Remedial second liver need not two medicine couplet is used

Because the patient is numerous, the progress of medicaments of concerned second liver all the time since get everybody's attention. Among them, nucleotide kind of disease-resistant bane content appear, it is a huge success undoubtedly, patient of liver allowing second benefits a lot. However, as the extension of use time, virus is right of this kind of medicaments be able to bear or endure medical problem also begins to be exposed gradually, how to break through this one bottleneck to become a difficult problem that puzzles treatment of patient of chronic second liver. Overcome be able to bear or endure medicine has two crucial 　 normally for, defy when virus through mutation when the remedial effect of medicaments, be able to bear or endure with respect to what can produce medicaments medical reaction. This is met not only abate and current medicationed effect, make the optional medicaments when future is treated possibly still a lot of less. Committee member of chairman of reputation of branch of catch a disease of move of China cure society, Fudan University is accessary division Professor Weng Xinhua points out contagion of Mount Hua hospital, overcome virus be able to bear or endure property of a medicine can begin to control from two respects at least, it is firstly can " powerful effect falls virus " ; is to build secondly " be able to bear or endure high medical gene protective screen " . Alleged " powerful effect falls virus " , it is to point to in fall HBV DNA numerical value of the patient inside short time as far as possible, make effective control virus duplicate thereby. "Be able to bear or endure medical gene protective screen " be just like a wall. To a few medicaments, appear when virus gene a mutation of the dot when, be able to bear or endure with respect to meeting generation property of a medicine, for instance rummy husband is decided, if; of A Defu Wei can be controlled have the many gene in virus only generation of the ability when the dot mutates at the same time is able to bear or endure property of a medicine, be equivalent to making this block wall heighten up a lot of, this is so called " be able to bear or endure high medical gene protective screen " . Favour the Wei Naiyao that replace card is less than 1% 　 clinical trial makes clear, favour for Ka Wei (rich road is decided) in nucleotide kind have in the patient that treats at the beginning of medicaments be able to bear or endure high medical gene protective screen, make virus arises very hard to medicaments be able to bear or endure medicine, favour be able to bear or endure for what block Wei 3 years medical occurence rate under 1% . This gives those to decide generation to be able to bear or endure to rummy husband undoubtedly second liver patient of medicine brought new hope. Weng Jiao awards the introduction, favour have for Ka Wei " one tall one low, it is better to be treated first " characteristic. "One tall " it is finger height effect, it is the medicaments with the at present strongest result of virus of antagonism second liver, can reduce HBV DNA level significantly. "One low " it is to point to be able to bear or endure property of a medicine is very low, because it needs virus 3 nod coinstantaneous mutation to just can arise be able to bear or endure property of a medicine. Weng Jiao is awarded say, an odds of a dot happening mutation is probably 50 thousand 1/0, and 3 an odds that nods coinstantaneous mutation be in 1/-1530494976 the left and right sides, this also is why favour the Wei that replace card is able to bear or endure inside 3 years medical occurence rate under the reason of 1% . "It is better to be treated first " it is to point to, cross nucleotide to never be being taken kind the patient of medicaments, it is very appropriate that choice favour replaces Ka Wei. Data shows, to the patient of E antigen positive, accept favour after treating 24 weeks for Ka Wei, the patient virus of 45% carries a quantity to achieve detect the HBV DNA of;97% patient falls under the level 105 copies / milliliter is the following. Do not need two medicine couplet to should say with 　 , it is home or abroad no matter, the remedial problem to chronic second liver is take seriously to. By 2005, our country was rolled out " guideline of prevention and cure of chronic hepatitis B " , august 2006, the United States also edits again published latest edition " American second liver treated a guideline 2006 " (the following abbreviation " guideline " ) . Of the United States " guideline " put forward, the cause that chronic second liver treats is should be eliminated or from go up at all those who restrain second liver virus is duplicate, say from this meaning, made clear namely " powerful effect falls virus " meaning. And favour the Wei that replace card because its " powerful effect falls virus " and " extremely low be able to bear or endure medicine is led " characteristic, be labelled to be the admirable choice that chronic second liver treats. Decide generation to be able to bear or endure to rummy husband when the patient medicine, when changing the Defuwei that use A, the two medicine couplet that needs period of time is used, in order to assure the continuance of medical effect. But favour the action that replaces Ka Wei is quicker, change medicaments couplet does not need to use when using. Weng Jiao is awarded think, favour serve as for Ka Wei " powerful effect " medicaments, want economic condition to allow only, can only drug is used. (the exercitation edits: Plum apricot)