You drop disease-resistant poison " a bottomless pit " ?

What advantages and disadvantages does the disease-resistant bane content with commonly used liver have each? Current, second liver basically cannot be cured thoroughly, remedial target has two, make sure liver function runs to; is deferred or prevent hepatic pathology sex to worsen normally namely (namely the pathological changes) such as liver cirrhosis, liver cancer. Want to achieve two afore-mentioned goals, with respect to need block breaks liver cell inflammation and happen necrotic, and second liver virus is cause liver cell inflammation and produce necrotic prime cause, this shows, disease-resistant poison is the most important, the basiccest measure. Be fought by the expert's accepted second liver at present virus medicaments altogether two kinds big, in all 5 kinds, it is interferon respectively kind (common interferon, lasting effect interferon) with nucleotide kind (rummy husband is decided, Adefuwei, favour replaces Ka Wei) . So, what advantages and disadvantages do 5 kinds of medicaments have each? 1. Interferon: Curative effect and trouble are in together " wealthy person medicine " the 　 somebody occurrence interferon praise the first milepost of content of bane of disease-resistant of the liver that it is second, from last centuries 80 time end rises at the beginning of 90 time, interferon applies extensively at second liver cure, also indicating the history is advanced " interferon times " . The interferon that just goes out brings people not little surprise, show unprecedented curative effect. Through the patient of chronic second liver that interferon treats normally, about 35% above can be achieved book curative effect, if use thymus peptide is combined again on the foundation here, curative effect is returned but further upward. Interferon is a kind of inject uses 2 drug, medicaments half-life is short, want to maintain medical effect to must lie between day of inject, this brings not small anguish and inconvenience to the patient. 2005, the lasting effect interferon of company of collect family name sends Luo Xin to be approved through American FDA, be used formally at second liver cure, make this problem gets fixed rate alleviate, because it needs weekly injection only. Doctors discover, the transaminase before cure is tall (but under normal value 10 times) , DNA index is less than 2 × 108 person and what effect of therapy of female patient use interferon comparatives is good, in addition, fiber of transmission of the weak point of course of diseases, baby that be not a mother, liver changes rate light and the person that affect without virus of amalgamative and other hepatitis uses the effect also perfectly. Additional, disclose according to Professor Gao Zhiliang, interferon still has an extraordinary ability, it can make the antigen of second liver surface of one part person turns unexpectedly shade, this amount is not large nevertheless, have 3% only, and this is rummy husband waits for nucleotide surely kind medicaments place cannot accomplish. "Time reveals a person's heart, time reveals a person's heart " , as interferon dosage increase ceaselessly, and lengthen of period of treatment ceaselessly, the defect of interferon appears more and more clearly before people. Using the beginning of interferon a few days, doctors discover a lot of patients resembled weighing a cold general: Calorific, have a headache, muscle of lack of power, whole body and articulatory ache... nevertheless, this kind of symptom can disappear after injecting 35 times. Some patients are gone after interferon, discover trichomadesis begins increase, take a comb to comb sometimes, hair one continuously is dropped downward. The marrow of the very much person that use is restrained, plaque and leucocyte can be reduced, the patient feels very afflictive. Little part patient may appear the harm of mental respect, like depressed, covet disease, heavy spend angst. Nevertheless, these harmful response are only appear on partial patient body, and its are injured cross a gender, hind of out of service arrives a few days a few months, afore-mentioned harmful response can vanish completely. So, in the process that use drug, patient need is close and advertent the occurrence of these harmful response, unusual situation tells a doctor immediately, such doctors can be adjusted according to the degree of harmful response dosage and frequency giving drug. Liver function breaks acting countervail (the 10 times above that transaminase prep above is worth normally) the patient wants special caution, because once they used interferon, liver function will produce quick harm, appear serious and icteric. Professor Gao Zhiliang emphasizes particularly, use interferon person should monitor deputy reaction closely, want every 3 months to detect 1 times the index such as thyroid function, blood sugar and uric convention. If Jia Kang already existed before cure, had better have controlled with medicaments first, resumptive interferon is treated. Additional, answer to evaluate psychosis regularly, especially apparently depressed to appearing disease and the patient that have suicidal tendency, should stop drug instantly and guard closely. Harmful response is more, it is the one big bottleneck that limitative interferon uses extensively. The price is high, it is the another big drawback of interferon. 70 money control common interferon, lie between a day to hit, a month comes down to go with respect to bad news more than 1000 money. Lasting effect interferon is expensive more breathtaking, price is in 1000 ～ 1400 yuan between, a such months come down to also want many 5000, the advantage is a week is hit went, effect excel is common interferon. The period of treatment of interferon at least half an year, this half an year comes down common interferon wants 669 yuan about, lasting effect interferon wants about thirty thousand and five. This still is the money that disease-resistant poison spends merely, calculate on protect liver to fall the other remedy such as enzymatic medicine, still have a series of examination charge, the patient that this is not an average income is OK easily susceptive. What is more,the rather that, some patients period of treatment returns more than half an year. 2. Rummy is infinite good, be close dusk only? The second liver that is approbated generally by the whole world fights virus medicaments, besides interferon, still another gate is sent -- nucleotide kind medicaments, this kind of medicaments in last centuries the later period in 90 time begins to be used extensively at treating second liver. The old the son of one's master of this one school is illustrious and famous rummy husband is decided (trade name " He Puding " ) . Rummy husband is known as poison of second liver disease-resistant surely the medicaments of the 2nd milepost sex. In those days, the scene when rummy husband just went surely is infinite, voice is very loud, the media at that time still perhaps can recall to give rummy husband to decide what kind of evaluation dimly in the memory in wardmate of liver of a lot of second -- " (rummy husband is decided) came out to bring hope and good news for patient of countless second liver " . Rummy husband enters liver surely pass inside the cell what in controlling HBV process, need is enzymatic -- HBV polymerization is enzymatic, the synthesis that prevents virus effectively and duplicate, the patient of manhood of slow second liver that applies to HBV activity sex to duplicate () of 16 years old of above. Rummy husband has effect surely very fast, a lot of patients use drug about 1 week hind hind show curative effect, HBV-DNA average shade turns time shifts to an earlier date than interferon cure 2 months. Rummy husband decides the 2nd merit is HBV-DNA drops range is big, shade turns rate is high, the head 2~3 that using month, DNA can drop commonly 2~3 logarithm class, be like from 107 drop 105~104, use left and right sides of half an year to have the person DNA that exceeds an in part can shade turns. Rummy husband decides the 3rd merit is accommodation wide, because its are poisonous side effect is small, the case of illness that danger of a few illnesses weighs unfavorable use interferon can achieve better curative effect after use rummy husband is decided, add rummy husband to need only surely everyday profess to convinced, relatively interferon goes to the lavatory greatly. However, rummy husband is good very surely, but use long make second liver virus arises easily " aesthetic exhaustion " , below the eyelid that can decide in rummy husband unexpectedly, inexorable thrive. Be what lets virus be fear of rummy husband to decide no longer? Scientists discover after anatomize, the gene of original virus already appeared mutation, decide to rummy husband already no longer " cold " . As the extension of the time that use drug, the patient produces the scale heighten that virus mutates, it is the first year 14% , use rummy husband to decide that is to say full in patient of a year, the husband of person reoccupy rummy that has 14% decides already invalid; the 2nd year this number turns into 38%; turns into the 3rd year 49%; turns into the 4th year 66% . Tall mutation rate restricted the long-term application that rummy husband decides. Some patients are able to bear or endure in hair unripe virus occurrence illness of the meeting after medicine mutates is aggravating, minority produces liver function to break acting countervail even. 3. Adefuwei: Rummy is able to bear or endure the virus that the husband of rummy of new hope 　 after medicine decides is able to bear or endure medical mutation problem makes doctor and sick people special headache all the time. Rummy husband is able to bear or endure surely how should do after medicine, people is pressing the remedy that expects the move is new appears, adefuwei (have two kinds of products, include homebred " Dai Ding " with the entrance " He Wei force " ) appearing on the market is a timely rain undoubtedly, let be able to bear or endure surely to rummy husband virus individual plant of medicine lowers his head afresh. Actually, adefuwei is fighting virus ability side and do not decide than rummy husband strong, can say to lose even at latter. This body fights virus speed to be decided without rummy husband in its now fast, time having effect is slow, and the intensity of disease-resistant poison is not quite high. The ability after Adefuwei uses 3 months commonly has effect, be in rarely 1~2 lunar DNA can shade turns. So Wei Yi of A heart blessing spends medicaments of the second line that be labelled, be able to bear or endure surely in rummy husband only reserve of the ability when medicine comes on stage. However, experts think, adefuwei can serve as medicaments of a gleam of to use likewise, just the patient needs to have longer patience, await the occurrence of curative effect. Adefuwei can arise likewise be able to bear or endure medicine, but occurrence opportunity is decided than rummy husband smaller, appear be able to bear or endure the time that medical virus mutates is a few later also. As a result of " Dai Ding " and " He Wei force " was 2005 just just appear on the market in home, most patient still resents one year with medicine, so about Adefuwei be able to bear or endure medical problem, homebred still lack relevant data. Congratulate dimension force is used in abroad earlier, the research data of referenced abroad, data of occurence rate of Wei Naiyao of A heart blessing is the 1st, 2, it is 3 years respectively 0% , 1.6% , 3.1% . Adefuwei returns a defect, may cause kidney function namely damage. When clinical trial is being done before Adefuwei appears on the market, the norms that once 4 kinds differ and dosage are used on different sick person, the patient with some bigger dosage (30mg/ day) in function of partial occurrence kidney is damaged. For this, doctors reduce the dose that uses everyday 10mg now, this dosage is considered as to compare safety. Nevertheless, to applying the person that Adefuwei is treated for a long time, ought to monitor kidney function regularly in treating a process. In drugstore along with in seeking a course, the reporter arrives alertly, the medicine that decides in rummy husband has characters of such sex of a caution in the box: "Follow the doctor's advice to be mixed with medicine please stop drug. " a such words, distinguish somewhat with the specification of general medicines and chemical reagents: General medicines and chemical reagents emphasized only " follow the doctor's advice please with medicine " , and rummy husband is decided, emphasized particularly " stop medicine to also need to follow the doctor's advice " . Rummy husband is surely in use process, did not stop medicine to point to to drug cannot stop casually before asking for, it is easy to stop drug otherwise bounce, weight degree is differ. Some person bounce symptoms are lighter, just behave the transaminase to cross a gender to lift. But the person bounce symptom that has about 8% is more serious, appear icteric break acting countervail with liver function, rummy husband invites the issue that give and lawsuit in recent years surely basically is to go out to go up in these patient bodies. Professor Gao Zhiliang also points out, because sex of patient comply with is poorer, often eat eat stop, stop stop eat, this also is to quicken rummy husband to be able to bear or endure surely a of medicine main reason. Decide besides rummy husband, adefuwei, favour also wants to follow the doctor's advice for card dimension stop drug.