Why doesn't have an inoculation of second liver vaccine have antibody?

Antibody (fight, HBs) turns for masculine gender. But. Via often can appearing this plants circumstance: When vaccine presses a regulation, planted 3 times secondhand, but second liver virus checks after a few months 5 index (common calls two half-and-half) , vaccinal effect as like a clay ox entering the sea-never to be heard of again into thin air -- antibody of second liver surface does not arise from beginning to end. For this, many people feel doubt and fear -- do not hit vaccine to be no good, hit vaccine to do not have reaction again. Nowhere is not in virus of liver of the second in the life, little " ballproof garment " , those who face second liver virus " a heil of bullets " be about await one's doom? The matter that antibody does not produce after inject is vaccinal is more complex, have the following kinds of cases probably: Nbsp; 　 detects the method is not accurate and effective already produced antibody, but because detect the method is not accurate and send result negative. Ought to use the most acute method at this moment, if law of enzymatic couplet immunity or radiative immunity law come,detect afresh. Because some places detect not advanced or the method is not acute and reach false negative result. Immunity reacts too weak airframe reacts to vaccinal immunity too weak, produce the antibody of minim only, down to is used detect advancedly the trace that the method still fails to discover exterior antibody. The dosage that can increase second liver vaccine at this moment (every time 10 microgramme) , inject every months 1 times, in all 3. In the meantime, vaccine of inject second liver is operable and other immunity stimulates medicaments, wait like polysaccharide of umbellate pore fungus, BCG vaccine, be thought to be able to improve immune result. Already happened exterior antibody still does not produce after hiding sex appeal to if press formulary time have an inoculation,be caught, criterion enlarge of the nucleic acid outside applicable PCR(body adds a skill) the method detects by have an inoculation person the nucleic acid of second liver virus in serum (HBV, DNA) . Because, a few patient already contracted second liver virus actually, antigen of surface of Dan Jiyi liver (the crop of HBsAg) is very few, detect with what have the method is checked do not come out, or second liver virus has produced mutation, do not produce reaction with common reagent, have other reason possibly still additionally. Although these patients already contracted second liver virus, but do not produce immunity to react and airframe shows immunity to be able to bear or endure accept position, below this kind of circumstance, inject again second liver is vaccinal, also won't produce exterior antibody. May detect content of mark of other liver virus, like core antibody (fight antigen of antibody of HBc) , E, E to wait to whether be masculine gender. If was specification of masculine gender criterion to contract virus, below this kind of circumstance, inject again second liver vaccine won't arise possibly also fight, HBs. Liver having second is familial history or the person that often contacts with second liver patient, should the vaccinal effect of vaccine of liver of special attention second. The probability of virus of liver of second of infection of member of second liver family is extremely high, after a few members contract second liver virus, to reveal hide condition. The children with strange place of second liver patient, must inject in time after be born second liver is vaccinal, so OK the transmission that block stops virus of major second liver. But, even if is vaccine of liver of seasonable inject second, still can have few number new life immune have an inoculation fails, virus of liver of second of the infection inside this likelihood and palace of pregnancy of the mother's body and genetic element are concerned. To this the parent need not make a fuss of, the not random also; that use drug checks regularly, notice liver function change is crucial. Immune function blemish of low, immunity person the person that has similar case produces antibody not easily, the person that like terminal nephrosis, organ transplanting hind, AIDS is affected. Second liver virus is incidental mutation, the virus after mutation, its biology character had new change, can make second liver vaccine cannot produce effect. Additional, the person that virus of liver of a few second is affected, of antigen of surface of second liver virus inferior model differ somewhat. Inferior model sort has a variety of, second liver vaccine is to be aimed at main virus inferior model and set, so hard to avoid has attend to to be less than inferior model, if be relatively rare virus inferior model, second liver vaccine also won't have protective effect. Anyhow, hit the person that second liver vaccine does not produce antibody, if still do not produce antibody,can add; of dozen of a period of treatment, should notice to eliminate to whether be the person that hide gender or infection of virus of low-level second liver, and whether to put in circumstance of mutation of second liver virus. The following check the job must be in the normal hospital with higher level to undertake (the exercitation edits: Plum apricot)