Second liver cure wants from " dress warmly and ear one's fill " to " comparatively well-off "

From " dress warmly and ear one's fill " to " comparatively well-off " 　 is told popularly, second liver cure divides roughly for 3 phase: It is above all " dress warmly and ear one's fill " level, through disease-resistant poison cure restrains virus to duplicate, make DNA of virus of liver of the second in blood very low do not detect even, this is the mainest demand. It is next " comparatively well-off " , realize E antigen through cure serological changeover, namely E antigen disappears, e antibody appears. Obtain E antigen serological changeover means a disease to alleviate mostly, human body can restrain second liver virus effectively to duplicate through oneself immunity force, rate of the recrudesce after stopping drug is low. Partial patient can achieve this one goal through fighting virus to treat. The last phase is " rich " , realize exterior antigen changeover, namely exterior antigen disappears, exterior antibody appears. The remedial level that shows level can make the small number of people achieves this goal only. Those who need ambitious shift is, using such argument is to let be not professional personage to understand second liver cure better, understand the difficulty that second liver treats especially. In clinical work, our remedial target still is a basis " guideline of prevention and cure of chronic second liver " will design. "Rich " level is the target that second liver patient longs for day and night, but the nature of exterior antigen turns shade rate has 1 ％ only, use interferon cure can raise 3 ％ one 5 ％ . Regrettablly is, the proportion that these favorite hold in second liver patient is honest too small. Perhaps, to " big 3 this world " the patient, from our more adjacent target, it is to be being solved " dress warmly and ear one's fill " run quickly to on the foundation " comparatively well-off " , 1 antigen is serological changeover. Solve " dress warmly and ear one's fill " it is difficult to do not calculate, if the content of bane of a few kinds of disease-resistant that appears on the market at present is replaced decide than the husband, rummy husband waits surely, what can restrain second liver virus quickly is duplicate, make level of DNA of second liver virus falls to be worth to the target. But, although level of DNA of second liver virus drops check line the following, the serological changeover of antigen of occurrence E of not certain also metropolis. E antigen changeover is those who stop drug is important show bane of disease-resistant of liver of the second that ask for 　 basically includes interferon kind with nucleotide kind. By appear on the market time early or late, nucleotide kind medicaments has rummy husband to decide, Adefuwei, favour replaces Ka Wei, for decide than the husband, powerful effect of poison of disease-resistant of this kind of medicine is rapid, take convenient, undesirable reaction is little. But have a problem cannot evasive, namely nucleotide kind of medicaments be able to bear or endure property of a medicine and long period of treatment. The patient often can ask: Disease-resistant poisonous period of treatment is so long, when be just an end ah 　 　 " big 3 this world " the patient if E antigen has not disappeared stop drug, can have a relapse very quickly; E antigen disappears and E antibody has not arisen, have a relapse likely also; After E antibody arises, recrudescent probability is lesser. When patient of our electropositive to E antigen chronic second liver (namely so called " big 3 this world " ) , use for decide than the husband, rummy husband waits surely after undertaking disease-resistant poison is treated, if remedial result is transaminase ALT returns to normal, DNA does not detect, e antigen appears serological changeover, this is our place hope is respondent. Appear this kind respondent later continue to consolidate again treat a year, if still can continue to maintain this kind is respondent, can consider to stop drug. Say so, e antigen is serological changeover is those who stop drug is important point to proof. Of course, if hepatic foundation is not quite good, have liver cirrhosis for instance, the proposal does not stop drug, because such patient stops drug, rebound to send illness accentuation easily. Objective for, nucleotide kind the biggest question of medicaments needs long-term treatment namely. Although take medicine for a long time to be accepted not easily, but to a lot of patients, what can accomplish at present is stabilize through obtain long-term patient's condition for a long time with medicine. Clinical trial makes clear a whole world recently, application is replaced treat two years surely than the husband. In the remedial crowd that be more than in transaminase or is equal to upper limit of double normal value, serological changeover rate is as high as E antigen 36 ％ , although the 27 ％ O that husband of rummy of remarkable prep above decides is not to be compared directly, but in the patient that can see in these transaminase lifts apparently, serological changeover leads E antigen to comparative with interferon therapeutics roughly. electropositive to E antigen patient, produce E antigen after serological changeover, insist to use drug one year commonly, can consider to stop drug below the doctor's guidance, but still should check to have a relapse possibly with discovering as early as possible regularly. The hepatitis patient as to E antigen negative (namely " small 3 this world " ) , because do not have E antigen changeover, stop medical hind to have a relapse very easily, accordingly, "Small 3 this world " hepatitis patient stops medical time to decide very hard. Abroad thinks to should achieve exterior antigen to turn recently shade ability stops drug, this is opposite actually for most person, cannot stop drug all the time. (responsibility edits: King sea E)