The liver that fight second is exquisite " individual change "

Nbsp; develops as what second liver treats, demand of immunity of oneself of medicaments, host, patient 3 person be united in wedlock apply processing to read aloud to be place of medical affairs bound to be agreed with extensively. Want virus of liver of thoroughly cleared second to not allow really easy, but clinical practice tells us, want ceaseless exploration only, chronic second liver is not a disease that does not have any hope conquer. From December 2005 " guideline of prevention and cure of Chinese chronic hepatitis B " (next abbreviation " guideline " ) roll out formally up to now, the ideal development popular feeling that disease-resistant poison treats, normal disease-resistant poison treated medicaments to also receive wider application, in this process, fight virus cure to make a lot of patients are benefited from which, what the cure of interferon makes patient of liver of a lot of second realized an illness is long-term alleviate, even some of patient appeared the ceaseless emerge in large numbers of the drug of nucleotide acerbity analogue with new; of changeover of exterior antigen serum lets do not have interferon to get used to disease more very much or the disease makes progress the patient of liver cirrhosis is OK also will control organic meeting to accept treatment through medicaments, but as use crowd increase, also exposed disease-resistant poison to treat a lot of medium problems, the problem of period of treatment that for instance interferon treats, for instance nucleotide analogue is able to bear or endure medical problem is waited a moment. For this, we interviewed Sichuan center of catch a disease of feeling of courtyard of university China Western medicine Professor Zhao Liansan. Professor Zhao has feeling greatly to this " every patient hopes to obtain exterior antigen to change, this give no cause for more criticism. Really, the disease-resistant poison cure that at present clinical practice proves to be based on immune adjusting control can help a few patients achieve this kind of curative effect, but this scale is lower. The remedial target; with reasonable set strengthens doctors and patients to communicate, use what suit most is individual change remedial plan, it is the key of conquer disease. " 　 cure target wants rationalize 　 generally speaking, clinical cure divides second liver basically for target of 3 phase sex. The first phase: Second liver virus is duplicate get inhibition, liver function returns to normal; 　 the 2nd phase: E antigen turns shade, occurrence E antibody, namely changeover of E antigen serum, liver function ALT is normal, second liver virus is duplicate get persistent inhibition. Clinical go up, the patient that serum of occurrence E antigen changes, oneself immunity is brought into play to have an accuse and denounce at a meeting with virus, virus is duplicate the inhibition that gets persistent, the disease after stopping drug alleviates continuously. Clinical trial proves international, interferon cure obtains changeover of E antigen serum to be able to help a patient lower the rate that liver cirrhosis and liver cancer produce greatly. The 3rd phase: In obtain E antigen on the foundation of serological changeover, conditional patient continues to treat, hopeful obtain exterior antigen to turn shade, exterior antibody turns in relief, namely changeover of serum of antigen of second liver surface. The expert calls this kind of position clinical cure. Whether be stated so, academia is being discussed. But undeniable is it it is clinical really go up to approach cured state most. " guideline " point out clearly, positive of antibody of second liver surface expresses to have immune power to second liver virus, see the person that at hepatitis B rehabilitation reachs vaccine of vaccinal hepatitis B. This is in chronic second liver has very important sense in expatiatory course of diseases. current medicine level, still only very small proportional patient can reach the 3rd level (here the domain has what large and clinical data proves international exclusively to get together glycol changes interferon A-2a, the scale that is aimed at all patients also has 3-5%) only, although proportion is very small, but it is to let us see second liver after all " cure " hope, the scholar also is in the expert of each country to how increase this one proportion having indefatigable effort. To 2 class target, it is the actualest, also be a mainer goal, domestic and international clinical research has confirmed, serological changeover achieves implementation E antigen not only the abidance of the illness alleviates, stop medical hind to relapse not easily, and the implementation of this one target also is to obtain antigen of higher end surface the precondition of serological changeover. Those who treat an opportunity is individual liver of the second that change 　 arrives from infection coming on is a lengthy process, in this process, between airframe immunity and virus relatively strength is very fundamental, master only chased after first-rate to treat an opportunity, chose accurate interpose method in time, remedial effect ability gets most change greatly. Home, patient of major second liver is through mother baby transmission infection, in infant period, because airframe immunity is diseased, cannot identify second liver virus, caused immunity to be able to bear or endure suffer, but as immune system gradually perfect, immune system begins to spread out immunity to virus cleared action, form seesaw battle. If give the disease-resistant that is based on immune adjusting control in time poison,treat at this moment, often can obtain the result of favorable treatment. Although remedial opportunity is not fixed,be in a certain age, patient of black prime of life, to the cure of immune adjusting control reaction has been compared commonly. Clinical go up the most commonly used judgement index is transaminase, if transaminase is elevatory, it is normal to be in 2 times arrive 5 times between, this may be the remedial opportunity with chronic second better liver. The individual situation of the individual patient changing 　 that treats plan is different, treating plan nature also is somewhat of difference. Accepting remedial initial stage, the doctor needs to understand the characteristic of every patient and oneself requirement adequately. For instance to young patient, their live time is very long still, and still have the demand of marriage Yo. The acerbity analogue of nucleotide of profess to convinced in fighting virus to treat medicaments is convenient, generally speaking short-term inside can see virus is duplicate by low-key effect, but the risk; that uses sick poisonous variation for a long time cannot do sth without authorization stops drug, have the possibility with exasperate disease otherwise. It is clear that this need and patient are explained, help the remedial cause with their reasonable set. Be based on the interferon cure of immune adjusting control, although can be being restrained,host immunity is brought into play while virus is duplicate, obtain taller E antigen to change rate thereby, after stopping drug opposite for it is treating; of not quite easy recrudesce medium deputy response is more apparent, and need inject cure, need a patient to cooperate very well, ability strives for first-rate curative effect. Liver of second of 2007 United States treats guideline middle finger to go out, to young patient, or the woman that has birth demand, suggest the disease-resistant poison of interferon of their first selection is treated. To oneself immunity system not be very good, or the patient that the disease has admitted liver cirrhosis, the life quality that treats the security that plan must want to consider treatment and patient. Next using is supervised in the doctor cure of analogue of nucleotide of profess to convinced, can help them maintain normal life. As the development that second liver treats, demand of immunity of oneself of medicaments, host, patient 3 person be united in wedlock apply processing to read aloud to be place of medical affairs bound to be agreed with extensively. Want virus of liver of thoroughly cleared second to not allow really easy, but clinical practice tells us, want ceaseless exploration only, chronic second liver is not a disease that does not have any hope conquer. (the exercitation edits: Plum apricot)