New device: Second liver fights virus circuitry to pursue

Idea of remedial line attempt is increasingly clear 　 last year second half of the year, bring into contact with of doctor of our country part medical group is new academic chronic second liver " disease-resistant poison treats circuit to pursue " concept, but specific how to apply it, still have a lot of doubt. In this session, disease of liver of China cure society learns hospital of friendship of chapter chairman committee member, Beijing Professor Gu Jidong express, from the point of the report of the conference and communication circumstance, this one new idea is more clear, doctor of most cure liverish has begun in clinical lieutenant general it tries to apply; a few long-term curative effect and be able to bear or endure medicine considers to be in progressively development, grow in quantity of optional choose sex. He emphasizes, although at present liver treats second to still cannot achieve the cure, anticipation that suffers from both sides completely the effect, but the progress of this one domain is very rapid. "Disease-resistant poison treats circuit to pursue " main viewpoint is, undertake when chronic second liver treats 12 weeks initiative without evaluate respondently, 24 Zhou Shi evaluates inchoate curative effect, will forecast the result when cure mixes two years one year, whether hold to certainly or adjust original treatment plan. If treat the 24 virus when week to carry a quantity to achieve,detect be restricted (300 copies every milliliter) the following, be treated continuously or the curative effect when two years is better, do not need to if treat the 24 virus when week to carry a quantity to cannot fall,move; of punish cure plan to target level, state existing remedial program is not good, can consider to adjust remedial strategy, if change medicine,perhaps add drug. Of this one new idea put forward, basically be based on for the clinical trial that decides than the husband (GLOBE) data is analysed and already some clinical experience. Professor Gu Jidong says, GLOBE experiment makes clear, according to patient treatment 24 weeks HBVDNA controls rate, but the respondent circumstance that its mix accurate dope 1 year 2 years, can treat know fairly well to sequel not only, be opposite at the same time minority is respondent the patient that owes beautiful (if 24 Zhou Shi DNA still are more than 104 copies every milliliter) can adjust remedial strategy in time, what optimize a patient thereby is individual turn treatment, raise cure to be led successfully. Replace at present be being decided than the husband is the nucleotide analogue that only can offer standardization to consider two years to calculate data. Clinical go up to also be in in succession the test for parallelism that begins other remedy, clinical consult data of this one test applies other nucleotide kind medicationed circumstance is increasing also. Credit of catch a disease of move of China cure society met vice director committee member, southern hospital Professor Hou Jinlin to also express same point of view. He points out, clinical before go up what virus of the liver that fight second treats is respondent the case that appears possibly not completely to add drug or change medicine, now, applied line attempt can make cure more individual change, the virus when treating 24 weeks through detecting carries capacity index to choose next remedial program. The research of poison of disease-resistant of medicine of doctor of traditional Chinese medicine also is make progress somewhat gradually, poison of disease-resistant of doctor of traditional Chinese medicine is treated also is remedial remedial train of thought, differentiate card and the method that differentiate disease combines, treat Gt;gt;gt; of second liver virus through whole of mutiple level, much way " Jun Chenzun makes " liver of cure of doctor of traditional Chinese medicine has therapeutics of follow in a continuous line of advantage 　 order to did not obtain self-identity 　 to go up to current network cure of pair of chronic second liver that circulate " first selection, wait for its to be able to bear or endure other remedy is chosen after medicine appears (cost is higher, the capacity that controls virus to duplicate is stronger) " alleged " foreword as string of 1000 cash (ascend ladder) " therapeutics, all experts in interviewing express to be not agreed with. Professor Hou Jinlin points out, clinical the formulation that go up and does not have this one therapeutics, but the likelihood has a few similar appearances. Refusing ill poisonous treatment need to consider a lot of factors integratedly, if can use the illness variation of the amount of medicaments, fee that uses drug, curative effect and patient,wait. He thinks, apply " circuit pursues " undertaking disease-resistant poison is treated is current commonner and commonner practice, and combine the likelihood that use drug directly more accord with clinical demand (if medicines and chemical reagents is enough cheap word) , "Of course, the large and clinical research that this still needs a standard provides supportive evidence " , he says. Professor Gu Jidong also expresses, curative of second liver virus is fought in the choice when content, just used a few kinds possibly henceforth to have medical science of clear abide card in the begining in cure the medicaments of relevant evidence undertakes associated use, such doing can decrease effectively already be able to bear or endure medical happening, also can enhance curative effect. The application that circuitry of cure of virus of the liver that fight second pursues also trade medicine or combination provided a few reference with medicine. The combination to disease-resistant bane content and Chinese traditional medicine is used, professor Gu Jidong expresses, the clinical research data that did not see standardization at present will support, so bad to be evaluated to this. Nevertheless, he thinks, if the condition is permitted, develop this kind of difficulty that researchs field of nonexistent technology. E antigen changeover is important stop medicine to show the experts that ask for 　 express, clinical go up to be accomplished more easily those who restrain second liver virus is duplicate, reduce level of DNA of second liver virus to be worth to the target namely, but medicine stops to point to in what judgement disease-resistant poison treats when asking for, basically be to see E antigen serological changeover. Hou Jinlin teachs an explanation to say, although level of DNA of second liver virus is reduced detect be restricted the following, the serological changeover; of antigen of occurrence E of not regular also meeting and once appear E antigen is serological changeover, virus DNA level of the patient basically fell target cost is the following. Consider to make clear, interferon of applied lasting effect obtains E antigen the proportion of serological changeover is higher, replace only in nucleotide analogue medicaments can rival to it surely than the husband. Liver ill expert Professor Nicholas of college of medicine of British London university says, application is replaced treat two years surely than the husband, in the remedial crowd that be more than in base line ALT or is equal to upper limit of double normal value, serological changeover rate can be as high as E antigen 36% , 27% what husband of rummy of significance prep above decides, with antigen of the E in interferon serological changeover rate gets together highestly glycol changes lasting effect interferon (α , of 2b) (32%) comparatives. electropositive to E antigen patient, produce E antigen after serological changeover, can insist to use medical 6~8 commonly after the month, can be below the doctor's guidance the consideration stops drug, but total period of treatment must be more than two years, below this kind of circumstance, 50% to the second liver patient of 80% meeting illness is stabilized, if did not produce E antigen,serological changeover cannot stop drug. Will edit next year " guideline " guideline of diagnosis and treatment of standardization of liver of first second of 　 our country -- " guideline of prevention and cure of chronic second liver " (the following abbreviation " guideline " ) came on stage 2005. This one " guideline " roll out, the second liver diagnosis and treatment that is normative our country and job of prevention and cure provided scientific basis and applied reference. Professor Gu Jidong tells a reporter, 2006, ill credit of liver of China cure society is met and affect ill credit to be able to be early or late in 25 cities promotion " guideline " , groomed the doctor; of many 3000 relevant domain this year, they will undertake in more cities and area learning is popularized, the standardization process that liver of second of stimulative our country prevents and cure. Nevertheless, come two this years, in second liver domain of prevention and cure rolled out new pharmaceuticals in succession, achieved results of a few new large and clinical research, formed a few new cure ideas, heightening curative effect, reduce be able to bear or endure medical occurence rate, raised all many sided such as clinical security to produce quite big change. For the research achievement with seasonable understanding, transmission and new application, disease of liver of China cure society learns branch and infection disease learn branch to preparing, begin to edit in next year our country " guideline " . "Look now, first " guideline " virus of the liver that fight second treats the frame sex structure such as basic principle and main train of thought to do not have outdated, editing basically is to do a few local update and enrich. " palpability of watch of Professor Gu Jidong anticipates to this castigatory. (the exercitation makes up arrest: Plum apricot)