" of protracted battle of second liver " should be held out

Nbsp;nbsp;nbsp; although the core that poison of second liver disease-resistant is treated is remedial second liver and essence, but still lack specific substance at present, all sorts of existing medicaments, can remove effective inhibition only virus action, once stop drug, virus is duplicate likely once more active, the illness has a relapse, because this fights ill poisonous cure to need to undertake for long, prop up long-term remedy to need to spend much money, at present these fight virus medicaments price not to poor, use for a long time can let a patient assume pressure of economy of a huge sum, should have done each preparation to work before disease-resistant poison is treated so, choose to suiting it is disease, good to do along with all sorts of accidents in seeking course of good treatment of the job, processing, ensure cure goes on wheels. Additional, positive research and development gives the way that better good in quality and cheap in price medicaments just is prospective effort. At present our country is using medicaments of virus of the liver that fight second to include interferon kind with nucleotide (acerbity) analogue, two kinds of big medicaments have its actor drawback each. Former advantage is period of treatment is secured relatively, serological changeover leads antigen of E of second liver virus and E antibody taller, curative effect is relatively lasting, be able to bear or endure medical variation is less, its defect is to need inject to give drug, harmful response is more apparent, unwell the person that break acting countervail at liver function. Latter good point is profess to convinced gives drug, control virus function strong, undesirable reaction is little and slight, can use at the person that liver function breaks acting countervail, its defect is period of treatment is not secured relatively, serological changeover leads antigen of E of second liver virus and E antibody low, curative effect is not quite lasting, long-term application can arise be able to bear or endure medicine mutates, illness aggravation can appear after stopping drug. Disease-resistant poison treats the time with long need: Our country " guideline of prevention and cure of chronic hepatitis B " the period of treatment that stipulates poison of disease-resistant of every kinds of medicaments treats need is respectively: 1, common interferon 5 1 million units (but according to the patient be able to bear or endure suffer a circumstance to adjust dosage appropriately) , every week 3 or tertian 1, hypodermic or the inject inside muscle, primary period of treatment is 6 months. Lasting effect interferon includes to send Luo Xin (get together glycol interferon α - 2a) He Peile can (get together glycol interferon α - 2b) two kinds, dosage can be mixed according to patient weight be able to bear or endure to get a case and be decided, every week 1, hypodermic, period of treatment 1 year, if have respondent (effective) , come 1 year to raise curative effect to also can lengthen period of treatment or longer. If stop the curative effect when medicine good, but after spending period of time, virus index turns again in relief, the illness has a relapse, still can enable interferon again. Reflect this analysis, think second liver patient undertakes interferon is treated for many times likely. 2, nucleotide (acerbity) analogue includes: Rummy husband is decided (100mg, daily 1 profess to convinced) , ester of A Defu Wei (10mg, daily 1 profess to convinced) , favour for Ka Wei (0. 5mg, be able to bear or endure surely to rummy husband medical patient is 1mg, daily 1 profess to convinced) and for decide than the husband (600mg, daily 1 profess to convinced) , above 4 kinds of medicaments, primary period of treatment is 1 year, antigen of E of virus of remedial second liver is electropositive (" big 3 this world " ) patient when 1 year, if assay checks DNA of second liver virus not to detect,arrive or under detect floor level, liver meritorious service is regular, antigen of E of second liver virus turns shade but did not appear E antibody person, the proposal continues to use drug, till E antibody appears, via be being monitored 2 times (every time at least removed 6 months) , the person that still keep changeless can stop drug, after stopping drug, need to monitor hepatic unripe chemistry and virus closely to learn index. If use these 4 kinds to medication antigen of E of virus of liver of second of second liver virus is electronegative (" small 3 this world " ) patient, remedial target should achieve DNA of second liver virus to turn not only shade, liver meritorious service is regular, achieve antigen of surface of second liver virus even (" bay fight " ) turn shade, this will mean whole cure to must last old. Use these 4 kinds to medication patient of cirrhosis of second liver liver, whole cure is lifelong sex. Can see disease-resistant poison is treated will be a be worthy of the name from this " protracted battle " . The medicaments cost that additionally poison of second liver disease-resistant treats is quite high, for can the expenditure that poison of disease-resistant of liver of second of more clear report treats, try to elaborate and explain with form of the following form especially: One, common interferon, include the 　 of a few breed such as element of heart of Sai Rejin, carry, Yintefen, Anfulong to get used to disease: Chronic second liver, DNA of second liver virus is electropositive person, liver cirrhosis breaks acting countervail patient to ban dosage of the usage that use 　 : The inject that lie between a day 1, 　 of a 5 million unit time of a period of treatment: 0. 5 ～ price of 1 year of 　 : Every 50 ～ a period of treatment predicts 80 yuan of 　 charge: 9000 ～ remarks of 12000 yuan of 　 : Breed is more, cent is α - 2a and α - 2b, it is homebred 　 more 2, lasting effect interferon, include: Clique collect glad (get together glycol interferon α - 2a) He Peile can (get together glycol interferon α - 2b) 　 gets used to disease: Chronic second liver, DNA of second liver virus is electropositive person, liver cirrhosis breaks acting countervail patient to ban dosage of the usage that use 　 : Inject every week a 　 time of a period of treatment: 0. 5 ～ price of 1 year of 　 : Every 1000 ～ 1500 yuan of 　 period of treatment predicts cost: 50000 ～ remarks of 70000 yuan of 　 : Lasting effect interferon has a variety of different dosage norms, all be entrance 　 3, rummy husband decides (He Puding) 　 gets used to disease: Chronic second liver, DNA of second liver virus is electropositive person, liver cirrhosis patient also can use 　 usage dosage: Everyday a 　 of every 100 milligram time of a period of treatment: At least 2 ～ 2. Price of 5 years of 　 : Every a period of treatment predicts 17 yuan of or so 　 charge: 6000 yuan control 　 remarks: Mutation is able to bear or endure medical rate is higher, once be able to bear or endure to medicine needs to combine Adefuwei and use 　 4, for decide than the husband (element compares volt) 　 gets used to disease: Chronic second liver, DNA of second liver virus is electropositive person, liver cirrhosis patient also can use 　 usage dosage: Everyday a 　 of every 600 milligram time of a period of treatment: At least 2 ～ 2. Price of 5 years of 　 : Every a period of treatment predicts 24 yuan of or so 　 charge: 8600 yuan control 　 remarks: Mutation is able to bear or endure medicine leads taller 　 5, Adefuwei (He Wei force, Dai Ding, name, A Dixian, long He Ding of happy, A Gan Ding, actor) 　 suits: Chronic second liver, DNA of second liver virus is electropositive person, liver cirrhosis patient also can use 　 usage dosage: Everyday a 　 of every 10 milligram time of a period of treatment: At least 2 ～ 2. Price of 5 years of 　 : Every 11 ～ control 　 20 yuan a period of treatment predicts cost: 4000 ～ control 　 remarks 8000 yuan: Have homebred with the entrance many breed, the price each different 　 6, favour for Ka Wei (rich road decides) 　 gets used to disease: Chronic second liver, DNA of second liver virus is electropositive person, liver cirrhosis patient also can use 　 usage dosage: Everyday a 　 of every 500 microgramme time of a period of treatment: At least 2 ～ 2. Price of 5 years of 　 : Every a period of treatment predicts 38 yuan of or so 　 charge: 13000 yuan control 　 remarks: When treating the person that rummy husband mutates surely, need takes price of each district of content of bane of disease-resistant of liver of 2 　 second to have difference a bit everyday, great majority is not protected in cure submit an expense account, when this means patient of broad second liver to decide to undertake disease-resistant poison is treated, must mature to oneself economic actual strength is mixed bear ability, 10 thousand cannot pursue temporarily fast only, rushed and brash mount a horse, hold to feebly in the future. Disease-resistant poison treats need to hold to for a long time, cannot quit casually, stop medicine suddenly to cause an illness to accentuate likely, especially nucleotide analogue. Common interferon is used at treating chronic hepatitis B to already had old, curative effect is inferior to growing effect interferon (get together glycol interferon) but the undesirable reaction of two kinds of medicaments is similar, the patient wants to be faced with and overcome in whole cure process: Marrow is restrained, the worry of a variety of harmful response such as calorific, lose one's hair. Patient of most and chronic hepatitis B can treat ability to realize lasting virus to restrain through long-term nucleotide analogue only, because want to achieve ideal remedial result: DNA of second liver virus lasts shade turns, antigen of E of second liver virus and E antibody produce serological changeover, liver result keeps normal from beginning to end, this can be not achieved quite inside short time; Use nucleotide analogue treats patient of cirrhosis of second liver liver, need is lifelong take drug; Patient of negative of antigen of E of virus of remedial second liver needs to treat antigen of surface of second liver virus to turn till shade. Use nucleotide analogue fights virus to treat, cause mutation of second liver virus to be able to bear or endure likely medical case happens, once produce need to change remedial plan, after changing, it is better to no matter combine,convert medication, the increase that means remedial cost, all these decides disease-resistant poison is treated will be one " protracted battle " and " spend war " , doctor and patient need discreet decision, and be in process of cure of whole disease-resistant poison follow regularly visit, close observation, in case accident. (responsibility edits: Zhang Jiong smooth)