Second liver uses drug: 1 may not of 1 ＋ is more than 1

I am patient of chronic second liver, want to use remedy of virus of 3 kinds of two liver that fight second very much, although want a few more floriferous money, but I hope to be cured quickly more. But the doctor that treats for me not quite agree with this one requirement. Excuse me, had medicaments of a variety of virus of the liver that fight second applied jointly? 　 of Liaoning plum gentleman discovers in clinical work, a variety of fighting hepatitis B virus (application of HBV) medicaments combination is not scarce, a lot of people are very tall to this expectation value. Think, action of all sorts of disease-resistant bane content at HBV the point is different, if one kind fights virus drug action the certain at HBV dot, so two kinds fight HBV medicaments with respect to action at two dot, of action the dot is more, fight HBV action to ought to be jumped over strong, like be just as 1+1>1. But reality not so simple, bring undesirable consequence even sometimes. Fight HBV medicaments to 5 kinds of 　 have fight HBV medicaments to have two kinds big 5 kinds: It is interferon kind, include common interferon, get together glycol changes interferon (lasting effect interferon) ; 2 it is nucleotide analogue, include rummy husband to decide, Adefuwei and favour replace Ka Wei. Place of ill expert of whole world liver approbates these 5 kinds fight HBV medicaments, also got national provision medicines and chemical reagents supervises the approval of management board. Additional, our country still developed suffering to join white. A few kinds of afore-mentioned medicaments, besides common interferon, other fight HBV medicaments to be in clinical application time of home is not very long, experience still does not calculate rich, especially the appropriate period of treatment that nucleotide analogue refuses HBV was not made clear all the time, "Want to apply 1 year at least " , but should apply how long after all, did not reach consensus domestic and internationally. The main purpose that uses drug jointly has 3: It is to add curative effect, place has synergism with medicaments, 1+1 ≥ 2; 2 it is to reduce side-effect; 3 it is to reduce virus to be able to bear or endure medical occurrence. Use afore-mentioned combination that fight HBV medicaments to undertake differring at clinical, through these year exploration, observation, research, the result is disappointing, did not show the dominant position that uses drug jointly, did not see heighten curative effect apparently. Do not abuse medicaments to combine 　 to study more is husband of interferon combination rummy domestic and internationally calm, couplet is valued for a time with foreground, the report thinks to be able to heighten curative effect, the variation that can be deferred or reduces HBV (YMDD mutation) , up-to-date domestic and internationally still this kind of combination reports with medicine. But contrast through big sample book, much center, double blind research, pass statistical processing, integrated and respondent (remedial effect) difference is not notable, especially long-dated curative effect more without the advantage. The associated application between nucleotide analogue (rummy husband is decided + ) of A Defu Wei, turn to HBeAg shade, fight - HBe this world turns, HBVDNA shade turns to contrast with a kind with sheet group also do not have notable difference quite, the inhibition that cannot increase pair of HBV strength. Come so, people took sober attitude to using drug jointly, understanding rose. " guideline of prevention and cure of chronic hepatitis B " (abbreviation " guideline " ) point out clearly, do not recommend rummy husband to combine interferon to treat second liver surely, also do not recommend rummy husband to combine Adefuwei to be used at chronic hepatitis B surely be treated first and did not produce rummy husband to be able to bear or endure surely the patient that medicine mutates. " guideline " operable to other couplet medicine, be like interferon + Chinese herbal medicine, rummy husband is decided + Chinese herbal medicine, fight HBV drug + thymus peptide α 1 wait to also support cautious attitude. Foreign expert also does not recommend the couplet that does not have a meaning to use. The scholar begins to study treatment of order follow in a continuous line again, if use rummy husband to decide 20 weeks first, add again with interferon 4 weeks, again odd finally with interferon 24 weeks, after cure ends, HBVDNA shade turns rate achieve 56% , HBeAg/ is fought - HBe changeover rate is achieved 45% , the result is right. Therapeutics of another order follow in a continuous line is: Use first get together glycol changes interferon 8 weeks, add again next decide with rummy husband, both couplet uses 24 weeks, final sheet decides 28 weeks with rummy husband, common 15 months, liver of electropositive to HBeAg second obtained very good curative effect, virus learns respondent rate to achieve 60% . But, therapeutics of follow in a continuous line of this kind of order is not quite mature still, still need to have more test and verify. Accordingly, remind broad patient here, do not abuse medicaments to combine, the price that fights HBV medicaments is higher, insignificant combination uses medicine to be able to waste medical source, increase a burden, also meet those who increase the harmful response of medicaments and HBV be able to bear or endure at the same time medical individual plant appears. (the exercitation edits: Plum apricot)