of treatment 3 months. (2) . Puissant peace. : From the Gan Tian element that extracts in glucoside grass, liver of toxic to 4 chloridize carbon sex is damaged effective, to hepatitis cure, in order to fall enzymatic function is better. There is bounce after stopping drug. Have liquid of inject of glad of benefit of congener product pleasant, fall via research enzymatic effect excel is puissant peaceful. The usage of fluid of inject of pleasant benefit glad joins 10% dextrose for 150 milligram fluid vein drop is noted, daily 1. 1-2 of period of treatment month. Notice pair of heart kidney functions sad unexpectedly, serious disease of natrium of tall blood of low blood Potassium is banned with, pregnant woman and infant are unfavorable with. (3) . Qi Dunguo is acerbity piece: Usage is 80 milligram, daily take 3 times, period of treatment is 3 months. Couplet benzene compares ester, usage is 15-25 milligram, daily take 3 times. Third decreases a quantity to compare ester after ammoniac acerbity transaminase is normal, usage is 15-25 milligram, daily take 3 times, third decreases a quantity to maintain after ammoniac acerbity transaminase is normal, period of treatment 6 months. All have fall enzymatic action. (2) .   of   of poisonous health care of disease-resistant of the traditional Chinese medical science before pregnant 1. In   of officinal disease-resistant poisonous   (the officinal family in 1) is custodial. 1) . Reservior quantity is unfavorable and too much, in domestic provide for oneself officinal and unfavorable too much. It is advisable to maintain 3 months to use dosage. 2) . Notice operating period: The idea of period of efficacy of the operating period of medicines and chemical reagents and medicines and chemical reagents is different. The operating period of medicines and chemical reagents is to show store is regular after time, quality produces the term of service that place of medicines and chemical reagents provides, expire examination qualification still can continue to use. In officinal and custodial appropriate, operating period can be lengthened appropriately commonly. The period of efficacy of medicines and chemical reagents is to show medicines and chemical reagents is below reserve requirement of the regulation, can carry the term of quality. 3) . Notice outer packing checks: When buying drug, observation packs a box (bag) have without damaged, the specification of the outer packing inside water be soiled is consistent, inner packing heal is close. 4) . Appropriate deposits: The position that the family uses medicine to should be put in to secure (inside medicine chest of glass case drawer) , avoid sunlight point-blank, high temperature, damp. If the family used medicine to change to pack bottle, must add drug label, keep clear drug name, norms, dosage. To the name, dosage has interrogative drug, do not use, lest appear accident, prevent children to be fed by accident. 5) . Prevent degenerative pollution: Agent of syrup of fluid of profess to convinced, after mixture opens bottle, want to give out in time, not gone should put in shady and cool place to deposit (best freezer saves) , lest become moldy, ferment degenerative. Take medicine to should use to how many, bottled medicine fluid can teem, unfavorable will much surplus answers bottle inside, more unfavorable take drug directly in opening with the mouth, lest medicines and chemical reagents is polluted, degenerative. If medicines and chemical reagents appears,become angry bleb changes flavour, cannot take again. 2. The officinal method in the choice. 1) . Be in next the doctor is directive choosing: Although opposite Western medicine, the poisonous side-effect of Chinese traditional medicine wants low much, have a lot of Chinese traditional medicine even among them itself is commonly used food, but because Chinese traditional medicine has respective sexual taste,put in the characteristic such as classics 's charge. So Chinese traditional medicine has its respective comfortable be recruited. Prepare the woman that conception bears especially. , should be more with medicine before pregnant below the doctor's guidance science uses drug, cannot take drug blindly. For example, belong to the patient of kidney empty likewise, some kidney deficiency of yang cause, have a plenty of kidney deficiency of yin with irritability to cause, clinical to both remedial method polarity, if use wrong drug carelessly not only at disease profitless, can accentuate instead illness. Accordingly, officinal in choose previously, going consulting a doctor is very necessary. 2) . Read manual of medicines and chemical reagents carefully, : Usually manual of medicines and chemical reagents can carry the knowledge that gets used to disease to notice to wait for outline sex with medicine for the effect that gives a patient this drug, special crowd needs to notice especially, be like pregnant woman. 3) . Adj choose drug: Should differ by clinical traditional Chinese medical science of the patient disease go choosing to use drug. Like diseases with such symptoms as coastal pain not the patient that the patient of easy selects damp and hot of courage of; of bolus of liver of easy of the root of Chinese thorowax chooses mixture of mattress lotus clear liver to wait. 4) chooses drug integratedly: Namely the disease of integrated patient, card symptom undertakes analytic will choose medicationing. Two above medicaments is chosen to have treatment below groovy circumstance, adjust at any time as the progress of the disease, change with medicine. (the exercitation edits: Plum apricot)

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