Liver cure is in second to progress ceaselessly

1963: The antigen of Australia of Aa(of antigen sex material that Baruch Blumberg and Harvey Alter discover in Australian native blood first) (hind change weigh HBsAg, namely) of antigen of hepatitis B surface. Since discovery since second liver virus, medical worker had not stopped the make a stand against with second liver virus, experienced among them countless failure and but, come till nearly 10 years people just discovers a few medicaments that can restrain second liver virus effectively to duplicate gradually. Let us review the changes of the content in coming to our country nearly 30 years concern plan of hepatitis B prevention and cure here, can experience the tremendous progress that treats a field to chronic second liver deeplier. Come nearly 30 years, china medicine can hold ill annual meeting of countrywide contagion, liver for many times, invite expert of countrywide contagion, liverish to discuss virus sex hepatitis (include second liver) diagnose and treat, be in early or late 1979, 1984, 1990, mixed 1995 released property of 5 edition guideline 2000 " plan of prevention and cure of virus sex hepatitis " (abbreviation: " plan " ) . 1979 the first edition " plan " when coming on stage, already had antigen of second liver virus detect method, but of antigen of armour hepatitis virus and antibody detect the method still cannot apply extensively, third hepatitis virus has not discover. Accordingly, " plan " the clinical branch that treats a part to be able to press virus sex hepatitis only put forward: Hepatitis of chronic defer sex basically is Western medicine is mixed combine traditional Chinese and Western medicine the cure that protect liver, hepatitis of chronic activity sex and outside weighing disease hepatitis to divide the cure that protect liver, still mentioned use cortin to treat. The doctor of traditional Chinese medicine that plan still treated virus sex hepatitis with more space is adj cure, this shows lacks cure at that time the chemical remedy with chronic effective hepatitis (Western medicine) . But, passed 5 years merely, experts realise the cortin treats chronic hepatitis disadvantages outweighting the advantages. 1984 edition " plan " put forward: Hepatitis of chronic defer sex " can choose Western medicine, Chinese traditional medicine, or combine traditional Chinese and Western medicine " the cure that protect liver, do not advocate hepatitis of pair of chronic activity sex and patient of serious illness hepatitis to use cortin treatment, the hepatitis of chronic activity sex that has pair of HBsAg(-) only, person that oneself immunity is behaved just can use cortin treatment. Be in " plan " in, what experts realise the past ignored pair of virus sex hepatitis to treat is random contrast observation, "The long-term curative effect of a lot of medicaments cannot affirm " . 20 centuries 80 time, it is cause of disease of virus sex hepatitis learn to consider " big bumper harvest " time, discovered virus of third hepatitis virus, man hepatitis virus and the fifth of the ten Heavenly Stem hepatitis early or late, but remedial respect is without progress however. Accordingly, 1990 edition " plan " cure is told rarely partly, carried principle of a few cure only, cortin therapeutics already from " plan " in disappear. Although domestic and international scientist tries to use immune conditioning agent or A candy adenosine after Ceng Xian,wait for generation nucleotide kind medication second liver, but all because of curative effect unsure or side effect is too big wait for a reason to end in failure. Because lack effective curative substance, this one edition " plan " can afterwards hopes the traditional medicine at our country, emphasize a doctor of traditional Chinese medicine adj cure. 1986, people used gene project method to realize the big batch of interferon to produce. Since 1991, interferon begins to be used at treating second model with third hepatitis. This one progress makes the cure of chronic second liver showed first sight of morning of a gleam of. 1995 the 4th edition " plan " first will 5 model the cure of virus sex hepatitis is discussed respectively, put forward disease-resistant poison to treat first in the cure of chronic second liver. But because a lot of cure are done not have at that time very good " contrast randomly observation " research, interferon cure is in clinical on applied time is shorter, experience is not sufficient still, accordingly, grown of 7 pages " plan " in remedial treatise takes half page only, be less than 600 words. Although mention disease-resistant poison to treat, but did not mention specific medicaments and remedial method. The content that the doctor of traditional Chinese medicine treats also was cancelled, what visible doctors treat to chronic second liver is helpless. After 1995, people treated respect of chronic second liver to accumulate more experience in interferon, discovered a kind of new nucleotide again at the same time kind medicaments -- rummy husband has good inhibition to second liver virus surely, the clinical research that is as long as 5 years had to it inside limits all over the world. Accordingly, 2000 the 5th edition " plan " in put forward above all: The main reason that second liver changes chronically is " affect continuously as a result of virus " , "Should take disease-resistant poison seriously to treat to chronic hepatitis " . "The purpose that refuses ill poisonous treatment is: ① restrains virus to duplicate, reduce contagious; ② to improve ③ of liver function; to reduce liver to organize ④ of pathological changes; to raise life quality; to ⑤ decreases or prevent liver the happening of sclerosis and cancer of cell of liver of former hair sex. " in " plan " detailed explain understands interferon α to treat medium application in chronic second liver in accessory, was sure rummy husband decides the inhibition of pair of second liver virus. Can say, rummy husband is nucleotide surely kind medication a milepost of chronic second liver, it is little, OK that it has action of virus of the liver that fight second is strong and rapid, undesirable reaction profess to convinced, use convenient wait for an advantage. But, as clinical and wide application, new issue appeared very quickly again. After people uses rummy husband to be treated surely 1 year, the second liver virus inside system of a few patients produced mutation, appear be able to bear or endure medicine, second liver virus new activity rises, make liver disease of the patient accentuates again. Then, people intensifies studying new curative other people, like hoping to be able to resemble antibacterial content, a kind of medicaments is able to bear or endure medicine, again more medicaments are replaced, achieve the goal that restrains second liver virus for a long time thereby. Below the scientist's effort, lasting effect interferon appeared on the market, more nucleotide kind new drug of virus of the liver that fight second considers to come out. On this foundation, the cure of ill expert of Asia-Pacific area liver to second liver reached consensus 2004. In " Asia-Pacific area is chronic hepatitis B handles consensus " (abbreviation: " consensus " ) in, experts affirmed the curative effect of poison of second liver disease-resistant, put forward to control the remedial target of second liver virus for a long time, the remedial plan that made husband of interferon, lasting effect interferon, rummy decide. Be in " consensus " in, experts still are mentioned " traditional Chinese traditional medicine, the likelihood has remedial effect, but need test and verify. " 　 　 after 2004, more nucleotide kind medicaments of virus of the liver that fight second appears on the market or enter clinical trial. Be in our country, adefuwei, favour replaces calorie of Wei He part surely than the husband 2004, mixed 2005 appeared on the market 2007, still have more than 10 kinds of remedy that studying. These progress are more sturdy the determination that doctors fight second liver virus. Accordingly, in December 2005, disease of liver of China cure society learns branch / China medicine can affect ill credit to be able to combine formulate our country the first " guideline of prevention and cure of chronic hepatitis B " , the overall objective that offerred treatment of chronic second liver is: "Utmost ground is restrained for a long time or eliminate HBV, relieve liver cell inflammation the necrotic fiber that reach liver is changed, defer and prevent a disease to make progress. " " it is crucial that disease-resistant poison is treated, should have only get used to card, and the condition allows, should undertake normative disease-resistant poison is treated. " this one formulation is compared before " plan " and " consensus " had apparent progress, become clinician make a diagnosis and give treatment the important basis of chronic second liver and standard. Second liver is one of contagion with our country higher incidence of a disease, the medical worker is trying hard to study updated remedy. But all medicaments have his to get used to card, especially a few new drug, cure should fall in the doctor's guidance, prevent abuse, monitor regularly, reduce harmful response, ability achieves his optimal curative effect. (the exercitation edits: Plum apricot)