Sunday, 18 March 2007
Do we want pursuit of one be ignorant of to turn shade?
A wrong tendency that treats second liver at present is seek target of second liver virus blindly turn shade, once turn,be like index of virus of second liver patient shade, with respect to everything is just fine, actually otherwise. Index of second liver virus turns back backside, still put in a series of problems, may not of virus index change is meddlesome. In clinical often discover such a few phenomena, some patients are cost countless, can turn for virus index shade, treat will be treated, also always do not turn shade; Although some patient virus index turn shade, but the illness is exasperate however. The real cause that second liver treats is: Safeguard and maintain normal liver function, poison of disease-resistant of proper and correct inflict and fight fiber to turn treatment, maintain good state of mind, hold normal life and working position. The key that why treats second liver is turning at virus index shade? Need turns the virus index of shade is very much, all turns shade is far from likely the need that at present assay can obtain turns the index of second liver virus of shade includes: Before virus of liver of IgM of antibody of core of virus of liver of antigen of antigen of antigen of surface of second liver virus, E of second liver virus, core of second liver virus, second, second - before virus of liver of S1 antigen, second - DNA of virus of liver of S2 antigen, second is waited a moment. Because these virus index have its distinctive clinical sense, treating an end is not a requirement among them 9 index turn shade, ask all index all turns however shade, but do not have so all-purpose medicaments at all at present. Best now disease-resistant bane content, for example husband of interferon, rummy is decided, bitter ginseng element is waited a moment, use in optimal opportunity, the second liver patient that also can make 40 % are controlled only appears DNA of second liver virus turns antigen of E of virus of liver of shade, second turns shade, of exterior antigen turn shade rate has not exceeded 10 % . Specific virus index turns shade may not is meddlesome what make a person feel bemused most now is, the virus index that expended an innumerable trials and hardships to be changed turns shade, may not is meddlesome, may not is the symbol that second liver changes to good way. Contrary, certain virus index turns shade, it is the result that second liver virus mutates likely, the second liver virus after mutation may bring about more serious consequence. Clinical go up to often see a few patients, through long-term remedy, second liver " big 3 this world " turn eventually for " small 3 this world " , however this kind of change often brings about illness aggravation. Thought all the time in the past, second liver " big 3 this world " turn for " small 3 this world " it is illness incline to alleviate and even the mark of natural heal. Discover now, liver damages the patient that this kind of change restricts half the number to still exist and develop continuously, as a result of,this is before second liver virus - C/C area produces mutation be caused by, the commonnest choppy form is 1898 or companion has 1901 mutation, the likelihood after mutation makes individual plant of mutation of second liver virus escapes host immunity is surveillant, and be able to continue to live to multiply and can lead to serious consequence. Exsanguinate assay mirrors the quota of second liver virus with current of hepatic and internal actual state of affairs hard is to pass exsanguinate assay gain, the virus in can mirrorring blood only is kept clear of or low-key degree, the actual condition that can be not represented completely or reflects a hepatic interior. Pass haemal inspection, reflective circumstance may be false appearance, the virus index form in blood is varied, change not is measured, index of any a kind of virus appear possibly with mutation form deviation, exsanguinate assay just understands hepatic situation from a flank, the authenticity of the result and dependability far not as good as the first-hand data that liver histology examination obtains. Especially partial patient, through cure, not only " big 3 this world " turn for " small 3 this world " , then antigen of surface of second liver virus also turns shade, this should be the ideal outcome that doctor and patient long for day and night. But, the patient's illness not only did not improve, appeared to worsen instead, many liver cirrhosis are terminal patient, even patient of partial liver cancer, assay examination discovers antigen of surface of second liver virus, E antigen is electronegative, only core antibody is masculine gender, the cadaver check that after these patients die, has, the DNA of second liver virus of duplicate condition still discovered in liver organization. Check index of second liver virus through exsanguinate it is thus clear that not complete and reliable. Although,itself of index of second liver virus is not invariable need not any medicationing, virus index also should produce change. Index of second liver virus is Protean, the possibility produces positive change as a result of medicaments action, it is possible also under the pressure of medicaments, produce inactive and harmful mutation. Turn through observing norm of second liver virus merely it is one-sided that shade will judge curative effect stand or fall. Change of index of second liver virus is inevitable trend, no matter cure uses drug, virus index happens possibly such or in that way change. According to second liver virus the biology cycle inside human body is mixed metabolic characteristic, virus is met as the change of patient age and airframe immunity function change. With respect to nature of antigen of surface of second liver virus cleared circumstance looks, there is not the person that keep clear of naturally almost 20 years old before, 40 years old of nature turn shade exceeds 1. 5 % , 55 years old of above person more than 3 % . In the person that our country Taiwan saves poison of second liver ill to carry, serum E antigen (big 3 this world) positive rate is as high as 74 when 10 years old. 7 % , after this decreases as the addition of the age, decrease when 20 ~ is 40 years old to 42 % , 50 years old of above person fall to be controlled to 20 % , of 70 years old of above " big 3 this world " the patient is infrequent. Recently, the report such as American McMahon, the person that virus of liver of chronic to 1536 second is carried undertakes 1 ~ 34 years (average 12. 3 years) follow for a long time visit, the result shows antigen of E of virus of liver of the second inside 10 years turns shade rate is as high as 72. 5 % . These consider to make clear, the nature that index of second liver virus can produce a variety of situations turns shade, although need not one medications, virus index disappears likely also, of these virus index turn shade, must adj distinction is treated, cannot see index turns shade glad, still need to differentiate virus to turn shade is true patient's condition alleviates, still be the false appearance that virus mutation brings. Liver of second of basic knowledge is initiative turn the person that shade leads liver of not low second to take poison, the HBsAg of the person that HBsAg of sex of special dispute activity is carried is initiative turn shade rate is very high, this is Taiwan province scholar recently report. Alleged and initiative turn shade, namely need not any medicationing, the immune function that relies on him airframe kept clear of HBsAg. Doctors noticed this kind of phenomenon early, but think all the time initiative turn shade rate is very low. Taiwan saves scholastic report to point out, the person that the high popular area in second liver is carried without semiotic HBsAg has taller initiative HBsAg is cleared rate. Report according to them, observe 10 years initiative and cleared rate is HBsAg 8. 1% , observation is 20 years 24. 9% , observation is 25 years 44. 7% , and of 79% initiative and cleared after happening in 40 years old. That is to say, the person that the second liver of 40 years old of above is carried will have an in part initiative and can cleared HBsAg. The hair sick condition of the person that somebody returns special care to be carried without semiotic HBsAg, namely whether become hepatitis. Observation is informed, will have 21 20 years. 5% come on, the end carries state, have 1 every year about. The incidence of a disease of 55% , but the person that these coming on still can appear 20 years later in 3 ~ of HBsAg initiative and cleared, and the person of initiative and cleared HBsAg won't come on again. Since our country mainland begins immunity of second liver vaccine oneself, the HBsAg in the crowd is carried rate is apparent already drop, but still having 93 million person is the person that take poison, their hepatic function is basic it is normal, because this author thinks,do not need disease-resistant poison to treat mostly. (responsibility edits: Zhang Jiong smooth)
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