Saturday, 28 July 2007
The error of poison of second liver disease-resistant is great
1, disease-resistant poison cure nots matter because the person that virus of liver of a lot of second carries does not have clear unwell sense at ordinary times, so they do not wish for a long time go to a doctor, do not accept the doctor's system to treat, abandon what periodic liver function and virus learn index monitoring even. And once appear when unwell feeling, the most person in them often has developed be heavy-duty hepatitis or liver cirrhosis is terminal. Really, the person that virus of some second liver is carried but all one's life do not come on, patient of most and chronic hepatitis is spent gently in transaminase apparent symptom also is not had when lifting. But second liver virus is in like conceal however inside body " time bomb " , can make the cause of disaster at any time. Accordingly, the person that second liver virus is carried should check liver function and second liver virus to learn index to the hospital regularly, once discovery is unusual, should instantly go to a doctor, according to the doctor's cure plan undertakes disease-resistant poison is treated. 2, believe of a few advertisement blindly the disloyal content that patient of liver of a few second believes certain advertisement is medium blindly to treat a disease. Actually, a kind of significant disease-resistant bane thing wants to go up according to international unified medicines and chemical reagents is clinical experiment government is normative (GCP) standard, before the course is clinical (be aimed at an animal) , I period (in the light of patient of healthy person and minority) , Ⅱ period and Ⅲ period (international much center, double blind contrasts) clinical research talent appears on the market formally. Some of medicaments passes Ⅳ period clinical research even. In these experiments, people should observe the effectiveness of medicaments not only, observe its security even. Whole process needs 2-3 at least year time. Before these experiments end, everybody cannot conclude some kind of medicaments is in clinical go up to be mixed effectively for certain safe. And some manufacturer to seek profit, boast arbitrarily in advertisement unexpectedly, misdirect consumer, make a lot of people do not have the goal that achieves cure not only after using drug thereby, still make an illness more serious. 3, the disease-resistant bane that did not get used to card to also treat hepatitis B with medical belongs to prescription drug, its are optimal getting used to card is transaminase of third of positive of DNA of second liver virus, cereal (ALT) fluctuates repeatedly the patient of hepatitis of chronic activity sex between 100-300 unit. Additional, patient of cirrhosis of a few liver and liver (kidney) the person that transplanting art, tumour changes cure period and the infection of second liver virus that surround operation period also can be used. But the patient with a few normal liver function to achieve " cleared " the purpose of second liver virus, treat by oneself unexpectedly, although the goal that HBV DNA shade turns can be achieved in remedial initial stage, after can stopping drug, its assay index can lift again. This makes patient generation is able to bear or endure easily property of a medicine, it is even when cure of poison of real need disease-resistant, cannot choose significant curative thing. Accordingly, the sort of way that buys medicine, optional cure by oneself is very wrong to second liver patient with danger. 4, cannot hold to disease-resistant poison to treat drug is used when patient of liver of a few second is undertaking disease-resistant poison is treated not the rule, or the initial curative effect that just achieves HBV DNA shade to turn already was kept clear of for virus with respect to mistake, do sth without authorization stops drug. Such cure removes the inhibition that is less than pair of second liver virus not only, make patient generation is able to bear or endure possibly still property of a medicine, make even of virus duplicate rebound, accentuate thereby illness. Because,this is, the main effect of medicaments of virus of a few liver that fight second is the duplicating that restrains second liver virus. The patient used drug, of second liver virus duplicate abate or stop, once stop drug, second liver virus is new and active. This shows, second liver patient must use drug by period of treatment, restrain the purpose of virus in order to achieve continuously. 5, do not undertake periodic monitors to fought medicine of second liver virus to achieved curative effect and patient to whether arise to be able to bear or endure during cure property of a medicine, during main support is treated monitor regularly. After treating 3 months, HBVDNA drop of the patient is spent did not see drop, with respect to the specification this kind of medicaments does not have curative effect, should change if the disease-resistant bane; of other achieves curative effect, the bounce of HBVDNA and ALT appears during if use drug,medical; stopping again after can continueing to treat period of time, demonstrative virus produced mutation or the patient had arisen to be able to bear or endure property of a medicine. Additional, some disease-resistant bane can have a few side effect, if interferon can cause white blood cell,drop, liver function is unusual thyroid even function is unusual wait for harmful response. If the patient does not undertake during using drug periodic is monitored, with respect to the curative effect that cannot judge medicaments, cannot discover a few undesirable reaction that medicaments place causes in time, and appear easily serious consequence. 6, of overly scared virus mutation a few patients although the drop of HBVDNA is spent very tall, liver function is long-term also and unusual, but because cross minute of ground fear,virus mutates and dare not use disease-resistant poison. This makes virus duplicates ceaselessly inside the patient's body, liver cell is necrotic exist continuously, liver function is long-term and unusual, its are to cause a large number of fibre proliferation inside liver as a result (liver is sclerotic) or because hyperplasia is excessive and cause liver cancer. Actually, virus mutation is very normal phenomenon, without what terrible. All biology on the world can produce mutation. Because,this is, the mankind should restrain the growth of virus with medicaments, and virus itself also wants ceaselessly acclimatization. For example, flu virus produces mutation every year, but annual people can make a new vaccine come. Same, the bacteria also can happen mutation. For example, after the patient is using penicillin of period of time, can be able to bear or endure to its generation property of a medicine. Accordingly, once the patient is able to bear or endure to generation of some kind of medicaments property of a medicine, should convert in time the medicaments of other continues to treat. 7, " small 3 this world " the patient need not treat generally speaking, those who be in infection of second liver virus " small 3 this world " condition belongs to second liver virus to duplicate " winter sleep period " , right now the second liver virus inside patient system duplicates scarcely, liver function is normal also, beardless cure. But part " small 3 this world " the patient can appear the iteration of liver function is unusual, because contracted the second liver virus that area of the one C before planting mutates,its reason may be. These patients although the E antigen in serum is electronegative, still meet inside its body of DNA of virus of long-standing second liver duplicate (HBVDNA positive) , the illness also can make progress ceaselessly. Accordingly, such " small 3 this world " the patient still needs to undertake disease-resistant poison is treated. 8, the evening when liver cirrhosis patient undertakes cure already was fighting virus the patient's condition that has some of second liver patient has developed the cirrhosis that it is liver, appeared even the performance that the liver function such as haemorrhage of liver ascites, enteron, hepatic coma breaks acting countervail. These patients often lost confidence to cure, the evening when thinking to undertake cure has been been fighting virus. Actually, the new generation nucleotide that appears on the market in recent years kind medicaments of virus of the liver that fight second can alleviate not only the illness of liver cirrhosis patient, and very safe still. Be in early 1996, abroad medications with this kind with respect to somebody liver is sclerotic, obtained better curative effect. In recent years, the research that poison of disease-resistant of sclerotic to second liver and liver patient treats group of domestic and international medicine all obtained greater progress, accumulated certain experience. Accordingly, liver cirrhosis patient falls to still can be mixed in the doctor's guidance in certain condition monitor next undertaking that disease-resistant poison is treated, alleviate in order to achieve the purpose of the illness. 9, use of disease-resistant bane content jointly blindly in recent years, a few patients keep clear of to achieve the purpose of second liver virus, use the remedy of virus of a variety of the liver that fight second jointly blindly. Actually, the action mechanism that majority fights drug of second liver virus is identical. Still have a few remedy, although their action mechanism is not same, but through in last few years clinical research, people did not see combination uses medicine to be able to use bane of a kind of disease-resistant obtain better curative effect than sheet. Additional, second liver virus also the resistance to the action of a drug of unlike AIDS virus is so strong, need not use a variety of disease-resistant poison jointly (" cocktail " therapeutics) can restrain its to duplicate, and second liver virus is very sensitive to disease-resistant bane, the nucleotide of the new generation that the patient of 80% above uses small dose kind medicine, can achieve the goal that restrains second liver virus to duplicate. Accordingly, in recent years most expert thinks, the patient should not use drug of virus of the liver that fight second jointly blindly, and should adopt use poison of a kind of disease-resistant first, the order follow in a continuous line that another kind of medicine changes again after period of time treats a method, just change the optimal opportunity of medicaments and breed still are in research. 10, after the expectation that antagonism virus treats is worth the person that virus of liver of a few second affects exorbitant to be discriminated against socially, go after pressingly alleged " turn shade " cure, defy the medicaments of second liver virus expresses exorbitant hope. During disease-resistant poison is treated, they carelessly the inhibition of the improvement of liver function and DNA of second liver virus, and shade of blindly antigen of surface of virus of expectation second liver turns. Actually, medicine of current virus of the liver that fight second can rise to control the function with second liver duplicate virus only, not can second liver virus from keep clear of completely inside body. The end that disease-resistant poison treats just also restrains the duplicating of second liver virus, with alleviating the pathology of patient liver cell is damaged, improve hepatic function. To such cure, the patient must have " call protracted battle " psychological preparation, only such, ability makes second liver virus is in for a long time control a state, achieve HBV DNA shade to turn thereby, liver function restores, E antigen shade turns, appear of second liver virus " hibernant " state. (the exercitation edits: Plum apricot)
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