Conquer is chronic of second liver " fighter "

Normal human body is in when be affected by virus, the meeting inside body produces the material of virus of a kind of antagonism, fighter of elephant of this kind of material is same, not only OK and direct counteractive virus, and the immune function that can improve human body, promote airframe to kill virus finally thereby, conquer disease. This kind of material is α interferon. α interferon has disease-resistant poisonous action, immune adjustment effect not only, still have fight fiber to change intention, fight tumor action. Current, clinical use α interferon has 2b of 2a of α 1b, α , α 3 kinds. The dosage of interferon of 2a of α 1b, α is used normally " international unit " will express. This kind states the method has certain limitation. Because, above all international unit is interferon pointing to α merely " disease-resistant poison is active " , and cannot mirror other active (if fight tumor active, immune adjustment active to wait) ; next, international unit cannot mirror α interferon the; of practical curative effect inside human body is additional, on different cell, detect the interferon active that go out is different, cause a disorder easily. Accordingly, at present medicaments of most gene project all uses weight to regard dosage as the unit on international, its curative effect also depends on just about weight (namely) of actual protein content. If the dosage of α 1b interferon is every 10 microgramme, 30 microgramme, 50 microgramme. α interferon is clinical applied field is very extensive, but the commonnest is the treatment that is used at chronic hepatitis B. The disease-resistant poison that it is first selection of chronic second liver treats one of medicaments. Patient of chronic second liver if transaminase prep above is normal or liver organization has apparently chronic inflammation, suit to use α interferon treatment. Want to choose correctly to get used to disease and standard to use α interferon only, when period of treatment ends, the patient of 50% can achieve about 40% ～ completely respondent, expression returns to normal for transaminase, HBV-DNA turns antigen of shade, E turns antibody of shade, E turns in relief. Like ill institute of Shenzhen city liver Professor Ma Weimin applies α 1b interferon (Sai Rejin) treat chronic second liver, every time 50 microgramme, daily, the instead after half month is tertian one, period of treatment 6 months. When period of treatment ends, after the patient of 55.3% achieves completely respondent; to stop drug one year, check, the patient that still has 50% keeps completely respondent, curative effect is stable. After period of treatment ends follow for a long time visit discovery, α interferon is returned can the development that changeover or block stop liver fiber to change, lower the occurence rate of liver cirrhosis and liver cell cancer, improve life quality, lengthen live period. If Fudan University is accessary,professor of prosperous of Zhongshan hospital introduced from the northern and western nationalities or from abroad heart summed up α 1b interferon (Sai Rejin) 50 microgramme treat 30 ～ of curative effect of chronic second liver follow for a long time visit (2 ～ 10 years) case of illness, discovery uses the patient that α 1b interferon treats, as the extension of time, not only completely respondent rate rises ceaselessly, and the occurence rate that liver fiber changes also greatly under the patient that did not use α interferon treatment. Abroad studies the data also shows: The patient of chronic second liver that use α interferon treats, treat the 5 ～ after the end 10 years, the occurence rate of liver cirrhosis, liver cancer drops greatly. The problem that should note in cure: 1, cereal third transaminase (after ALT) spends week of the 5-8 after the gender lifts interferon of 　 　 α is treated, respondent patient often appears ALT is elevatory, some patient expression are wave motion of sex of ALT level level. System of this report immunity is activationed, airframe is keeping clear of the liver cell of infection. The 3-4 after be being treated commonly lunar ALT returns to normal namely and accompany those who have E antigen and HBV-DNA to turn shade. ALT is elevatory clew prognosis is normally better, do not advocate give fall enzymatic medicine. But if appear icteric, should interferon of α of out of service, wait for icteric disappear drop back to continue to use α interferon again. 2, the side effect that during interferon of side-effect 　 all α uses drug, causes is reversible, after stopping drug namely, can restore. Common side-effect is the symptom that similar cold appears after inject counts a hour, be like shiver, calorific, lack of power, have a headache, limbs ache, arthralgia, muscle painful, disgusting, heart-throb. Most patient continues to treat the meeting after period of time to be reduced gradually again. If these side effect are more serious, solution can be used to heat up demulcent medicaments head in hour of the 2-4 after inject α interferon, also but inject timeline in the late evening, in order to relieve a symptom. Other deputy reaction is like trichomadesis to wait, the meeting after stopping drug returns to normal gradually, need not handle temporarily, also need not change the remedial plan of α interferon, lest affect curative effect. Of leucocyte of the week outside seldom counting a patient to appear and plaque reduce, if lower rate heavier stop drug temporarily, after stopping drug, can restore by oneself mostly, can add when necessary use litre of leucocyte drug or rise plaque medicine to be handled to disease, after returning to normal, can continue to use α interferon. (the exercitation edits: Plum apricot)