Admire is happy can have with clique collect star why to differ

1, are two the lasting effect interferon that a week hits? , but inferior model different. Admire is happy can be interferon Alpha-2b, it is human body inside original with respect to some " natural " interferon, sending Luo Xin is interferon Alpha-2a, not be natural interferon. Admire is happy can be production of elegant company of American Xian Lingbao, sending Luo Xin is production of company of Swiss collect family name. 2, admire is happy can be pure entrance product, sending Luo Xin is product of domestic cent outfit, in Shanghai cent is installed. 3, interferon of two kinds of lasting effect is call those who do not have active to get together to the material of glycol and interferon are linked together and be become with a kind, in order to lengthens medicaments half-life, achieve the goal that a week gives drug, but of two kinds of medicaments get together glycol element measurement is different, admire is happy can medium get together glycol is 12KD, clique collect glad gets together mediumly glycol is 40KD, clique collect glad is happier than admire can the member became old 36KD did not get together actively glycol. 4, admire is happy can half-life is 40 hours, the half-life that sends Luo Xin is 80 hours, send Luo Xin to grow in the time inside body. If have drug 48 weeks, the admire after stopping drug is happy can need 10-14 day from the time of complete eduction inside body, send Luo Xin to need 28-56 day, so, if worry about severe undesirable reaction, happy with admire can a few safer. 5, admire is happy can disease-resistant poison is active and apparent prep above sends Luo Xin, it is 25 times of active of clique collect glad. Because get together,this is glycol is bigger, jump over interference and the couple that accept put oneself in another's position, active is lower. Sending Luo Xin's active to drop is to rely on its long-term inside body effect will compensate, but if appear severe undesirable reaction, stop medical difficulty. 6, admire is happy can active is square international unit 7 when every milligram contains 9X10, the active that sends Luo Xin is square international unit 6 when every milligram contains 3.2X10. Conversion, admire is happy can 3 kinds of norms the active of 50 microgramme, 80 microgramme, 100 microgramme is respectively 3.2 1 million, 5.6 1 million with unit of 7.2 1 million international, and send Luo Xin 135 microgramme and the active of 180 microgramme part 1.9 1 million with unit of 2.5 1 million international. 7, admire is happy can give drug by the patient's weight, send Luo Xin to give drug by fixed dosage. 8, admire is happy can treat Chinese gene 1 model the curative effect excel of third hepatitis sends Luo Xin. Because whole body of third liver virus distributings,this is, because the member is old,send Luo Xin, cannot distributing all over, so, have a relapse easily. Admire is happy can the member is young, can distributing all over, the virus of cleared whole body, have a relapse not easily. The biggest clinical trial IDEAL tries check proof, admire is happy can curative effect prep above sends Luo Xin. 9, the analytic result of patient of liver of many 800 third, admire is happy can recrudescent rate is 13.8% , the recrudescent rate that sends Luo Xin is as high as 30.7% . 10, admire is happy can treat a Chinese the curative effect prep above of chronic second liver sends Luo Xin, second liver virus has a few kinds of kinds, the Chinese is the commonnest is B model with C model, to C model curative effect, admire is happy as can similar as clique collect glad, but to B model curative effect, admire is happy can exterior antigen turns Yin Lvming shows prep above to send Luo Xin, it is respectively 9% with 0% 　 reference material: Admire of 　 of Lancet 2005; Hepatology 2006;Am J Hepatology 2006 is happy can be to get together glycol interferon Alfa-2b, namely of common interferon Alfa-2b get together glycol is changed, what use get together glycol element quantity is 12KD, KD is the unit that states the element measures volume. Sending Luo Xin is to get together glycol interferon Alfa-2a, what use get together glycol element quantity is 40KD, bipeile can be big 36 KD. And the molecular amount of interferon Alfa-2b and Alfa-2a is similar big little, admire is so happy can the element measures element of the Luo Xin that compare a group to measure small 36KD, this 36KD is did not get together actively glycol. Accordingly, can saying admire is happy can be the lasting effect interferon of young member, sending Luo Xin is the lasting effect interferon of macromolecule. The advantage of interferon of young member lasting effect was to still withhold the kidney of 30% to excrete, can distributing in the whole body. Interferon cure produces undesirable reaction via regular meeting, serious meeting produces serious leucocyte and plaque to decrease, need to stop drug in time at this moment or reduce an amount, admire is happy can because the member is young, can from nephritic eduction, after stop drug or reducing an amount, medicaments from what drop inside blood faster, so, security is higher. And the clique collect glad of macromolecule is in of the kidney excrete rate for 0% , cannot excrete completely in the kidney. This brings two potential problems, it is to should happen when serious and harmful response stops drug, the medicaments chroma inside blood drops slow, according to document report, the 1-2 after stopping drug lunar ability keeps clear of completely, undesirable to decreasing reaction is very adverse. Another problem is, majority of clique collect glad distributings in liver, accentuated so the hepatic burden that has been injured originally. Still have, hepatitis virus distributings to be given priority to with liver all over, the virus that if medicaments is centered in liver only,organizes to other is cleared and adverse, stop medical hind easy recrudesce, more and more clinical trials make clear, the recrudesce that sends Luo Xin to treat third liver leads outclass admire happy can. The place on put together is narrated, admire is happy can security is higher than sending Luo Xin to want, although produce undesirable reaction possibly. Burden of liver of accentuation of clique collect glad, recrudescent rate is high. (the exercitation edits: Plum apricot)