Expert: Axil end "  of pacify wide river mouth

On medicine, the breed of virus is weighed for " duplicate " , because its unlike cell and helminth pass the means such as nucleolus dissension to breed in that way,this is, cast machine part like us however same, duplicate according to definite pattern come out. In duplicate process, have two very main factors: One is activator, another is pattern plate. Without these two elements, second liver virus cannot duplicate. Second liver virus is duplicate " activator " call Dna of second liver virus polymerization enzymatic (Hbv Dna-p) . This kind of enzymatic consist in the kernel of second liver virus, the core antigen with second liver virus (antigen of Hbcag) , E (Hbeag) and virus gene (the core that Dna) forms second liver virus jointly. Its action is gene of virus of liver of second of " catalysis " duplicate according to certain pattern plate a Dna catenary. Without the action with this kind of enzymatic polymerization, of second liver virus duplicate to be able to stop. Accordingly, restrain the medicaments with enzymatic polymerization of Dna of second liver virus, what can restrain second liver virus directly is duplicate. Second liver virus is duplicate " primitive pattern plate " it is Cccdna. Is this kind of primitive pattern plate how form? The gene group of second liver virus (Dna) is a when surround by the Dna catenary of two helix annular structure. Among them longer negative catenary has formed complete cricoid; another length is shorter catenary, show half cricoid. After infecting liver cell, this half cricoid Dna catenary wants to be pattern plate in order to lose catenary, lengthen below the action with enzymatic polymerization of Dna of virus of liver of second of activator ─ ─ , form finally complete cricoid. At this moment group of gene of second liver virus formed completely cricoid double stranded Dna. We weigh this kind of Dna to do covalence to close cricoid Dna(namely Cccdna) , can regarding it it seems that is the primitive pattern plate with duplicate virus. After pattern plate is formed, duplicate according to the appearance of pattern plate new virus gene is very easy. Virus gene can be pattern plate with an among them Cccdna, in using liver cell gene enzymatic with the " catalysis " with Dna enzymatic polymerization, a paragraph of gene ground of another paragraph of gene is duplicate, form negative chain, catenary. Final reload deserves to form Dna of new second liver virus together grain. Somebody duplicates Cccdna than becoming second liver virus " seed " , I think to compare it however do " weed root " suit more. Common saying says: "Unplug grass is easy, dig up the roots is difficult " , this kind of Cccdna is second liver virus the main intermediate product in duplicating, once it is formed inside liver nucleolus, had high stability, but long-standing within liver cell, not only removing what what a moment ago said " pattern plate " action, and still resemble deep take root keeps clear of completely very hard euqally in the weed in clay. Fight virus medicaments with what no matter, no matter the Dna inside afterbirth oar gets how old inhibition, the time that also uses drug no matter how long, all keep clear of very hard this kind of Cccdna. Want the Cccdna that there is very few amount inside liver cell only, after stopping drug, the Cccdna inside the nucleus can become the " model " with duplicate virus again again, continue to duplicate the Dna of second liver virus. After causing content of bane of a few disease-resistant to stop drug so " bounce phenomenon " . Second liver virus duplicates to also have " hibernant " when. Be in positive of antibody of E antigen negative, E when the second liver virus that contracts airframe " small 3 this world " when condition, it is the winter sleep with second liver duplicate virus period. At this moment, second liver virus is not had almost duplicate, its weed root Cccdna is concealed inside liver nucleolus to be in dormancy condition deeply. But the virus of this kind of condition is likely still " renascent " , because some kind of element causes his,may transform afresh the virus that is E antigen positive is duplicate condition. The winter sleep in second liver virus period, the patient's illness is relatively smooth, infectivity is very small also, but all disease-resistant bane thing are at present right also the dormancy virus gene that hides in the depth of the cell also how is not gotten. Accordingly, use in this one period why to plant disease-resistant bane content is infructuous. The mankind from discovery grain of second liver virus, confuse to what unlock virus duplicates, restrain the discovery of enzymatic medicaments of virus Dna polymerization to now again, one pace ground is ongoing. Believe before long, the medicaments of cut the weeds and dig up the roots, antagonism " winter sleep period " the medicaments of virus will appear, the mankind meets the one stubborn enemy of virus of conquer second liver after all. (the exercitation edits: Plum apricot)