Friday, 27 July 2007
Got second liver hopeless?
Got second liver, hopeless, such, restrained virus to calculate. do you have such idea? The following content picks from: IHBV affects chronically disease-resistant poison treats research to make progress, long treat journal of college of medicine expert of the 20th the 3rd period combined theory and clinical practice in September 2006, to the chronic hepatitis B of HBeAg positive, the target branch that the proposal treats disease-resistant poison is 3 administrative levels, regard certain treatment as terminal important and referenced target: Ⅰ class target: Obtain complete serological respondent (HBsAg, HBeAg all turns shade) , complete virus learns respondent (HBV DNA turns shade) with biochemistry respondent (ALT is removed a month detects 2 times continuously all normal, liver function answer constant) . This is optimal target and remedial terminus, but general very inaccessible. The patient α of Asian area - the person that this target is amounted to after interferon standard period of treatment ends is not worth 3 % , the person that the patient of Euramerican and other places is not worth husband of 10 %; rummy to decide cure to be able to amount to this target is rarely seen. Ⅱ class target: Obtain complete (HBeAg turns shade, fight - HBe turns in relief) or the part is serological respondent (HBeAg turns shade, but did not appear fight - HBe) , complete virus learns respondent with biochemistry respondent. Can regarding this is clinical and complete respondent . Make an appointment with α of period of treatment of standard of 33 % classics - the interferon cure, patient that makes an appointment with husband of rummy of 16 % classics to be treated surely 1 year is expected to amount to this target. Ⅲ class target: Fail to obtain serological respondent, but obtain quite the virus of degree learns respondent (restrain HBV DNA for long to duplicate, DNA drops ≥ 2 amounts class) with biochemistry respondent (liver function improvement or normal) . Unscramble: From the point of present medical treatment level, second liver is treated very hard really, but not be to cannot say complete incurable, after all still a few patient can achieve exterior antigen to turn via cure shade, appear exterior antibody, achieve such index to also mean second liver to won't have a relapse again, and had the resistance in the light of second liver, achieved namely so called clinical cure. Next, a lot of media and patient think second liver is one treats bad illness previously, affected second liver had be toed treat for a long time or this says lifelong cure, this kind of viewpoint is in country is very common, estimate in doctor frame of mind not little also, consider possibly also to be concerned lesser related to home. The opportunity that Euramerican data indicates to cure of interferon of classics of patient of chronic second liver has 5%-10% can achieve exterior antigen to turn shade, namely clinical cure: It is the foreign data that literary works of a science of domestic cites below, provenance: Poison of disease-resistant of chronic second liver treats the current situation and research progress, internal medicine of #8226; of Chinese medicine abstract learns 2005 the 26th the 6th period: Wong be in gross patient of 837 chronic hepatitis B accepts interferon α 5-10MUI/d or every week 3, 4 ~ the HBV-DNA after the cure of 6 months lasts shade turns rate 37%(contrasts group 17%) , HBeAg disappears or 33%(of serological changeover rate contrasts group 12%) , HBsAg lasts shade turns rate 7.8%(contrasts group 1.8) . Domestic data although dimensions still is not very big, but let us see a hope however, pick from: Get together glycol changes interferon α - the clinical research that 2a treats chronic hepatitis B, china is hepatic and magazine November 2006 the 14th the 11st period: Get together glycol interferon α - 2a treats chronic second liver 30, after cure ends, follow visit 48 weeks (drug stops after treating an end namely, continue to follow next visit 48 weeks of) , antigen of 3 occurrence surfaces turns shade, move is led 10% , among them after 2 appear in cure 32 weeks, 1 gives 24 weeks to treat end hind now. Although at present second liver cures the patient's case,the report still is not very much, but we should see a hope, want to be striven for actively, face second liver actively, go actively treating, abandon negative attitude, do not say easily second liver is hopeless, such, restrained virus to calculate. (the exercitation edits: Plum apricot)
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