Safety of effect of object height of second liver medicine is crucial

Chronic hepatitis B (liver of second of the following abbreviation) long-term since it is the healthy difficult problem that puzzles the whole world all the time. Chronic second liver needs long-term disease-resistant poison to treat, at present domestic and international " guideline of prevention and cure of chronic second liver " the long-term goal that all thinks chronic second liver treats is: Precautionary liver function breaks acting countervail to; decreases and prevent liver sclerosis and / or the happening of liver cell cancer and lengthen a patient to live time; short-term goal is " double amount to mark " , control DNA of second liver virus the standard that does not detect as far as possible on one hand namely, on one hand serological changeover of antigen of E of implementation of as soon as possible. Up to now, by supervisory management board of national provision medicines and chemical reagents (the nucleotide that SFDA) formal approval uses at treating chronic second liver (acerbity) analogue has include rummy husband to decide, ester, favour replaces Adefuwei block Wei He to replace decide than the husband. Among them, for decide than the husband not only in " double amount to mark " respect more get the better of one prepare, have good security at the same time, it is the remedy of only gravid B class in 4 kinds of afore-mentioned medicaments. For restrain virus action strong 　 to replace what decide than the husband for test and verify surely than the husband " actual strength " , the clinical trial that global liver sick learned man ever began a by a definite date 2 years jointly (namely GLOBE experiments, call 007 research) again, the test is strict according to random, contrast, the principle design of double blind, included to come from patient of liver of 1367 of world each district chronic second. The result shows, compare with rummy husband phasing, for have stronger disease-resistant poisonous result surely than the husband. Take for after deciding 52 weeks than the husband, the DNA of second liver virus of the patient of E antigen positive of 60% has been reduced cannot the level that check gives, and rummy husband decides group of this scale to be only 40% . The clinical trial that has in China subsequently (namely 015 research) , proved to replace the action that decides powerful effect to restrain virus to duplicate than the husband further. The patient is taken respectively for after deciding 52 weeks with rummy husband surely than the husband, detect inside body the scale that is less than DNA of second liver virus is respectively 70% with 43% , difference is likewise notable. E antigen is serological changeover more like getting the better of what prepare 　 and DNA of second liver virus to drop, the patient of chronic second liver with serological electropositive to E antigen changeover has E antigen likewise crucial meaning. Because,this is, once the patient produces E antigen serological changeover, indicating not only virus gets abiding restrain, adumbrative also patient will produce cancer of the liver henceforth or the risk with sclerotic liver is reduced apparently. The research that goes to already confirms, serological changeover produces E antigen earlier, the occurence rate of liver cirrhosis is lower, if patient of chronic second liver can be in 40 years old before changeover of implementation E antigen, the risk that produces liver cirrhosis in the future is only if 2.8%; just appears later in 50 years old E antigen changeover, the patient produces the odds of liver cirrhosis to will lift to 33.3% . GLOBE considers to show, in the patient of E antigen positive, for decide Bilamifu to have taller E antigen shade to turn surely than the husband rate and serum changeover rate. The remedial crowd that recommends in guideline place (level of base line ALT is worth upper limit normally more than the patient of E antigen positive of 2 times) in, take turn for antigen of the E after be being decided than the husband shade rate was achieved 41% , husband of rummy of remarkable prep above decides the 33%; of the group the rate of changeover of E antigen serum of two groups of patients is respectively 36% with 27% . The 015 research that have in China show as a result, turn for the E antigen after deciding group patient to take drug 2 years than the husband shade rate and serological changeover rate all husband of rummy of apparent prep above is decided group, it is 40% pairs respectively 28% and 29% pairs 20% . For have good security surely than the husband 　 besides in " double amount to mark " the respect has good performance besides, for also have clear advantage in security aspect surely than the husband. For the security before what decide than the husband is clinical research shows for do not have the genetic noxiousness, sex that cause cancer and reproductive noxiousness surely than the husband. In nucleotide (acerbity) in analogue, replace only be labelled by American FDA surely than the husband gravid B kind medicaments, and rummy husband is decided, ester of A Defu Wei and favour all attribute gravid C level for the medicaments such as Ka Wei. In newest 2008 Asia-Pacific area " chronic hepatitis B runs a guide " in point out clearly " if the woman of content of bane of disease-resistant of profess to convinced happens,be pregnant, can continue to use gravid B kind medicaments " . And clinical the applied experience that go up also proves, for the medicaments that be being decided than the husband is a kind of safety. GLOBE considers to show, decide group likeness for the occurence rate that decides group of undesirable incident than the husband and rummy husband. Occurence rate is affected for the upper respiratory tract in the undesirable incident of 5% above, have a headache, kinase of phosphoric acid of fatigue, nose pharyngitis, blood (CK) is elevatory, on bellyacke, diarrhoea, disgusting wait with dizziness. When treating 52 weeks, replace than the husband calm group happens 3, the rate with 4 class elevatory ALT is 4% , calm group is rummy husband 8% . 3, the occurence rate with 4 class elevatory CK, for than the husband calm treatment group is 9% , rummy husband decides remedial form for 3% . And the patient with great majority elevatory CK does not have a symptom, follow the next time in what continue to treat when visitting, can reduce apparently normally. CK lifts is nucleotide (acerbity) analogue is treating the common phenomenon in slow second liver, different clinical research shows rummy husband is decided as a result, ester of A Defu Wei and the story that for the choose a site for the capital that compare a husband CK lifts. About CK elevatory meaning remains to discuss further. Altogether, for regard a kind of new-style nucleus saccharide as disease-resistant bane content surely than the husband, clinical before the security that reached clinical research to all confirm it is good, show the advantage that comparative. ▲ liver has ailmenting hunger to cause! Liver protects to come after third liver sends the 3 old dangerous wine of cancer of the liver bowl hot noodles in soup walks out of error recognize small 3 this world encounter Oriental liver when western liver " liver " ask: Is the road in He Fang? Chinese traditional medicine hurts liver word you know! 18 action prevent hepatic grow stout! What natural food can protect liver? Second liver cure wants to understand more liverish in 　 of ceaseless progress 　 relevant knowledge, click Nbsp; of Gt;gt;gt;gt; liver ill channel please (the exercitation edits: Plum apricot)