Vaccinal to second liver irresponsive " deaf-mute "

Because have not discover the specially good effect of second liver treats a method at present, the immune strength that gains pair of second liver virus appears particularly important. Since second liver vaccine after development comes out, the person that our country adds second liver newly every year to affect already dropped from the 260 thousand person 1980 the 78 thousand person 2001. Our country Ministry of Public Health plans immune management at bringing into hepatitis B vaccine 1992, to all new students vaccinal hepatitis B is vaccinal, but vaccine and charge of its have an inoculation need to pay; to bring into plan immunity formally since 2002 by the parent, to all new students free and vaccinal hepatitis B is vaccinal, but need to pay have an inoculation to expend; to remove instead from June 1, 2005 all and free. This overall to our country control went to main stimulative effect since second liver popularity. Do not have to second liver vaccine respondent " deaf-mute " generally speaking, after inject second liver is vaccinal, second liver vaccine can stimulate airframe immunity system, "Call " the particularity antibody that gives pair of second liver virus, make airframe generates strength to second liver. Such, once virus of liver of second of bring into contact with, won't be affected by it. Somebody statistic, vaccinal after the 1st needle is vaccinal, the person of 48% produced 30% ～ antibody, the person that antibody produces after the 2nd needle rises to 78% ～ 90% , the person that antibody produces after the 3rd needle can amount to 90% ～ 96% above. Accordingly, second liver vaccine needs have an inoculation 3 times at least. But always have 4% ～ 10% right-and-left people are in second liver is vaccinal 3 " call " later, still detect the antibody that is less than airframe to should arise originally " respondent " , it may be said is not had to second liver vaccine respondent " deaf-mute " . Anatomize these " deaf-mute " the account that produce has a lot of. Distinguish true and false " deaf-mute " 　 these " deaf-mute " in, some are not true, occupy 3% ～ about 5% . A few people are after vaccination, generation antibody is too little, use detect commonly the dosage that the method cannot measure a; to because vaccine is vaccinal,return a likelihood is insufficient, the antibody; that cannot make airframe generation enough perhaps has some of person to once had injected vaccinal, but detect not in time, the time that antibody appears is too short, when detect antibody has disappeared the vaccine that; used be no longer in force likely still, this cannot achieve exciting airframe to produce the effect of antibody of course. These people are not pair of true second liver vaccine " pretend to be deaf and dumb " , should increase vaccinal dosage only or inject again, the immune system of airframe can hear second liver vaccine finally " call " , arise respondent. Infection of potential second liver virus is in in our country adult, vaccinal to second liver " call " there are 2% ～ about in having respondent 3% it is the person that virus of potential second liver is affected. They may be not to measure those who give the infection of second liver virus that fights HBs " window period " , virus of liver of the mutation that also may be HBsAg negative second is affected, still be HBsAg false negative likely. Because they had contracted second liver virus, vaccinal to second liver " call " show immunity to be able to bear or endure suffer, won't arise consequently " respondent " . It is OK that genetic element builds didymous second liver not to have respondent a little genetic element vaccinally cause airframe to become pair of second liver vaccine to not have respondent " deaf-mute " , occupy 1% ～ about 2% . For example: Airframe participates in the gene area with respondent vaccine of control second liver to be located in " akin leucocyte antigen (HLA)- immunity reaction is relevant gene area (DR area) " , if the transmissibility blemish of this gene area, become pair of second liver vaccine likely to not have respondent " deaf-mute " . Still have, the ability that the person that certain immunity function is damaged reacts to second liver vaccine is poorer, be like disease of a kind of transmissibility -- it is normal that Tang asks for a patient integratedly to be compared to vaccinal respondent ability the person is low. Second liver is vaccinal " deaf-mute " these are opposite countermeasure second liver vaccine is not had respondent " deaf-mute " , although vaccinal second liver is vaccinal, but still do not have immune force to second liver virus. Accordingly, cannot think inject crosses second liver vaccine to won't affect second liver, return what should undertake second liver antibody after vaccination to detect, find out these " deaf-mute " , strive for these as far as possible " arouse " these " deaf-mute " vaccinal to second liver " respondent " reaction, ability achieves the goal that prevents second liver. Discovery is not had to second liver vaccine respondent " deaf-mute " hind, ought to discern above all whether its are really " deaf-mute " . Can pass more advanced detect the method detects antibody, if be antibody drop,spend inferior, can pass increase vaccinal dosage or increase vaccinal number, exciting airframe is vaccinal to second liver respondent. If contract the disease with immune low ability, also can pass have an inoculation for many times, perhaps use immune intensifier jointly, make airframe produces antibody. The person that only potential of those second liver virus are affected cannot pass vaccine of vaccinal second liver to produce antibody. Anyhow, detect even after vaccinal second liver is vaccinal whether antibody of enough second liver surface appears, do not have to second liver vaccine respondent " deaf-mute " , should prove a cause, treat respectively, improve the immune result of second liver vaccine. (the exercitation edits: Plum apricot)