Recently: Fight the development of type of HBV medicaments occurrence explosion

In the United States and whole world, chronic HBV infection is the main reason that causes liver cirrhosis and liver cell cancer. Cleared infection and precaution affect the double cause that complication is cure chronically. Before 90 time metaphase, optional treats medicaments interferon of be confined to a kind. And recently 5 years, fight the development of type of HBV medicaments occurrence explosion. α interferon and rummy husband are two kinds of remedy that are used at treating chronic HBV to affect permissibly at present surely. Interferon has disease-resistant poison and immunity to adjust two sides effect. Applied interferon 5MU is daily 1 or 10MU1 week can make antigen of 20% host HBVe disappears 3 times, antigen of surface of 6% host HBV disappears, and in curative effect of most case of illness abiding. Rummy husband is the drug of profess to convinced that is used exclusively at treating chronic HBV to affect permissibly at present surely. It can participate in HBVDNA synthesis with DCTP competition, conformity hind stops virus DNA synthesis. Analogue of nucleotide of certain to oxigenate, the main mechanism that the Wei of the name of a river in Shaanxi and Henan provinces of extensive former times that includes to be in phase of different and clinical research, Entecavir, Emtricitabine reachs Adefovirdipivoxil to wait is get together more with HBV enzymatic natural base thing competes, stop the synthesis of virus DNA catenary. The closest report has two kinds to fight HBV drug newly: N- Ren base, element of mildew of deoxidization wild Kao (Ren radical of DNJ) and N- , deoxidization element of mildew of half lactose wild Kao (DGJ) . N- Ren base, DNJ is butyl of a kind of N- , the ramification of DNJ. In enzymatic depressor of Pu candy glucoside N- butyl, below the action of DNJ, virus candy albumen can produce wrong fold, HBVDNA is inside the cell save up, HBV is released decrease. N- Ren base, DGJ is not enzymatic depressor of Pu candy glucoside, but have however stronger combat HBV curative effect. N- Ren falls with chroma in place base, Ren radical of DNJ and N- , DGJ can make HBVDNA synthesis reduces 8/9 and 14/15 respectively. Its disease-resistant poison is active second Yulamifu is decided, but comparative with other nucleotide analogue. Notable is them enzymatic active of glucoside of noninterference Pu candy, also do not have cellular noxiousness. The likelihood is to pass mec housing of clothing of RNA of group of the gene before interference to form, quicken degradation of virus core grain, changeover of RNA of group of the gene before the influence is recorded and produce effect. In addition, they can restrain the interaction between virus core albumen and the distinctive cell gene that cause nucleoprotein to the mistake is assembled and be stabilized. As fight HBV drug newly, n- Ren base, Ren radical of DNJ and N- , DGJ action mechanism is distinctive, made up for the inadequacy of nucleotide analogue action, and the defect that does not have nucleotide analogue, if disturb nucleic acid synthesis, noxiousness of line bead body. As fight HBV medicaments newly to be in clinical applying ceaselessly, to chronic HBV infection has the possibility associated cure. But for HBV cure devises optimal combination plan, should absorb effect of activation mechanism, medicaments considering medicaments efficiency, medicaments dot, right CccDNA influence reachs long-term remedy and pose the problem such as distinctive virus mutation. When devising plan, the distinctive virus mutation related to every kinds of medicaments is very important also. Finally, the medicaments excel that has a variety of action mechanisms has the remedy of onefold mechanism only. Inferior Ren of amino candy N- base, Ren radical of DNJ and N- , DGJ whether as fight HBV medicine to still require further research. They are reached to CccDNA in " protective ground " if bile duct is epithelial medium the action of virus grain has not decide at present. As the addition that fights HBV medicaments measure, to the growth that uniqueness of medicaments of avery kind of understands character, in the light of the combination of distinctive patient and virus feature cure will appear. (the exercitation edits: Plum apricot)