Monday, 19 February 2007
How to prevent second liver " stage a come back " ?
In the process that treats in poison of second liver disease-resistant, stop the treatment to the patient prematurely, in the danger that turns a lot of patients possibly to serious liver disease and liver cancer. In 3233 patients that accept investigation, the patient that has 74% about develops the sclerosis that it is liver and liver cancer on average when 57.2 years old. For this, the institute of research of Asia-Pacific liver disease that held a few days ago on the 17th annual meeting, delibrate of ill expert of liver of thousands of international the newest progress that second liver treats, the latest edition that appeals disease of liver of use United States studies association was announced 2007 " guideline of second liver prevention and cure " . Stop prematurely to treat Ma of university of Hong Kong of of of virus stage a come back head of department of beautiful hospital medicine Professor Li Qinglong introduces on annual meeting, in the person that at present the chronic second liver of 350 million affects the whole world, 75% live in the Asia, among them China is had about 130 million. Every year about 520 thousand die at liver cirrhosis and liver cancer. The nucleotide that is used the earliest at fighting second liver virus kind medicaments, in applying for a long time, virus already arose gradually be able to bear or endure property of a medicine, make originally effective remedy becomes no longer effective. Active " guideline " proposal patient, once their virus holds an amount -- , namely the content of virus of liver of the second in blood -- , transaminase level reduces cereal third to detect be restricted to already produced E antibody below, so be about to stop to use drug. And newest research discovery, once stop treatment prematurely, virus will continue to undertake to liver the gender is destroyed revengeful wantonly. Consider to discover, in 3233 patients that accept investigation, the patient that has 74% about develops the sclerosis that it is liver and liver cancer on average when 57.2 years old, although they produced the E antibody of second liver on average when 35 years old. For this, new edition " guideline " put forward: The first goal that chronic second liver treats is " abiding restrain second liver virus (the duplicate, delays hepatic disease progress of HBVDNA) " , ultimate goal is " the happening that prevents exhaustion of liver cirrhosis, liver function and cell of cancer of the liver " . Second liver cure must fight virus for a long time to treat newest guideline thinks, treat a cause to achieve second liver, must hold to long-term disease-resistant poison to treat. And the main problem that long-term second liver treats is to fight virus to be able to bear or endure the generation that medicine mutates, accordingly, to initiative cure patient, be about at the beginning from cure preferential choose disease-resistant poisonous ability strong, be able to bear or endure the medicaments with medical low rate. Current, decrease be able to bear or endure the amount that medical occurence rate is the virus in reducing blood above all perhaps reduces virus to hold an amount as far as possible, best can fall to under detect bounds level. Because, virus is duplicate lower, the possibility that produces mutation is less, be able to bear or endure the happening that medicine leads is lower also. Next, medicaments itself should be had taller " be able to bear or endure medical gene protective screen " , namely virus should be in several an ability when nodding coinstantaneous mutation can happen be able to bear or endure medicine mutates. New pharmaceuticals if favour compare first disease-resistant bane thing for Ka Wei, curative effect is better, the capacity that controls virus to duplicate is stronger, be able to bear or endure medicine leads lowest, be recommended to be main a gleam of to use drug by congress. Big 3 in relief patients can treat a lot of people of to discover when check-up as early as possible big after 3 this world, do not check cure further into normal hospital, take health care to taste in disorder however, the expert points out such doing illness of probable incur loss through delay. Mount Hua hospital infects Weng Xinhua of adviser of division professor, doctoral student to introduce, at present the technology such as liver puncture can help a doctor judge this kind of patient to whether need to be treated immediately. Once diagnose, should undertake disease-resistant poison is treated, so that control an illness in time,develop. Never the folk prescription chaos of mountebank of believe what one hears is treated. This Asia-Pacific annual meeting is being recommended when using drug, mention, when choosing a gleam of to fight medicaments of second liver virus, do not recommend use for a long time be able to bear or endure the medicaments with medical high occurence rate. In outpatient service, weng Jiao is awarded inspect patient economy condition commonly and decide. If patient economy condition can be assumed, use disease-resistant poisonous capacity at the beginning strong, be able to bear or endure medical rate is low, but the price slightly if,tall favour replaces the new drug; such as Ka Wei patient economically very difficult, first short-term the substance of other disease-resistant bane with use drug relatively cheap price. But, once the patient appears,be able to bear or endure property of a medicine, change only with new drug, this moment increases accordingly with medical dosage, expenditure also is met bigger. (the exercitation edits: Plum apricot)
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