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Friday 15 June 2007

Cope with second liver to be able to bear or endure I have drug 3 action

China is liver of the second on the world and patient of cancer of the liver's most country, take the whole world about 1/4. On April 21, the countrywide second liver that precaution of disease of Ministry of Public Health controlled Hao Yang of bureau deputy director general to announce Ministry of Public Health to was begun 2006 epidemiology findings, this investigation and last time apart more than 10 years, relevant data shows, antigen of surface of liver of second of 59 years old of crowds carries 1 ~ of countrywide rate for 7.18% , the person that and our country still has antigen of second liver surface at present carry makes an appointment with 93 million person, patient age is in mostly 20 to 50 years old between, situation of prevention and cure of second liver virus still austere. Each country " guideline of second liver prevention and cure " all point out clearly, the overall objective that chronic hepatitis B treats is: Utmost ground is restrained for a long time or eliminate second liver virus. However, be able to bear or endure the stumbling block on the way that medicine makes implementation of patient of slow second liver treat overall objective however, also become the bottleneck that poison of second liver disease-resistant treats at the same time. Teach the introduction according to Zhuang Hui of academician of Chinese Academy of Engineering, chronic second liver is disease of long-term progress sex, need long-term treatment, if undertake nucleotide kind the disease-resistant poison of medicaments is treated, the time that the patient needs 2 years at least, and in fact, the patient of 88% needs longer time. Long-term remedy certainly will increases disease-resistant bane content to be able to bear or endure medical risk. Be able to bear or endure once medicine happens, can lose curative effect or curative effect to be reduced greatly to the remedy with effective virus originally, cause patient virus to rebound then, disease progress; at the same time, be able to bear or endure after medical happening change medicine to perhaps add medical treatment, increase a patient to produce much medicine to be able to bear or endure medical risk, limitative follow-up treats the choice of plan, the patient also will bear heavy psychological burden and mental pressure, serious negative sentiment is met even nearly one pace brings about illness accentuation; in addition, be able to bear or endure the remedial expenses that medicine causes rises, also reach aggravating patient the economic burden of its family. Center of sanitation of spirit of hospital of famous psychology expert, Mount Hua applies Shen Xun to teach the introduction, the recrudesce of disease of concern of second liver patient of more than 60% above, infect family, and the disease is long treat do not heal and bring heavy domestic burden, and be able to bear or endure the culprit that medicine causes these concern and all fear just about. Do not need doubt, be able to bear or endure medicine had caused second liver patient badly to be in gradually the disease, psychology, ternary burden that goes up with the life. The authoritative expert of domain of prevention and cure of second liver virus a few days ago at this point problem, gave out virus is able to bear or endure medical mutation prevents a respect 3 old strategy: 1. Logical choice nucleotide (acerbity) analogue fights what virus treats to get used to disease. 2. Poisonous to having disease-resistant cure gets used to the patient of disease, if choose nucleotide (acerbity) analogue, be in as far as possible initiative disease-resistant poisonous action is chosen when treating strong, be able to bear or endure the medicaments with medical mutation low occurence rate. Newest the clinical data that publish showed continuously favour for Ka Wei lowest is able to bear or endure medical occurence rate and abiding the capacity that controls virus. Use favour replaces the patient of chronic second liver that treats at the beginning of nucleotide block Wei 5 years, the patient virus of 93% carries a quantity to fall to cannot measure a level (Lt;300 is copied / milliliter) , 5 years accumulative total is able to bear or endure medical occurence rate is only 1.2% . The newest and clinical data that will publish on European liver ill annual meeting on April 26 this year shows: Use favour replaces the patient of chronic second liver that treats at the beginning of nucleotide Ka Wei 96 weeks, the patient virus of 79% carries a quantity to fall to cannot measure a level, compare with the photograph before cure, the patient's virus carries a quantity to drop on average extent amounts to 7.82 Log10 to copy / milliliter; and Adefuwei contrasts group only the patient virus of 50% carries a quantity to fall to cannot measure a level, and the patient's virus carries a quantity to drop on average extent is copied for 5.96 Log10 only / milliliter. Each nucleotide kind medicaments 48 weeks fall virus data also is shown favour for Ka Wei of fast, powerful effect control virus capacity. 3. Raise sex of patient comply with: Using nucleotide (acerbity) during analogue undertakes disease-resistant poison is treated, should follow the doctor's advice on time, full amount takes drug, restrain virus as far as possible in lowermost level, do not give virus the chance of stage a come back. In addition, still should detect regularly during cure, every 3 months detect HBV DNA level. Occupy story of World Health Organization additionally, the whole world makes an appointment with 2 billion person to ever had contracted hepatitis B virus, among them the person that 400 million person is chronic infection, as the development of the disease, cirrhosis of the liver exhaustion that every year about more than 1 million person affects be caused by at hepatitis B virus to death, liver and cancer of cell of the former liver that send a gender. This year on May 19, world hepatitis is allied together the orgnaization such as World Health Organization, Red Cross, Gaicijijinhui, the world hepatitis day that starts by a definite date formally 5 years in the whole world moves, aim to cause the comprehensive attention that the public prevents and cure to second liver, in home, world hepatitis is allied also will hand in hand foundation of Chinese hepatitis prevention and cure develops relevant promotion activity. (the exercitation edits: Plum apricot)

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