Tuesday, 10 July 2007
Be able to bear or endure to second liver opportunely 9 big subtle move of medicine
Second liver virus is able to bear or endure medicine already became current second liver to treat the challenge with the biggest field. In second liver cure, be able to bear or endure once medical case happens, fight virus medicaments effectively originally restrain virus to duplicate ability can be reduced greatly. In the meantime, be able to bear or endure medicine can bring about an illness to relapse, the undesirable consequence such as disease progress, and the across between medicaments is able to bear or endure the choice that medicine also can treat to sequel brings huge difficulty. News background: Media reported recently, china has liver of more than 100 thousand second at present patient happening is able to bear or endure medicine. Academician of Chinese Academy of Engineering Professor Zhuang Hui thinks, second liver virus is able to bear or endure medicine already became current second liver to treat the challenge with the biggest field. In second liver cure, be able to bear or endure once medical case happens, fight virus medicaments effectively originally restrain virus to duplicate ability can be reduced greatly. In the meantime, be able to bear or endure medicine can bring about an illness to relapse, the undesirable consequence such as disease progress, and the across between medicaments is able to bear or endure the choice that medicine also can treat to sequel brings huge difficulty. Virus mutation is able to bear or endure medicine is the main trend that liver of second of cure of analogue of inevitable use nucleotide has made liver of second of current and clinical cure, area of Europe, United States, Asia-Pacific and our country label his the necessary medicines that second liver prevents and cure. The common characteristic of these medicaments is profess to convinced goes to the lavatory, can restrain second liver virus quickly, prevent or defer progress of chronic second liver to be liver cirrhosis, liver cancer. But these medicaments have again " common fault " , it is period of treatment endless, cannot stop drug easily, stop medical hind easy recrudesce, produce virus mutation possibly still to bring about be able to bear or endure medicine comes into being. Actually, virus mutation appears to be able to bear or endure in treating second liver process medicine is belonged to inevitable. Virus gene mutation exists extensively in nature, also but by medicaments revulsive generation. Virus mutation appears to be able to bear or endure in fighting virus to treat a process medical problem is serious, but be not disaster, cannot remedy, answer actively, can will be able to bear or endure the risk of medical problem falls to lowest. How to discover second liver virus is able to bear or endure medicine? During the patient is being treated originally curative effect is pretty good, DNA of virus of serum second liver is restrained for a time, virus carries a quantity to drop apparently, but the virus in continueing to treat a process carries a quantity to rise slowly again, be worth photograph comparing with descendent lowest, lifted 10 times above, confirm via checking again, this means virus to be able to bear or endure medical happening, say on medicine learn a breakthrough for virus. If treat the effect originally pretty good, abrupt virus carries a quantity to rise unit of more than 20 thousand international / rise or be the level before prep above is treated, this calls virus bounce. If virus holds an amount slowly answer rise while, serum transaminase level also rises to normal level above, because virus is duplicate,this was mirrorred horizontal addition, cause hepatic inflammation activity, say on medicine learn a breakthrough for biochemistry. During cure, need fixed observation to be able to bear or endure whether does medicine happen, the time interval of general examination is half an year, level of DNA of virus of liver of second of serum of examination of main laboratory test, be able to bear or endure medical gene alignment and liver function. Current, hospital of specialized subject of contagion of area of Beijing and other places can use PCR enlarge to add DNA of second liver virus to get together more the method such as analysis of enzymatic gene alignment, detect second liver virus is able to bear or endure medical gene. How is precaution able to bear or endure medical happening? Be able to bear or endure for precaution medical happening, can take the following step. One, the disease-resistant bane thing that uses powerful effect, restrain virus to carry a quantity to come continuously quickly cannot measure a level. Virus is able to bear or endure medical happening and virus control rate closely related, decrease be able to bear or endure the amount that medical occurence rate is the virus in reducing blood above all, perhaps reduce virus to hold an amount as far as possible. Virus is duplicate lower, the possibility that produces mutation is less, be able to bear or endure the happening that medicine leads is lower also. 2, the choice is had be able to bear or endure high the disease-resistant bane content of medical gene protective screen, need many to nod namely at the same time choppy ability generation is able to bear or endure medical medicaments. "Be able to bear or endure medical gene protective screen " be just like a wall, an odds of a dot happening mutation is probably 50 thousand 1/0, and 3 an odds that nods coinstantaneous mutation be in 1/10000000 the left and right sides. Initiative cure should choose to fight virus active strong, low be able to bear or endure medical medicaments, this has been bound of current international medicine the consensus that treats to chronic second liver. 3, raise the comply with sex that uses drug, before having treatment, the patient should understand the time of whole cure and the note in treating a process, establish remedial record at the same time, follow regularly visit. The patient should put an end to abusive medicaments, not optional out of service, doctor's advice of strict comply with takes drug. 4, during strengthening whole disease-resistant poison to treat monitor, every 3 months need to detect 1 times to half an year virus is duplicate index and virus are able to bear or endure medical gene alignment. If be able to bear or endure,medicine appears, need basis patient patient's condition, economic atmosphere and be able to bear or endure medical clew undertakes medicaments is adjusted. 5, disease-resistant poison treats the curative effect inside 3 months not apparent, need adjusts plan in time, change other medication. 6, avoid cure of follow in a continuous line of only drug order. Do not use husband of rummy of period of time to decide, change Adefuwei again, change Cheng En to replace Ka Wei again for some time too, this is very wrong. 7, not blind combination uses drug. Interferon combines nucleotide kind disease-resistant bane content cannot add curative effect. A few kinds of nucleotide kind medicaments is used jointly bring about much medicine across to be able to bear or endure likely medical case happens, undeserved also advocate. 8, master disease-resistant poison strictly to get used to disease, normal to liver result, the patient that also does not have evidence of liver histology inflammation does not use disease-resistant poison to medication easily. 9, disease-resistant poison treats whole process to need the requirement according to guideline of second liver prevention and cure, start well and end well, be not changed at will or stop treatment. Be once happen, able to bear or endure how does medicine do? Be able to bear or endure after medical happening, the doctor is met the outcome that according to be able to bear or endure medical virus gene measures order, for the patient the choice was not able to bear or endure those medicaments of medicine undertake remedying cure. For example, rummy husband is able to bear or endure surely medicine: One, add use or convert Adefuwei. 2, convert favour for Ka Wei (one day two) . 3, convert Truvada(favour music he bank with the compound preparation) that replaces Nuofuwei. 4, add with Wei of the husband that replace Nuo. Be aimed at ester of A Defu Wei be able to bear or endure medicine: One, add with for replace than the husband is decided or converting than the husband calm; is added use or convert rummy husband is decided. 2, add with favour for Ka Wei. 3, convert favour for Ka Wei. 4, convert Truvada. Favour the Wei Naiyao that replace card can choose: One, add the Defuwei that use A. 2, convert Adefuwei. 3, add with Wei of the husband that replace Nuo. 4, convert for Nuofuwei. If appear afore-mentioned nucleotide kind of disease-resistant bane content be able to bear or endure medicine, also can convert interferon gets together especially glycol turns interferon treatment. (the exercitation edits: Plum apricot)
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