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Tuesday 11 September 2007

Second liver pays attention to 4 with medicine " proper "

At present second liver cure still puts a lot of unreasonable cases that use drug, according to not complete count, clinical on have 20% ~ patient's condition of patient of 30% second liver is aggravating, with unreasonable concern with medicine. Because many patients are treated by accident, treat in disorder and " autonomy " bring about an illness to accentuate. The reasonable need that use drug masters remedial second liver " 4 basic principles " , this " 4 basic principles " be: Exquisite security treats second liver to want to emphasize security above all with medicine, multiterminal of change of patient's condition of second liver patient, period of treatment is endless, onefold achieve remedial goal hard with medicine, use associated treatment more now, the safety that use drug is principal. Old previously, a variety of hepatitis that once used use drug, be confirmed to be insecure later, for example formic acid of A candy adenosine, phosphine, cause kidney function likely to damage. Husband of the interferon that uses at present, rummy waits surely, if use undeserved, put in serious safe hidden danger likewise, choice case of illness undeserved or do sth without authorization stops medicine to bring about illness accentuation possibly. Chinese traditional medicine is the most safe medicaments in people memory all the time, actually Chinese traditional medicine also is existing insecure element, many Chinese herbal medicine and Chinese traditional medicine preparation, be confirmed to have apparent caustic liver effect, for example cane of the achene of Siberian coklebur of Chinese herbal medicine, the rhizome of cyrtomium, Thunder God, the root of Chinese trichosanthes, nutmeg, mint, plain Lian child in waiting; a moment officinal have Xiaochai nucleus of bolus of Qing Dai of Hu Shang, compound, disappear piece, the bolus that overcome silver. Certain Chinese traditional medicine has the dualism of pharmacodynamics action and poisonous manage action, even its active ingredient is its noxiousness composition, be not all Chinese traditional medicine so is safe, even if is the pharmacodynamics character that use Chinese traditional medicine also wants to understand every kinds of Chinese traditional medicine above all, avoid to abuse and exceed period, exceed a quantity to take Chinese traditional medicine. To civilian proved recipe, folk prescription must careful with, in case toxic. All sorts of new drug use time not to grow, long-dated curative effect and harmful response still are not clear about, liver result, blood picture must be monitored to wait regularly in use process. To having drug allergy before history or the patient of allergic constitution uses drug must careful, once appear,medicaments sex liver is damaged, must disuse this medicaments, head for normal hospital in time to make a diagnosis and give treatment. Pursuit effectiveness is used medication must emphasize its effectiveness, alleged effectiveness must be accepted with what make clear, cannot be specious. Obtain lot number formally to be in at present clinical use remedy has hundreds to plant, the without approval second liver medicaments in clinical try out by tens of thousands, but the curative effect that has a few remedy only among them gets accepted, that is to say great majority medicaments does not have practical curative effect. Old drug of liver of not little now second already was confirmed to be invalid, for example glucoside of the Wei of the name of a river in Shaanxi and Henan provinces of former times of the interferon of profess to convinced, extensive, island that do not have annulus, already washed out; gradually now although a few new drug obtain approval article date or clinical try out to approve, but curative effect is very finite, become so called " new drug rubbish " . Regard cure as second liver at present advocate make remedy -- medicaments of virus of the liver that fight second, accepted only husband of interferon, rummy is decided, Adefuwei a few kinds, all sorts of other flaunting the remedy that has effect of virus of the liver that fight second, have not get accord admissive. Additional, thousands of planting alleged " the medicaments that protect liver " , only one part has improvement the liver result, effect that reduces hepatic inflammation reaction, for example spirit of Ganlixin, hepatitis, great majority " the medicaments that protect liver " the action that protect liver also did not get accepted. So the patient uses drug, must choose seriously, ten million cannot cursory, first-rate makes sure measure wants normal specialized subject hospital to see a doctor namely, 10 thousand cannot light trustful He An is accused and all sorts of conduct propaganda. Advocate economy to treat second liver new drug sort is various, period of treatment is endless, lack the medicaments of specially good effect of give the decisive word, patient's condition of second liver patient is capricious, with medicine ceaseless, many patients had sent deficient due to illness. Accordingly second liver patient uses drug must careful calculation and strict budgeting, little flower treats unjustly money, have for example protect liver to fall the medicaments of enzymatic property is very much, when the doctor chooses to use drug, must bear considering patient economy ability, goods compares 3, choose good in quality and cheap in price medicaments. Contain licorice likewise sweet the medicaments protecting liver of element, sort is very much, curative effect close, price difference is very big however, common people emphasizes with medicine good in quality and cheap in price, in congener medicaments, fluid of inject of pleasant benefit glad can take one place. A lot of new drug still take experiment property, long-dated curative effect is uncertain, but the price is very high, unfavorable recommend try out as medicaments of a gleam of, for example Adefuwei, curative effect is still difficult final conclusion, the price is extremely high, many patients hear curative effect of this kind of medicaments is good, can replace rummy husband to decide, be unable to bear strength then, make hunting drug everywhere, some patients buy medical try out from abroad proper motion, investment is huge, but lack is directive, without scientific basis, the entirely such as the note that uses drug, dosage, period of treatment does not know, the harmful response of the later period that use drug is forecasted hard. Hold proper sex reasonable the proper sex principle that uses drug basically reflects in the following respects: Proper remedy: According to disease and patient airframe condition, balance a variety of advantages and disadvantages element, in choosing congener and optional medicaments, most proper remedy, make the pharmacodynamics effect of medicaments and medical generation kinetic the characteristic can satisfy remedial need, notice the interaction between the correlation between medicaments and airframe and medicaments, make the pharmacodynamics action of medicaments can transform to treat action. For example patient of inchoate liver cirrhosis, liver result is in acting countervail phase, right now choice disease-resistant poison fights liver fiber to change medicaments to be used at the same time jointly, curative effect is best. Proper dosage: Liver of interferon cure second is very general, the assurance of very exquisite dosage, think right dosage of the Chinese is 5 million ~ commonly 6 million unit / second, tertian use, if dose is too small, hard be successful, if dose is too large, medicaments poisonous secondary action is too strong, patient body bears hard. The dosage giving drug with curative proper thing is very important, what must emphasize because of the person different is individual change medical fundamental. Not little now medicaments is the weight according to the patient gives drug, more reasonable. Appropriate time: The medical generation that asks to abide by specific medicaments is kinetic the principle with time pharmacological, it is according to medicaments inside body the rule of action, the design gives medicine time and interval. With assuring hematic drug pH indicator level ground is worth upper limit not the chroma level of prep above occurrence noxiousness, floor level not under effective chroma level. Grow effect interferon to be used every week for example, can ensure chroma of content of Chinese traditional medicine of blood of the patient inside a week maintains basically inside effective limits, can reduce many anguish and trouble to the patient. Proper approach giving drug: Must consider integratedly to use body of property of medical purpose, medicaments, patient state and safe economy, handy wait for an element. Profess to convinced facilitates already to medicine, economy, and the patient suffers drop of painful; vein less to note ought to have mastered get used to disease, do not advocate use easily. Proper patient: Must consider to use case of the physiology state of medical target and disease, distinction is treated. Although average patient, also put in very big difference to the reaction of same medicaments, unfavorable a kind remedial program is carried out at all patients. Remedial second liver emphasizes individual change, because the person applies treated principle, for example interferon treats a target, particular demand illness is in acting countervail phase, transaminase is elevatory, the patient; of duplicate index positive spends second liver virus again or heavy-duty and break take the place of unfavorable use interferon treats the second liver patient of countervail period. Proper period of treatment: According to therapeutic principle, regulate medicationed cycle. Poison of second liver disease-resistant is treated and fighting liver fiber to turn treatment need long-term unremitting, for example husband of try out rummy treats second liver with interferon surely, period of treatment needs to be in 1 year above, when curative effect is apparent, cannot do sth without authorization stops drug, should lengthen cure when necessary, in order to achieve stable and lasting curative effect. But some remedy are unfavorable however and long-term use, avoid to extend medical time, reduce generation save up toxic, virus is able to bear or endure the occurrence of the harmful response such as dependence of property of a medicine, medicaments. For example once second liver patient catchs a cold have a fever, use antibiotic must adopt " short smooth fast " principle, accomplish disease to stop except medicine. Proper remedial goal: Effect a radical cure at present second liver still not actual, but many patient expectation costs are very high, they are being held in the arms not hesitate all cost, also should cure thoroughly the desire of second liver, flounder all directions demands medical service. Medicationed target need is mixed in the person that carry out consensus is reached between the person that accept. The patient often hopes medicine is divided to disease, effect a radical cure thoroughly disease, highbrow perhaps requirement uses the remedy that does not have poisonous side-effect. Both sides of doctors and patients should be adopted mix actively, objectively scientific manner, face up to the current situation, affirmatory both sides can accept, the goal using drug that can achieve below actual condition. The remedial goal that can achieve at present should be to restrain virus to duplicate, defend good liver work, reduce liver to organize fiber to change rate, defer or control an illness to develop to direction of liver cirrhosis, liver cancer. (the exercitation edits: Plum apricot)

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