Interferon treats solution of second liver detailed

What is interferon? What sort does interferon have? How does interferon treat second liver? What second liver suits interferon cure? Interferon has what undesirable reaction, if why are this handled? How much is interferon inject dosage? The interferon cure that this article will solve liver of second of ~ 　 one by one for you sums up 　 interferon (Interferon, IFN) is fight hepatitis virus at present effective remedy, but it is 30% ～ to the completely respondent rate of HBV 40% , it is the half the number of HBV about to HCV. As the development of molecular biology and odd clone technology, the sort of interferon with each passing day grow in quantity, curative effect rises somewhat, harmful response happens decrease. Choose different and phyletic interferon and remedial program to will have according to disease and illness restrain virus duplicate, relieve hepatic inflammation, prevent chronic liver disease then to eventually the concealment of evening liver cirrhosis the gender makes progress. The article is current interferon sort and clinical application circumstance make one overview, you also can land the interferon special subject of the website to learn more knowledge. One, interferon type 　 differs according to its origin minute of humanness leucocyte interferon (Interferon-alpha, IFN- α ) , interferon of cell of person fiber mother (Interferon-beta, IFN- β ) , human lymphocyte interferon (Interferon- Gamma, IFN- γ ) 3 kinds. IFN- α and IFN- β are I IFN, IFN- γ is Ⅱ IFN. 2, comfortable be recruited of cure of interferon disease-resistant poison and interferon of 　 of curative effect evaluation basically are used at course of diseases to be in above of half an year, mobile sex virus duplicates (serum HBeAg/HBV-DNA is electropositive, or HCV-RNA is electropositive) with acyl of ammonia of cereal of serum of ill 〔 of mobile sex liver amino move is enzymatic (Alanineaminotransferase, ALT) is elevatory, be more than normal value upper limit 2 times, be less than vivid check of 200 ～ 250IU/L; liver to show the patient of evidence of 〕 of hepatitis of chronic activity sex. Electronegative to HBeAg, HBV-DNA positive or HCV-RNA positive person also be disease-resistant poison cure to point to proof, but appropriate of period of treatment is lengthened appropriately. Cure of interferon of the person that normal to ALT chronic HBV/HCV is carried is much more invalid. (One) , different model the clinical application 　 that fastens interferon is different model other interferon because different of equal difference of its origin, structure, report also differs somewhat on clinical application. Current, use at clinical interferon to basically express place to show as follows. Interferon not (inferior model) get used to disease 　 　 disease of sex of virus of 　 of disease of sex of virus of γ of IFN of β of IFN of 　 of IFNa2b 　 of 　 of IFNa2a 　 of IFNa1b 　 　 , disease of sex of tumor 　 virus, 　 of 　 of rheumatoid arthritis of sclerosis of sex of tumor 　 much hair (2) , the commendation that common interferon treats chronic second liver dosage and appropriate of dosage of interferon of 　 of period of treatment are bigger, period of treatment cannot too short, it is 300 ～ commonly 5 million unit (Million Units, MU) , every week 3 (3 Times A Weektiw) , period of treatment 4 ～ 6 months. Electropositive to HBV-DNA but HBeAg negative, fight - HBe is electropositive person the likelihood needs 12 months. But, too large dose (Gt;10MU) or period of treatment are too long (Gt;12 month) may not can heighten curative effect. (3) , no-no disease: ⑴ serum bilirubin lifts be more than ⑵ of; of upper limit of 5 times normal value to break 　 of ⑷ of; of disease of immunity of oneself of ⑶ of sclerotic; of liver of acting countervail sex gravid, have serious heart, kidney disease suffers from or thyroid function hyperfunction or low; ⑸ is depressed disease or. (4) , harmful response: Main and harmful response is interferon flu appearance symptom, myalgia, arthralgia, exhaustion and lose one's hair, other response sees a table. Common response 　 reacts badly symptom of appearance of flu of infrequent reaction 　 , spirit is depressive, marrow restrains trichomadesis, morpheus uneasiness, lose weight, fatigue 　 has a headache, myalgia, skin roseola, arthralgia 　 attention cannot be centered, yi Ji causes mental nerve symptom, liver damages 　 thyroid gland the function is unusual, cardiovascular system of 　 of obstacle of pancreas islet function is injured, function of eye, ear damages pathological changes of skin mucous membrane, infection, disease of appearance of nephrosis of 　 of anaemia of haemorrhage hemolysis sex group artery of 　 vertebra base is not worth 　 kidney to damage 　 for blood the commonnest person to spend albuminuria gently, rare Gt;0.1 is overcome / day, also do not accompany those who have serous egg white to decrease. Although have a story,other kidney is damaged but extremely scarce. Normally need not special processing, the patient waters more can. Insomnia of neurological symptom 　 , angst, depressed, excited, irritable, mental disease. Appear depressed reach mental symptom to should stop drug. The initial stage of treatment of patient of generation 　 part of antibody of interference rejection element appears namely antibody of interference rejection element, the influence treats the effect. Estimation and individual difference are concerned, according to A of statistical 　 　 , rate of generation of 2a interferon antibody is high, with application length of dosage, way giving drug, time and patient age do not have clear impact. To the influence of internal system coriaceous steroid of hydroxide of 　 　 11- increases, estrogen level falls, high density spends lipoprotein to reduce, occurrence sugar make water, see the disease such as calcium of tall blood Potassium, low blood occasionally, still can raise serous triglyceride content, but do not have an influence to cholesterol. (the exercitation edits: Plum apricot)