Slow liver optimizes remedial new strategy

Roll out ceaselessly as what fight new drug of second liver virus in recent years appear on the market, chronic second liver (before curative effect has compared 3 years, the cure of CHB) has improvement greatly. From the nucleotide analogue that appears on the market in our country in succession since 2005 Adefuwei, favour replaces Ka Wei, and just appeared on the market this year for decide than the husband, decide one case with first rummy husband, built nucleotide analogue to treat the strong ammunition depot of second liver. Additional, besides nucleotide analogue, the interferon of disease-resistant bane content that liver of another kind of chronic second treats also grows effect to get together at was being rolled out in recent years the form of a drug that glycol changes, commonner interferon heightened curative effect further. A few days ago, chronic second liver treats the rising market that holds in island of Korea aid city on politic seminar, professor Edward Gane of Oakland of international liver ill expert, New Zealand put forward chronic second liver individual turn treatment optimize new strategy, combine chronic second liver to treat line attempt namely, the assessment that has curative effect regularly medications with adjusting plan, optimize the cure of chronic second liver thereby, decrease to prevent patient patient's condition to make progress to wait for long-dated complication to liver cirrhosis, liver cancer even. The institute of research of Asia-Pacific liver disease that holds at Japanese Kyoto before this (APASL) on the seventeenth annual meeting, the international liver ill expert that attend the meeting combines chronic second liver to treat line attempt, and will study association by American liver disease Feburary (the latest edition that AASLD) publishs " guideline of second liver prevention and cure " had sufficient communication. One of main apiration that they reach are: To initiative cure patient, from cure at the beginning with respect to appropriate preferential choose disease-resistant poisonous ability strong, be able to bear or endure the medicaments with medical low rate. Announce in the academic activity of the near future, more and more research make clear, to the cure of chronic second liver, when curative effect of a kind of medicaments not beautiful (if treat half an year,still cannot fall level of second liver virus effectively to lowest) when, change another stronger kind in congener medicaments to fight virus action, can restrain virus effectively, if control virus standard to the level that does not detect. And if initiative cure uses thing of bane of powerful effect disease-resistant aptly, the level falls lowest, promote transaminase effectively answer often mix HBeAg serological changeover, reduce be able to bear or endure medical happening, achieve thereby continuously the purpose of curative effect. Concerned expert expresses, analogue of existing 4 kinds of nucleotide and different interferon preparation, to solve a variety of dilemma of cure of chronic second liver, like curative effect not beautiful, HBeAg turns shade rate on the low side, be able to bear or endure medical occurrence, and to security be anxious to wait, provided a variety of assorted application measures. The doctor can change according to specific illness of the patient, use individual the treatment that turn. Be like, level of virus of liver of base line second is higher, namely second liver virus duplicates in great quantities inside body, if the medicaments that can choose poison of powerful effect disease-resistant is replaced decide than the husband, favour replacing patient of Ka Wei; is " big 3 this world " , be faced with the consideration such as enter a higher school, obtain employment, need turns HBeAg shade arrives " small 3 this world " , can consider to turn the interferon with shade higher rate or for the security aspect that decides; to fight virus for a long time to treat in the consideration than the husband, can consider to choose what the rummy husband with more experience of longer, application is decided or the only in nucleotide analogue obtains class of American FDA gravid B to maintain to use time already for decide than the husband, also can choose be able to bear or endure medical occurence rate is low and the favour with harmful response not high occurence rate replaces Ka Wei. When refer interferon is treated, professor Gane points out, the patient treats a lot of condition of base line, the discretion that is like the age, sexual distinction, transaminase, discretion of level of second liver virus, the curative effect to interferon can produce apparent effect, this one viewpoint has been approbated extensively by academia. And the clinical research that uses nucleotide analogue to treat chronic second liver makes clear as a result, for treat surely than the husband " big 3 this world " patient, in the patient that is more than double normal value in level of transaminase of remedial base line, curative effect is much better; can make with medical half an year the patient of 49% achieves level of second liver virus to detect when be less than; and treating two years, the level of virus of patient second liver of 86% continues to keep electronegative, the patient of 49% came true " big 3 this world " turn " small 3 this world " , the patient transaminase of 85% returns to normal. According to the viewpoint of the multinomial research report of the near future and relevant guideline, it is A to genotype of second liver virus model with D model patient, the curative effect of interferon with respect to excel B model with C model the genotype of patient; patient is right the curative effect of nucleotide analogue is main without the influence. Additional, although chronic second liver needs long-term disease-resistant poison to treat, but " big 3 this world " the patient's period of treatment and " small 3 this world " the patient differs somewhat again, if need,treat for a long time so, what one of main factors that the security that medicaments uses for a long time must regard a consideration as choose medicaments in; cure process whether powerful effect, fast restrain virus to arrive do not detect, and whether to have tall E antigen to turn shade is led / changeover rate is the key that must pay close attention to when doctor head examine. (the exercitation edits: Plum apricot)