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Monday, 23 April 2007

Disease-resistant bane content who can gain the championship?

We know, the medicaments of virus of the liver that fight second has two large new force -- interferon and nucleotide (acerbity) analogue. So, what characteristic does content of bane of two kinds of big disease-resistant have? If contrast them, what good qualities and fault do they have again severally? A lot of people do not understand this. Of action mechanism contend for virus of liver of the second inside system of patient of liver of   chronic second to duplicate to be opposite with airframe continuously the iteration of virus immunity is cleared, cause chronic loss to liver. The fight of second liver virus and system of human body immunity formed seesaw battle. Be based on this kind of circumstance, people defies second liver virus has two strategy, it is to let the ability with duplicate virus be restrained, 2 it is to make airframe immunity cleared capability is again a few stronger. ● interferon and nucleotide (acerbity) analogue has the effect that restrains virus to duplicate. ● interferon holds concurrently restrain virus and raise airframe immunity the action of cleared ability. Among them, lasting effect interferon -- get together trade name of glycol interferon A-2a(: Send Luo Xin) the effect is better, it already was supervised by American food medicines and chemical reagents management board (the country such as FDA) , European Union and China and area approval use Yu Yi liver to treat. The nucleotide of ● of the   that contend for   of the advantage (acerbity) analogue controls capacity of second liver virus strong, apply to the patient such as cirrhosis of all sorts of chronic second liver, liver, profess to convinced is convenient. The HBV after cure is duplicate can get inhibition quickly. ● and nucleotide (acerbity) analogue photograph is compared, inside the period of treatment that controls 1 year, via getting together glycol interferon A-2a(sends Luo Xin) cure, the proportion that E antigen change is E antibody is higher (afore-mentioned transition abbreviation are medical admiral E antigen serum changes) , mean a disease to get controlling, antigen of surface of liver of second of the person that minority is treated can disappear even, and young patient use effect is better. Nucleotide of ● of   of   of defect show up one's fault (acerbity) rate of changeover of serum of analogue E antigen is lower, need long-term treatment, stop medical hind to have a relapse easily. Long-term application can happen be able to bear or endure medicine mutates, if rummy husband decides revulsive second liver virus to be able to bear or endure,medical mutation happens early and occurence rate is high, approve use nucleotide recently (acerbity) although analogue reports be able to bear or endure medical occurence rate is low, but still need farther observation. ● interferon needs subcutaneous injection, common interferon a week should inject 3 times, lasting effect interferon gets together glycol interferon A-2a also wants a week to inject. Use interferon side effect is apparent, if appear flu appearance symptom, all round the demote below blood picture, via be treated to disease or stopping medical hind to be able to restore by oneself. The price is higher one of defect that also are this kind of medicaments. Of curative effect contended for   to see the comparison above, so curative effect of which kinds of drug is good? Actually, medicaments curative effect is good depend on medicaments and the person that use is individual circumstance two main factors. ● gets together glycol interferon A-2a(sends Luo Xin) the dominant position is changed in blood of E antigen serum period of treatment of strong, cure is clear, and won't happen bounce stopping drug and be able to bear or endure medicine mutates, it is the good choice that person and young patient treat a disease first. But its price is high, have certain side effect, some patients cannot insist to complete period of treatment, the curative effect that expects with respect to short of in that way. Some patients bear hard, the curative effect that expects with respect to short of in that way. ● nucleotide (acerbity) analogue restrains virus effectively, and take convenient, but remedial time is longer than interferon, emphasize managing treatment. The person that already produced the chronic second liver of liver cirrhosis, be like a nucleotide (acerbity) analogue (if rummy husband is decided) lifelong like hypertensive, diabetic medicaments take, very easy and revulsive virus is able to bear or endure medicine mutates, bring difficulty to follow-up cure. Remedial opportunity and remedial goal are consistent   although two kinds of medicaments exist many difference, but in when can undertake disease-resistant poison is treated () of disease-resistant poisonous opportunity, and when to calculate achieved remedial goal (treat terminal) , these two respects are consistent. ● disease-resistant poisonous opportunity has those transaminase prep above to be worth upper limit 2~10 normally only times, coexist in HBVDNA the talent of a large number of duplicate evidence suits disease-resistant poison to treat. Choose poison of this opportunity disease-resistant, the reason depends on airframe immunity system having to virus " dynamic " the ground revolts, immune system was brought into play adequately to rise, achieve better curative effect with medical general at that time. No matter patient of ● cure terminus accepts the treatment of which kinds of medicine, should detect " second liver two half-and-half " when index, if E antigen disappears, E antibody appears, can regard as achieve clinical admissive treatment is terminal. But achieve remedial terminus and do not mean should stop drug instantly, clinical go up to still can undertake one Duan Gong solid is treated commonly, especially nucleotide (acerbity) analogue, still can do 6~12 commonly of the month consolidate cure. Medical bound is trying two medicine to treat   international and home to trying interferon and nucleotide jointly (acerbity) analogue treats chronic second liver jointly, but whether can heighten curative effect, or have how old rate rises curative effect, still need to have more clinical basises. (the exercitation edits: Plum apricot)

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