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Saturday 21 July 2007

Second liver treats the part that is different from third liver

◆ is bit more identical: 1. Remedial goal is consistent. Treating second liver and third liver is to utmost ground is restrained for a long time or eliminate the hepatitis virus inside patient system, reduce the rate that the necrotic fiber that reach liver changes inflammation of its liver cell, defer and prevent the progress of the disease, decrease and prevent patient occurrence liver function to break the happening of the complication such as cirrhosis of acting countervail, liver, liver cancer, improve life quality of the patient thereby, lengthen its to survive time. 2. Main curative thing is interferon together, especially common α interferon and lasting effect interferon (get together second alcoholize interferon, PEG-IFN α ) . 3. Remedial effect gets likewise the virus gene cent influence with etc element. The remedial effect of second liver and third liver all suffers the effect of a variety of elements, following element is helpful for second liver or third liver patient obtains endurance after cure respondent: Gene of virus of ① third liver is 2 model or 3 model third liver patient (gene of third liver virus is 1 model patient criterion curative effect is poorer) ; Gene of second liver virus is A model second liver patient (gene of second liver virus is C model patient criterion curative effect is poorer) . ② second liver or level of third liver virus are less than 2 × the patient of milliliter of 10 copies / (if the virus inside patient system holds an amount,achieve better curative effect very hard too high) . ③ age is less than patient of 40 years old. ④ female patient. ⑤ affects the patient with virus shorter time. ⑥ hepatic fiber turns the patient with small degree. The patient with better to comply with sex of cure ⑦ . The patient of moderate of ⑧ bodily form. The patient that not amalgamative and other virus affects ⑨ . ⑩ not excessive drinking not the patient of drug taking. 4. The patient of cirrhosis of amalgamative and inchoate liver needs to undertake disease-resistant poison is treated. Although second liver or third liver patient are amalgamative and inchoate liver is sclerotic (acting countervail period liver is sclerotic) hind, can reduce the effect that disease-resistant poison treats, but stabilize to make the virus inside its body maintains, defer or prevent its to produce the complication such as liver exhaustion and liver cancer, the patient still answers to observe next undertaking that disease-resistant poison is treated in the doctor's rigor. 5. All can learn with inchoate virus respondent as undertake disease-resistant poison is treated and forecast its the basis of long-dated and lasting effect. Second liver or third liver patient are treating 12 week hind, if the DNA of second liver virus inside its body or classics of RNA of third liver virus are qualitative,detect show negative, or classics ration detects reduced 2 logarithm level (be equivalent to milliliter of 100 copies / ) above, adumbrative this patient can obtain pretty good curative effect through cure, otherwise Lv of patient take an examination changes remedial program. 6. In cure around needs to be monitored regularly. Second liver and third liver patient should check convention of function of liver function, kidney, blood, thyroid function, blood sugar and uric convention before cure. Liver of the second inside the first month after cure begins and third liver patient can check hematic convention every week, begin to come from the 2nd month inside half an year, but every month checks hematic convention, next but every 3 months check hematic convention. During cure second liver and third liver patient answer every month checks liver function, every two months answer to check liver function inside 6 months after treating an end. Should detect when treating 3 months the virus index of second liver or third liver, should detect again inside 6 months after the end is being reached when cure ends virus index. 7. Emphasize a patient particularly the comply with sex to cure. It is a of effect of treatment of influence second liver and third liver patient main factor to comply with sex of cure. The doctor should begin therapy in the patient forward the natural course of diseases that its explain second liver or third liver in detail, show the necessity that has fighting virus remedial, period of treatment, curative effect and need fee to wait. The harmful response that still should introduce its place to use remedy in detail to the patient at the same time, precaution and the method that reduce medicaments to produce undesirable reaction, and the importance that comes to a hospital check regularly, great care, comfort and urge a patient, with obtaining a patient cooperate actively, heighten the patient's curative effect. ◆ differentia: 1. Common α interferon and lasting effect interferon are first selection of remedial third liver with necessary medicines, but the medicaments that treats second liver besides all sorts of interferon, still have nucleotide kind disease-resistant bane content. 2. Third liver patient had better want to cooperate to use Libaweilin when having treatment with interferon. Rise lasting effect interferon and Libaweilin jointly application is to be aimed at third liver to undertake disease-resistant poison treats the most effective method at present. Comparing effective method next is a common α interferon and Libaweilin rise jointly use. Method of these two kinds of treatment all the method that excel sheet treats third liver with common α interferon. But when second liver patient is using interferon to have treatment, cannot rise jointly with Libaweilin absolutely use. 3. Second liver patient can cooperate to use immunity to enhance medicine when use interferon has treatment (call immune adjustment medicine again) , be like thymus element α - 1, thymus 5 peptide, but third liver patient cannot use this kind of remedy however when cure. 4. Third liver patient should check RNA of virus of its third liver to show masculine gender via assay only, no matter whether its liver function is normal,answer actively undertakes disease-resistant poison is treated. The level of transaminase of third of the cereal inside its body is not to forecast third liver patient to whether appear to interferon cure respondent main index. The third liver patient with treat cereal third transaminase normal jointly with lasting effect interferon and Libaweilin, its virus learns respondent rate and the likeness of effect of third liver patient that use this medicine to treat cereal third transaminase to lift. Accordingly, cereal third transaminase spends elevatory third liver patient normal or gently, want the RNA of third liver virus inside its body to show masculine gender only, can undertake disease-resistant poison is treated. But the second liver patient with liver regular meritorious service, although the DNA of second liver virus inside its body shows masculine gender, can not undertake disease-resistant poison is treated temporarily however. Because,this is, right now second liver patient is in immune palsy more, undertaking to its disease-resistant poison is treated is to be obtained hard effective and respondent. Second liver patient is in only liver function is unusual (cereal third transaminase is elevatory) when just can consider to undertake disease-resistant poison is treated. 5. Patient of acute second liver is not must undertake disease-resistant poison is treated, but patient of acute third liver must undertake disease-resistant poison is treated in time. Because,this is, acute second liver is one kind is restricted oneself relatively sexual disease, few change becomes chronic hepatitis. Patient of liver of most acute second should notice to rest only, the possibility that undertakes cure has recovery protecting liver appropriately. And metropolis change is the patient of acute third liver of above of about 50 % chronic hepatitis, to acute third liver so the patient must undertake disease-resistant poison is treated in time. Use interferon can reduce change of acute third liver to become the odds of chronic third liver significantly, accordingly, once the patient is confirmed RNA of virus of its third liver shows masculine gender, answer to undertake disease-resistant poison is treated instantly. 6. The third liver patient of cirrhosis of amalgamative and terminal liver still does not have right disease-resistant bane thing to be able to be chosen at present. Because this kind of patient is able to bear or endure hard more,get the harmful response that produces after use α interferon, conditional person should implement hepatic transplanting method. And the second liver patient of cirrhosis of amalgamative and terminal liver can choose rummy husband to wait for nucleotide surely kind disease-resistant bane content has treatment. 7. The accident that third liver patient has disease-resistant poison treats time basically depends on the gene type of virus of liver of the third inside its body. If its gene type is 1 model, the remedial time that the patient needs one year commonly; If its gene type is 2 or 3 model, the patient needs the remedial time of half an year. And the accident that second liver patient has disease-resistant poison treats time depends on the circumstance of antigen of E of liver of the second inside its body. If antigen of second liver E shows negative (second liver " small 3 this world " ) , hint area of the C before virus of its second liver produced mutation, right now the patient needs to extend the time that disease-resistant poison treats, for example, the time that use interferon treats can be lengthened to a year of above. If antigen of second liver E shows masculine gender (second liver " big 3 this world " ) , can shorten relatively the time that disease-resistant poison treats, for example, the time that use interferon treats can shorten for half an year. (responsibility edits: King sea E)

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