Second liver treats " at 3 o'clock type "

"At 3 o'clock type " , exploration second liver is treated " 5 bottoms hole " 　 says " at 3 o'clock type " , almost ground of metropolis understand tacitly laughs at everybody. This is none strange, the sexy look that because the first reaction of everybody thinks of a female namely,wears underwear or swimsuit. But nowadays, "At 3 o'clock type " was gifted in domain of second liver cure however new meaning. So called " at 3 o'clock " , those who point to is the start that second liver treats, inflection point and terminus, expert play call his " at 3 o'clock type " . Start, those who point to is the condition at the beginning of treating, include E antigen negative or level of DNA of numerical value of electropositive, transaminase, virus. Terminal, those who point to is the day mark that should reach. As to inflection point, it is us the topic that this secondary speaks of mainly. Be fought by the second liver with accepted international now virus medicaments, cent is nucleotide kind all alone with interference kind. Among them nucleotide kind medicaments all is profess to convinced, use convenient, disease-resistant poisonous effect is relatively rapid. However, nucleotide kind the defect of medicaments is period of treatment very not fixed, and appear easily be able to bear or endure medicine. Use all the time so, whether can see a hope, achieve a goal, doctor and patient do not have a bottom in the heart. No matter which be,plant now normal disease-resistant bane, expenditure is not low, even if the cheapest rummy husband is decided, the expenses for medicine of a month also wants 500 yuan or so, the charge of other remedy is a go even farther than more. And " big 3 this world " the patient uses nucleotide kind disease-resistant bane wants two years at least, "Small 3 this world " the patient's period of treatment is longer, the person that curative effect owes beautiful still must continue to use drug, when can stopping still is unknown. So, partial person calls second liver cure helplessly " a bottomless pit " . Whether what treating is inchoate can calculate the curative effect henceforth, undertake adjustment to using medical program thereby? Whether spring was sowed kind, summer can forecast harvest, and need not when the autumn. Really, the remedial program of patient of chronic second liver needs to get optimizing, we use medical hind to proper time to the patient, must carry particular index, undertake assessment to curative effect, calculate long-term henceforth therapy effect thereby. This time place is in front mention " inflection point " , its meaning depends on: After treating period of time, calculate the curative effect that continues to go down with this drug treatment will how, it is benefit still be fraud more much, appear be able to bear or endure medical possibility has how old. "Inflection point " it is very important. It can make the patient is below doctor guidance, add use or change with other remedy. Now, the academia puts forward " circuitry of second liver cure pursues " concept, basically be a patient disease-resistant poison remedial half an year (24 weeks) the virus DNA level after, as decision-making dot, will forecast the result when cure mixes two years one year. If level of DNA of the virus after remedial half an year is lower, the following curative effect is better; If treat hind of half an year, virus DNA level cannot fall low-level, can consider to change remedial strategy, in order to achieve long-dated better curative effect and lower be able to bear or endure medicine. After treating 24 weeks, detect virus DNA level, have 3 kinds of results: Completely respondent (show with PCR the method does not detect give virus DNA) , the part is respondent (detect a virus, DNA is less than 104 copies / milliliter) , inadequate respondent (virus DNA is more than 104 copies / milliliter) . To completely respondent patient, need not change remedial plan, and Ding is lengthened along with visit interval, patient also should sturdy confidence, the cure that finish; To the patient with respondent part, can strengthen along with visit or consider to adjust remedial plan; To inadequate respondent patient, drug can be added below doctor guidance or change medicine, in order to achieve better curative effect, shorten along with visit interval. One replaces the global research report that decides than the husband to show about content of bane of second liver disease-resistant, treat 24 week hind, if level of DNA of second liver virus passes PCR method not to detect,go out, criterion the patient continues to treat after coming two years, DNA of virus of implementation second liver does not detect, the opportunity that liver function returns to normal is greater, the patient appears be able to bear or endure medical chance is less. Among them, electropositive to E antigen patient (namely " big 3 this world " ) , 46 ％ can obtain E antigen to change (namely E antigen turns shade, e antibody appears) . Conversely, when be like the 24th week, the DNA of second liver virus in blood is more than 104 copies, milliliter, adumbrative cure the effect after two years is poorer. Nucleotide kind content of bane of second liver disease-resistant, appear to be respectively orderly early or late by its: Rummy husband is decided, ester, favour replaces Adefuwei Ka Wei, for decide than the husband. At present besides for outside be being decided than the husband, other 3 kinds of nucleotide kind disease-resistant bane content, what fight virus according to its is strong weak, be able to bear or endure the morning and evening of happening of property of a medicine, have place of a time possibly also, but did not have relevant research before, still lack relevant data temporarily. As to lasting effect interferon, use at third liver is treated, the time that has an apparent judgement prognosis is nodded -- 12 weeks, but with Yu Yi liver treats a field, the time drop that can forecast long-term curative effect returns cannot to know temporarily. (responsibility edits: King sea E)