Interferon disease-resistant poison treats hepatitis truth

Interferon is a kind of very important immunity conditioning agent, it can enhance the active of immune cell apparently, stimulative immunity cell is right the cleared action of virus. Of interferon make the direct disease-resistant toxin that still can protecting the cell that did not infect to avoid poison of catch a disease catch a disease to affect is interferon the 　 of; of action of immune adjusting control that action; interferon still has antagonism virus to affect actually, everybody has felt the effect of interferon more or less, in suffer from " cold " when, a lot of people can have a fever, all over ache, these affect the symptom that the generates naturally interferon inside flu virus rear body causes namely, there also can be this kind of symptom in the process that treats with interferon, say on medicine for " flu appearance symptom " . The interferon of development course 　 of interferon basically is generated by human leucocyte and secrete, of inchoate interferon getting is to carry revulsive kind, collect the leucocyte in human body blood, undertake extracting through rarefied technology. Because pass this kind of means to draw source of interferon raw material very finite, extraction quantity is very few, together with contains a lot of impurity, have apparent antigen sex, not only action is limited, and still can bring a lot of secondary action because of purity inadequacy, restricted its thereby clinical application. To last centuries 70 time metaphase, recombine technical occurrence as the development of biology medicine and gene, the technology that scientists begin to try to recombine through gene will synthesize interferon. 1978, CDNA of interferon of successful clone of Pestka of scientist of company of Swiss collect family name, consider to succeed product of interferon of project of the first gene. The interferon that generation recombines a technology to produce with gene is called now common interferon. This kind of common interferon because half-life is too short, in blood chroma is not stabilized, the chroma after inject rises very fast, but drop very fast also, the side effect when chroma is exorbitant will be too big, corresponding remedial effect does not have again when density is too low, its are clinical application gets accordingly very big limitation. 90 time end reachs 20 centuries at the beginning of 2000, get together glycol is changed (the development of the element of occurrence desiccate faze of PEG) technology had brand-new breakthrough. Get together the molecular amount that glycol spends element of technical desiccate faze gets increscent, half-life gets be extensioned apparently, hematic drug chroma becomes more stable, clinical curative effect is able to rise apparently. Because get together,at the same time glycol element pays chain the protective action to interferon, its antigen sex is reduced greatly, side-effect also is reduced apparently. This kind gets together the glycol interferon effective treatment in blood commonner interferon extends chroma hold time apparently, especially macromolecule gets together glycol interferon α - 2a, chroma of effective blood drug can be stabilized after inject last a week, be called by common ground accordingly " lasting effect interferon. Advantage 　 interferon is shown to be applied at the cure of virus sex hepatitis gradually in cure of virus sex hepatitis, show its peculiar advantage in third hepatitis and hepatitis B cure. 1991, american FDA approves interferon α to be used at treating third hepatitis;1992 year, interferon α is approved to be used at treating hepatitis B;2002 by FDA year, get together glycol interferon α - the remedial;2005 that 2a is approved to be used at third liver by FDA year, FDA formal approval gets together glycol interferon α - the treatment that 2a uses Yu Yi liver. Current, the core that interferon grows effect interferon to already became virus sex hepatitis especially treats medicaments. A large number of clinical research show, lasting effect interferon is used at treating chronic third hepatitis, can make 4 obtain into the patient clinical cure; to grow effect interferon and Libaweilin to be used jointly, more make clinical cure rate raises third liver 73% . Because curative effect and security are high,this kind of combination treats plan, by " guideline of prevention and cure of Chinese third liver " recommend the first selection program that is remedial third liver. Interferon is ceaseless also in the cure to chronic second liver bring joyance to people. Evidence of abide card medicine confirms, the E antigen that those suit to use lasting effect interferon is electropositive second liver patient, if can hold to cure one year, the person of above of the half the number in them can achieve E antigen serum to change (turn shade) ;E antigen turns if the patient of shade continues to treat half an year with lasting effect interferon, the person that there is 10% again in them can realize exterior antigen (bay fight) turn shade, partial person still can appear exterior antibody turns in relief. Because grow effect interferon not only the effect that has direct confrontation virus, and through adjusting virus of control of airframe immunity system duplicates, still can restrain virus continuously after stopping drug, reduced illness recrudesce thereby. Really, also have research discovery, the patient of chronic second liver that has 1% about can appear bay fight nature to turn shade. But this kind of nature turns shade is to happen after course of diseases is controlled 20 years continuously commonly, in those days, because be damaged for a long time by virus, the patient already produced hepatic sclerosis mostly. Because of quality of this health to the patient, life and life character, through using interferon active cure obtains bay fight turn shade and nature turn shade, what its meaning is having essence is different. Introduce according to experts, look from long-dated curative effect, multinomial those who be as long as 10 years along with visit research to still confirm, interferon treats chronic hepatitis to be able to lower the occurence rate of liver cirrhosis and liver cancer significantly. Interferon treats a respect to have an advantage in virus sex hepatitis not only. People is studying to interferon the process is medium, still discover it has certain inhibition to the growth of tumor, be applied at the cure of a variety of tumour such as cancer of leukaemia, kidney, cystic cancer, melanin tumour consequently. In addition, be based on interferon to have to immune system adjust action, it still is applied at a few otherer the cure of immune dependency disease, if send sexual sclerosis and disease of sex of infection of a few bacteria more,wait. Experts are opposite while interferon gives height the opinion, point out, interferon in use also can arise have certain and undesirable reaction, the patient appears besides the likelihood calorific, myalgia, shiver, disgusting outside waiting for flu appearance symptom, appear likely still trichomadesis, leucocyte drops, depressed etc. Nevertheless this kind of harmful response is to be able to be able to bear or endure suffer and reversible. If appear harmful response, can decrease appropriately with dosage, but had better not stop treatment. (the exercitation edits: Plum apricot)