Tuesday, 20 February 2007
The optimal opportunity that interferon treats
In outpatient service, we often come up against a lot of second liver patients to be eager to undertaking disease-resistant poison is treated, this kind of viewpoint is incorrect actually. The natural course of disease that chronic hepatitis B contracts includes 3 level: ① immunity is able to bear or endure suffer period: This stage show is HBeAg positive, common calls " big 3 in relief " , HBV-DNA level is high, liver function is normal, but clinical without the symptom, often be in check-up or the discovery when making other inspection. This phase does not need disease-resistant poison to treat, but must 6 months follow 3 ~ visit; ② immunity is cleared period: Patient liver function relapses unusual, serum HBV-DNA drop spends on any account, this period is the important period that earnestly requires to fight virus to treat, and remedial effect is better; ③ is low-level duplicate period: HBsAg positive exists continuously, HBeAg but electronegative, HBV- DNA shows small amount level, the part develops the sclerosis that it is liver and liver cell liver cancer, the disease-resistant poisonous curative effect of patient of this period great majority is inferior to person meaning, even partial patient can appear during cure the illness is aggravating. The patient is like the person that appear to cross ascites or have small white blood cell, low plaque, diagnose the patient that loses acting countervail for liver cirrhosis namely, unsuited application interferon. So, the patient needs before cure notice him dawn is in what condition, take corresponding step in order to cooperate a doctor, it is regular outpatient service is followed visit or fight virus to treat instantly, or cannot fight virus to treat. Regard a specialized subject as the doctor, need observes the patient's condition closely, offer attentive guidance. α - the first selection medicaments that interferon is the disease-resistant poison treatment that is used at hepatitis. The cause that fights ill poisonous cure is: Block breaks the virus inside body to duplicate, reduce the amount of virus, final cleared virus; Control hepatic inflammation reaction and necrotic pathological changes, improve liver function; Improve long-term and clinical prognosis, include to defer or the happening that block breaks development to be the liver cell liver cancer related liver cirrhosis and precautionary hepatitis B; Lengthen live period and improve life quality. Have α at present - interferon is newest the form of a drug- - Gan Le can be much dosage pen, it is only can be brought to the patient convenient and the α that reduces anguish again - injection of 2 B interferon water. Every pen is embedded unit of 18 million international, every 3 million unit is 0.2 milliliter only, inject pinhead is the finest on eye preexistence bound, distinctive exterior silicon is changed reach polishing patent technology, make its exterior attrition force is almost 0, came true not to have painful inject thereby. Through the test of time, α - interferon already fought virus in second liver dominant position is held in cure, but the recrudescent issue that also is put after stopping drug, this is an objective fact. After interferon injects general 4 ~ can give out heat 6 hours reach the flu appearance symptom such as systemic ache, should drink water more only at this moment or take solution to heat up demulcent medicine appropriately, can alleviate by oneself commonly. But along with visit Shi Refa to have leucocyte and plaque to decrease, but take into consideration the circumstances adjusts dosage, the remedy that out of service observes or uses litre of leucocyte and plaque even waits for index to rise to proper limits to adjust interferon stage by stage again optimal cure dosage. Regular outpatient service must be accomplished to follow seriously during cure visit, if the harmful response such as disease of immunity of icteric, depressed, oneself appears in inject interferon process, must stop drug. Although second liver does not require lifelong treatment, but before effecting a radical cure the medicaments of this one disease comes out, must lifelong along with visit, the change of dynamic observation disease, discovery undertakes specific aim is treated as early as possible after the circumstance. The person that this affects to each HBV, it is necessary. (responsibility edits: King sea E)
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