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Monday, 23 April 2007

Vigilant: Not by " second liver turns shade " give muddled

Can be chronic hepatitis B effected a radical cure? To adult acute hepatitis B, great majority patient is OK self-healing (it is good to spend period of time like the cold) , final symptom disappears, liver function returns to normal, serum HBsAg disappears, serum HBsAb positive indicates second liver virus is kept clear of, this part person can say to obtain effect a radical cure. However at present socially patient of liver of great majority second is chronic second liver, cure for a long time hard. Actually chronic hepatitis B still is a kind of disease that cannot cure up to now, no matter be home or abroad, no matter be Chinese traditional medicine or Western medicine, still can make chronic hepatitis B complete without a kind of medicines and chemical reagents heal. The reason that chronic second liver cures hard basically has the following kinds: Above all, parasitism of second liver virus is inside the cell, besides liver cell, medullary, bile duct, pancreatic, kidney and lymphocyte are OK parasitism, duplicate, the virus inside the organization is kept clear of not easily, become one of recrudescent matters. Next, HBVDNA and recrudescent relationship are close: The covalence inside liver nucleolus is cricoid close DNA (CccDNA) it is duplicate pattern plate, current and clinical on commonly used interferon and rummy husband all cannot keep clear of surely the CccDNA inside nucleolus, then once out of service fights virus medicaments, the CccDNA inside consist in nucleolus serves as duplicate pattern plate, new transcribe is duplicate. If produce HBVDNA and conformity of body cell DNA, likewise integrated HBVDNA cannot be kept clear of, this also is the reason of a kind of recrudesce. Still have the immune function state that a reason is a patient, immunity is cleared dissident, second liver virus is not the component of airframe oneself, the immune cell of airframe is about to identify, cleared it, but the immune function of patient of liver of most slow second is diseased, be in immunity to be able to bear or endure suffer or immune function is low, cannot develop the function of cleared virus well so. How proper understanding " of second liver turn shade " cure? At present " second liver turns shade " it is to show serum HBeAg or HBVDNA shade turn commonly, HBsAb this world turns (HBeAg turns at the same time companion has back HBsAb appears call " serum is changed " ) . HBeAg, HBVDNA appears in blood virus of reflective second liver is duplicate inside liver cell active, of serum HBeAg, HBVDNA disappear virus of reflective second liver is duplicate tend dormant. If send area of the C before unripe virus,mutate of course, at this moment although blood is medium,HBeAg does not appear, however virus duplicates is active however, detect below this kind of circumstance hematic HBVDNA often is masculine gender. So HBVDNA is virus of reflective second liver is duplicate " golden index " , and the ration that had better undertake HBVDNA detects, conduce to the choice that treats plan and the judgement that combat virus curative effect. Virus duplicates to often be mixed inflammation activity is relevant, disease-resistant poison cure gives to be able to make an illness restore quickly in opportune opportune moment, the inflammation that improves liver organization and necrotic, thereby can the progress of slow down illness, duplicate to a few virus so active and liver has the patient of inflammation to undertake disease-resistant poison treats dispute to often have active sense. But HBeAg, HBVDNA shade turns to meant airframe to already kept clear of thoroughly anything but virus, although blood is medium nonexistent virus, second liver virus still but inside the liver cell of consist in patient, must be clear about at this o'clock. HBVDNA of the blood after use disease-resistant poison is treated shade turns to appear at the same time " serum is changed " these patients compare pure HBVDNA chance of recrudesce of the person that shade turns and HBeAg shade turns is little. As to make HBsAg of serum of patient of chronic hepatitis B turns shade is impossible almost. Emphasize making with all sorts of medicaments blindly second liver virus each index shade turns, with period cure thoroughly, essential short of this kind of curative effect, and because use medicine to be able to accentuate instead in great quantities hepatic burden, bring about liver of sex of patient occurrence medicaments to damage. Disease-resistant poison cure must master strictly get used to disease because   is current poisonous to the disease-resistant of chronic hepatitis B cure still does not have curative effect to reach the remedial method that effects a radical cure completely really, add patient of broad second liver to reach its to treat the current situation not to understand to the basic knowledge of second liver, and they beg the mood with pressing cure, partial medical establishment and businessman seek commercial profit one-sidedly, make the current situation that at present disease-resistant poison treats more confused, the medicaments of all sorts of items emerges in endlessly. More a few all corners of the country swim cure exploit an advantage is hit all sorts of alleged " turn shade " medicine, the patient one disaster after another that this torments to times liver getting second not only, righter limited medical treatment natural resources creates enormous waste. To chronic second the cure of liver should make clear what patient to need disease-resistant poison to treat above all, what patient still does not need disease-resistant poison to treat temporarily. When virus of chronic second liver is affected, virus became much do not appear certainly serious liver is damaged, virus became little not certain also liver is damaged light. Ill to second liver hair mechanism considers to make clear, airframe immunity system is respondent to immunity of generation of second liver virus it is the main factor that causes liver to damage, if behave positive of index of virus of the liver that it is second merely, liver does not have apparent inflammation loss, liver function is normal, we call the person that second liver virus is carried, this kind of patient no matter virus amount how many, at present consensus of the expert on international thinks to be able to be not treated temporarily, need to maintain not good state of mind, abstinence, excessive exhaustion only, do not use caustic liver remedy, every half an year checks liver function and B to exceed to the hospital. Vivid check of liver of travel of the person that if be opposite,second liver virus is carried, discover the person that there is apparent inflammation inside liver, to prevent these patients rapid development is liver cirrhosis and liver cancer, can consider to undertake disease-resistant poison is treated. The patient of chronic second liver that needs treatment basically is to show those liver are damaged apparent, the patient with liver disease rapidder progress, remedial target is to reduce liver cell loss, protect hepatic function, it is normal that the hepatic function that allows a patient is maintained basically, maintain its all one's life not to appear liver function fails. Duplicate to certain virus active, liver damages apparent patient to be able to consider to give disease-resistant poisonous treatment. Cure should be in next professional doctor is directive undertaking that content of   disease-resistant bane has certain undesirable reaction, some patients can appear calorific, have a headache, bald hair, depressed, leucocyte drops, the demote below appetite, among the process that in application so disease-resistant bane content has remedial, must ask to check liver function to the hospital regularly by the doctor, monitor the harmful response of likelihood happening closely, facilitate seasonable discovery and processing, lest cause serious consequence. The patient that uses interferon for example should have the examination of hematic convention regularly, with preventing to appear serious marrow is restrained, 3000 need of WBC < stop medical observation; Use the patient that rummy husband decides for a long time, the second liver virus inside body can produce mutation (YMDD mutates) , this kind of mutation can bring about what second liver virus decides to rummy husband to be able to bear or endure medicine, a few patient returns the wave motion of meeting occurrence illness or accentuation, inchoate discovery the meaning with YMDD conclusive to treating the adjustment of plan to have mutation. The patient that takes Adefuwei should check regularly kidney function. Because some patients fear to go up hospital proper motion seeing a doctor buys drug in drugstore " autonomy " , think can replace the disease-resistant bane matter that taking temporarily, this kind of practice also is wrong. Appeal doctor of specialized subject of hospital of Yu Zheng compasses just is second liver patient those who see a doctor " correct path " , they can understand hepatic situation with all sorts of necessary examinations, be aimed at different illness, different level, use different integrated remedy. See a doctor to still can prevent the disease-resistant bane thing with fake misapplication in office of doctor of normal hospital specialized subject. (the exercitation makes up arrest: Plum apricot)

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