Hold disease-resistant poisonous opportunity to control second liver illness

Just discovered antigen of surface of hepatitis B virus (the patient of HBSAG) positive, or angst is disturbed, or demoralized, or indifferently inspects, these cannot be taken. Should be being cleared up above all is acute infection. Acute affects 95% above can recover smoothly, need not too anxious. Clinical go up the commonnest is chronic infection, need gives long-term and sufficient attention. Now, we will talk to just discovered how to when second liver virus is affected chronically, should do after all. Distinguishing is " the person that carry chronically " , or " chronic hepatitis B " Xiaowang check-up of 19 years old discovers 　 　 second liver two half-and-half " big 3 this world " already 6 many months, nucleic acid of second liver virus (HBVDNA) ration is as high as 106 copies of 1.2 × / milliliter, there is about a hundred in 1 milliliter blood namely virus of liver of 10 thousand second. But he is not " chronic hepatitis B " , however " the person that carry chronically " , because his liver function is normal, liver vivid check also is changed without apparent inflammation and fiber. The doctor tells Xiaowang, right now virus and human body are in " peaceful coexistence " condition, because this does not need any treatment, but should check regularly. Mr Zhang usually of 28 years old is smokeless wine hobby, but check-up also discovers " big 3 this world " , HBVDNA level is very high. But he is typical " chronic hepatitis B " , is not " the person that carry chronically " , because liver function examination shows its third ammonia is acerbity amino move is enzymatic (ALT) is elevatory, amount to 195 units / litre, b exceeds spot of clew liver area to add thick, add close, liver vivid check shows liver organization has apparent inflammation and fiber to change. The mother of Mr Zhang, HBSAG also is electropositive, because this piece of gentleman is probable,already was affected when be born. The doctor informs Mr Zhang to need to undertake disease-resistant poison is treated, because virus duplicates continuously,be the germ that brings about his liver to damage. And protect liver to fall it is normal that enzymatic medicaments can obtain temporary serum transaminase only, after stopping drug, can have a relapse almost, can serve as the auxiliary cure of chronic hepatitis B only at most, cannot replace the crucial status that disease-resistant poison treats. Grasp good disease-resistant poisonous opportunity, the ideal that strives to obtain poison of disease-resistant of optimal effect 　 to treat gets used to card is: "Big 3 this world " patient HBVDNA 105 copies of ≥ / milliliter, or " small 3 this world " patient HBVDNA 104 copies of ≥ / milliliter, at the same time 2 times normal upper limit is worth ALT ≥ , or organization of indication liver of liver puncture vivid check has apparent necrotic sex inflammation and, or fiber is changed. Short of afore-mentioned standards, but HBVDNA lasts electropositive and ALT relapses unusual, also should consider disease-resistant poison to treat. However, the first time when activity of occurrence hepatitis B, unfavorable haste undertakes disease-resistant poison is treated, should observe 3 ～ first 6 months, have in order to understand keep clear of without the spontaneity immunity that produces second liver virus. The disease-resistant bane substance with the current 　 of disease-resistant poisonous plan that chooses him suit has two kinds, it is common interferon and lasting effect interferon firstly (if get together one 2A) of glycol interferon D, period of treatment makes an appointment with a year of; is rummy husband secondly calm, Adefuwei, for decide than the husband, favour wait for nucleotide for Ka Wei (acerbity) analogue, period of treatment at least two years or longer. Two kinds of medicaments have actor drawback each, answer to be chosen according to getting used to card and individual circumstance. Popularly, to children, teenage patient, appropriate uses interferon first, unfavorable use nucleotide first (acerbity) analogue, lest the influence bears the processing of offspring and virus mutation in the future. Have the woman of birth desire, had better be pregnant after the illness is stable parturient, if need to refuse ill poisonous treatment truly, also answer preferential choose lasting effect interferon, unfavorable choose nucleotide (acerbity) analogue, because its period of treatment is very long, and unidentified to fetal security. To " small 3 this world " patient, rate of recrudesce of common interferon cure is high, appropriate chooses lasting effect interferon or nucleotide (acerbity) analogue. In icteric 10 times normal upper limit is worth ≥ of deep, ALT, when unfavorable use interferon, can choose nucleotide (acerbity) analogue. Use at present get together one 2A of glycol interferon D, can let patient of partial second liver realize HBSAG to turn shade. Consider to discover, appropriate patient uses this drug treatment, the ITBSAG that can achieve 5%.8% turns shade rate. This year is an Olympic Games year, every take part in the match the athlete longs to win gold, although gold can be passed hard by the small number of people only,pick. If: HBSAG turns shade assimilate to wins gold, patient of fraction second liver is striven for through trying hard to mix, it is hopeful win a victory in this one battle that seize gold. Although cannot seize gold, so carry off silver medal or bronze medal also are joyful, the real goal that achieves disease-resistant poison to treat namely then: Restrain virus for a long time to duplicate, make serum HBVDNA and E antigen (1QBEAG) changeover, reduce and prevent the progress that the necrotic fiber that reach liver changes liver cell inflammation, decrease and prevent liver function to break the happening of cirrhosis of acting countervail, liver, liver cancer, prolong life thereby, improve life quality. Know much D: Hepatitis B virus (HBV) for virus of concentrated liver of be addicted to in recent years the progress as a result of technology of cross of nucleic acid element, in cell of the organ outside liver also can check gives HBV-DNA. Through virus of liver of liver of Beijing duck second the experiment considered to offer the evidential person that duplicates in the cell outside liver HBV is likely also duplicate inside the cell outside liver, remain to study deep. . Examination of lens of report of classics of serum of the person that HBV affects has 3 to plant... [detail] (responsibility edits: King sea E)