Sunday, 22 July 2007
The liver that treat second need not perpetual
Go up to sufferring from the patient of chronic second liver, normally as will lifetime as medicaments photograph companion, this may appear not only medicaments side-effect and be able to bear or endure property of a medicine, and bring heavy economic burden to the patient. Recently, hold in Hong Kong ill conference of liver of international of 2008 harbor Shanghai go up, asia-Pacific liver seminar (APASL) was rolled out chronic second liver manages Asia-Pacific of new 2008 edition guideline , release a lot of new disease management and remedial proposal among them, caused many 2200 to come from the attention of expert of country and the area such as Taiwan of Hong Kong of the United States, Japan, India and China, China, China attending the meeting. The Asia-Pacific liver disease such as Liao Jiajie of professor of college of Chairman APASL, Hong Kong studies the expert introduced 16 proposals in new edition guideline, emphasize it unscrambled a few is important to unscrambled a few new research achievement. Stop medical principle clearly to enhance disease of liver of second of patient confidence to relapse easily, virus mutates extremely easily, so the patient depends on medicaments control for a long time, this kind without terminus cure gives patient body and mind and economy to bring double pressure. New guideline advanced clear principle stopping drug first: To the patient of E antigen positive, in interval in two examinations of at least 6 months, all show serological changeover and virus detect electronegative, come true namely clinical those who go up is double amount to mark, consolidate after treating a year, with respect to terminable cure, this comes true as early as possible for the patient stopped medicine to bring a hope. New guideline points out, serum changeover means antigen of the E in blood (the virus that a kind of cell that already infected second liver virus secretes is protein) decreased, produced antibody at the same time, show resist the immunity that second liver virus affects is respondent strengthened. Professor Liao Jiajie says, consider and clinical show, serum changeover is a very main index, if the patient reachs this target, consolidate after treating a year, can consider to stop drug, and illness aggravation, suffer from on other liverish possibility is inferior also. The research that Professor Lin cited to be finished recently comes to gold of Hou of committee member of vice director of chapter of infection of China cure society as a result DNA of the virus when proving to be in 24 weeks detects the importance of the result. Participate in the patient of the E antigen positive of this research, taking a gleam of to treat medicaments to replace after deciding 24 weeks than the husband, if NDA of second liver virus does not detect, the opportunity that serum changeover realizes after two years is close 50% above, and the patient of nearly 90% still does not detect in level of the virus after two years. of medicaments of class of use B of of proposal gestation woman suffers from on the woman of second liver wants to be pregnant parturient, the doctor asks the patient stops to take drug normally. This gives treatment successional brought an issue. Protect the child or keep pregnant woman? this is problem of be in a dilemma . This new guideline first bold put forward: To accepting the gestation woman that profess to convinced medications, the proposal can use remedy of gravid B class. Medicaments of gravid B class is the medicaments that points to safety of course animal experiment. New guideline emphasized the individuation that second liver treats particularly, the patient's condition that pair of patients want when appealing the doctor decides disease-resistant poison treats plan, phase, familial history, the element such as remedial history and economic condition undertakes be assessmented in the round mixing necessary communicate, raise sex of remedial comply with. Professor Liao Jiajie says, new guideline enlarged a doctor the sort of medicaments of a gleam of of clinical first selection, just was replaced recently to compare a husband to wait for 4 kinds of nucleotide surely by what American FDA labels medicaments of gravid B class (acerbity) medicaments includes among them, make treated individuation to have more choice. (the exercitation edits: Plum apricot)
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