α interferon joins the opinion of manage application

One, of α interferon reach interferon of α of 　 of rational application 　 effectively to be used at treating chronic hepatitis B to already had old clinical experience, but its curative effect all the time cannot satisfactory, about this, I think to two problems need to solve: 1, the application of existing α interferon how reasonable, standardization? 2, whether can the curative effect of α interferon still rise further? How to rise? Bound of domestic and international medicine had a basic consensus already to the rational application of α interferon, but this one understanding still remains to be perfected further and complement. (One) get used to disease 　 all the time since, ALT of if of the person that we think HBV is affected is elevatory reach HBV to duplicating is α interferon cure point to proof, pass clinical application of these a few years in fact, be like next complement about getting used to disease: 1, ALT rises to be worth upper limit high normally more than 3, 5 times and be less than 10 times person 　 　 2, pathological change of liver organization inflammation is more apparent person (inflammation classifications in G2, G4) 　 　 3, without icteric or it is normal that serum bilirubin is less than be worth upper limit, 　 of 　 of the person that and not be be in ascendant trend (2) 　 of no-no disease 　 1, the countervail that miss generation 　 of 　 of period liver cirrhosis 2, whether does counterpoise of heavy-duty hepatitis 　 hepatitis use α interferon cure to still see difference of purpose at present, great majority expert thinks to need not be 　 appropriate. Additional, the person that chronic HBV is carried has 10% to control only because of the curative effect after cure, reason also thinks the unfavorable interferon that use α treats; as to because of before the patient of chronic second liver that C area mutation brings about HBeAg negative, foreign viewpoint is this kind of circumstance can alleviate in the illness when α interferon is treated, ALT can drop, virus is duplicate can decrease, but stop medical hind easy recrudesce, plant to this if the circumstance lengthens period of treatment the likelihood is effective, but of two years of period of treatment abiding businesslike still under 20% , in addition, still can consider to use thing of other disease-resistant bane jointly. (3) dosage of dosage, 　 of period of treatment: 5MU/ second, every week 3, hypodermic or intramuscular injection. The particular case of patient of Lv of the take an examination when cure if: Wait to the harmful response of interferon, sensitivity, treat plan to answer individual change. (4) harmful response and processing: 1, kind cold appearance reaction: Calorific and general mix gentlier briefer, can handle 　 　 to disease 2, marrow controls an appearance: Expression is cell of bead of end blood neutral and plaque to reduce. Think commonly L of μ of 50 000/ of plaque ≤ of L; of 1 500/ μ of ≤ of neuter bead cell, α interferon should reduce an amount. L of μ of 30 000/ of plaque ≤ of L; of 1 000/ μ of ≤ of neuter bead cell should stop drug. After reduce an amount or stopping drug, can restore. After restoring, can continue to use drug. Stop the person that cell of bead of the neutral after medicine and plaque still did not restore, should notice to do cellular inhibition to marrow, should make education of medullary dry cell, marrow does cellular subtracter, interferon of unfavorable application α is treated. Subtracter of cell of serious and neuter bead, market of usable bead cell falls exciting factor. 3, after applying α interferon, appear serious marrow is restrained, liver function aggravation appears icteric, spirit is restrained, oneself immunity disease is like thyroid disease to wait, answer to stop drug in time. 2, the research 　 　 that α interferon will treat henceforth 1, look at present with medical 　 jointly, the odd interferon that use α treats chronic hepatitis B, curative effect is not quite satisfactory, want to heighten curative effect further, the consideration is more now is to use drug jointly. α interferon combines other disease-resistant bane or immune adjustment medicine treats chronic second liver, from theoretic tell, should raise the curative effect, occurence rate that reduces virus mutation and harmful response. (A variety of medicaments couplet use 1) : Can use different motive target medicaments couplet is used, if fight virus medicine couplet,use, couplet uses disease-resistant bane and immune conditioning agent. At present α interferon combines rummy husband to decide, α of peptide of thymus of combination of interferon of Zun of virus of α interferon combination, α 1 etc, but curative effect all did not affirm. (2) order follow in a continuous line treats: Differ to disease-resistant bane presses foreword or treat by turns: Research is at present more decide for rummy husband with interferon α foreword be linked together is treated, preliminary report can raise disease-resistant poison the effect, virus mutation rate that reduces rummy husband to be caused surely and virus mutation cause be able to bear or endure medicine. 2, individual change remedial 　 different patient to have different remedial reaction to α interferon, accordingly we should adjust dosage and period of treatment according to the patient to the reaction 　 of medicaments. The dynamic change of the virus when abroad treats third liver to α interferon recently made relevant research, the metabolic cent of its virus after discovering third liver patient treats with α interferon is two photographs: Haemal photograph and constituent photograph, when the patient use α interferon treats 1-2 climate, the virus content in its blood drops quickly, the liver cell that virus infected after two days gradually die out, at this moment virus drops slower. The patient with different 　 of change of trends of HCV of serum of α interferon cure the change of these two photographs is distinct also, basically react the type has: General virus change is shown drop quickly model patient its are long-dated curative effect is better. Carry this research, different virus trends can appear to learn change as much after we assume patient of chronic hepatitis B is treated with α interferon, so we learn change to adjust dosage and period of treatment according to virus trends of the patient, perhaps can obtain better curative effect, that is to say the cure of liver of slow henceforth second should notice individual the issue that turn. (the exercitation edits: Plum apricot)