With the course that hepatitis B rich weichis

Virus sex hepatitis is one of the commonnest infectivity diseases on the world. The epidemiology material that seizes World Health Organization shows, all over the world in 6 billion population, make an appointment with 1/2 to live in second liver virus (area of travel of HBV) Gao Liu, about 2 billion person ever affected HBV, the person that affect chronically amounts to 3~4 100 million, because hepatitis B dies,make an appointment with 750 thousand every year. Time hope from discovery HBV arrives vaccine of invention second liver, arrive again develop a variety of course that resist HBV medicaments, probably from which can derive force, drive the mankind to gain the victory that this rich weichis finally. Discover HBV: Already extensive instrument seeks laying? last centuries 40 time, british doctor F. O. MacCallum and his work in the same placing named the armour that travels through enteron hepatitis and the hepatitis B that travel through blood transfusion. But in ten years subsequently, a lot of research that seek pathogen seat ceaselessly are empty-handed. 1963, american Baruch S. The serum that Dr. Blumberg discovers a hemophiliac can produce reaction with the antigen in serum of an Australia native, those who say for Australian antigen (Aa, abbreviation bay fight ) . In the research of after this, blumberg assumes Australian antigen should be concerned with virus sex hepatitis. 1967-1968 year, blumberg and additionally a few scholars reported Aa participates in virus sex hepatitis formally at the same time almost come on. 1970, british scholar D. S. Dane observe below the electron microscope the grain of second liver virus in haemal sample, dane grain also is called after. Here, must mention Blumberg again -- the legend person that this concerns with second liver, he and bay fight discovery is concerned, the discovery with HBV is concerned, with second liver vaccinal invention still is concerned. This great learned man that there is outstanding contribution in hepatitis B research was obtained 1976 Nobel medicine and physiological award . Preparation HBV is vaccinal: Century of?0 of 　 of ァ of allow Piao  70 time end, the one part that Aa is compositive HBV grain gets a proof, name HBV surface antigen (HBsAg) . And in before this 10 years, blumberg and Professor Millman had begun to study preparation second liver is vaccinal. They use specific technology to part HBsAg and virus, undertake HBsAg decreasing living destroying poison, this is the vaccinal first course that make. Begin from 1971, the component that the scholar such as the Maurice Hilleman of institute of silent gram cure puts forward to use virus or inferior unit preparation vaccine is very important, and this theory preparation gives follow HBV inferior the unit is vaccinal. 1980, the person that the scholar such as the Wolf Szmuness of center of new York blood confirms this kind of vaccine has protective have an inoculation does not suffer the effect that HBV affects, businesslike amount to 90% , and without side-effect. It is to be in almost with HBV inferior while unit vaccine is developed, the scholars such as California university William Rutter put forward to use recombine vaccine of liver of technical preparation second, this kind of new technology can ensure vaccine does not get other virus pollution, still can be produced by large quantities of quantities. Came 1983 1986, microzyme recombines success of preparation of second liver vaccine, passed American FDA sanction 1986, apply extensively at have an inoculation of average crowd immunity. Be in China, began to execute have an inoculation of immunity of vaccine of infantile second liver to plan 1986, china brought into have an inoculation of second liver vaccine plan immunity management 1992, bring into plan immunity formally 2002, for all new students offer free vaccine, but not derate have an inoculation serves cost, give a new life completely 2005 free have an inoculation. Refuse HBV treatment: ∫ of 　 of  of the  that tell litter leans on Meng of plain Ω of acute communicable diseases of the word that show a bend to add fresh hole of locust of coerce of a surname dead Ai? of  of ≈ of crisp aim arm but in last centuries 90 time, the mankind realises disease-resistant poison treats ability is main treatment method, this should be second liver the important milestone on remedial history. Till at present, via American FDA approval, the curative owner that can use Yu Kang HBV should have two kinds: ? of bald model of fan Pan Gao is acerbity) analogue. Interferon from last centuries 50 time, alick Isaacs and Jean Lindenmann discovered interferon (IFN) , to the disease-resistant poison of IFN the mechanism is clarified, experienced more than 10 years. Subsequently, IFN begins to be used at treating hepatitis B, but till 80 time metaphase, α of IFN of project of the first gene - after 2a develops a success and appearing on the market, just by relatively apply at widely clinical. Go up century at the beginning of 80 time, swiss scientist and American scientist excogitate α of IFN of project of generation gene successfully at the same time almost. At the beginning of 1981, the synthesis such as Pestka is rarefied IFN α - 2a, get FDA approval enters clinical trial. 80 time metaphase, α of IFN of project of the 2nd acting gene - 2b comes out, its element structure and person IFN are almost consistent, was approved to be used at treating chronic hepatitis B by FDA 1986. Meanwhile, the scholar such as heart of cloud of our country Hou also is studying the preparation of gene project IFN. Of interferon get together glycol changes a technology to be in early 20 centuries 70 time are put forward, the half-life that aims to be able to lengthen interferon already can maintain its biology active again. At the beginning of this century, get together the clinical trial that glycol interferon enters hepatitis of remedial virus sex. 2005, get together glycol interferon α - 2a is approved through American FDA, use formally at second liver cure. Nucleotide (acerbity) analogue rummy husband is the earliest surely the nucleotide analogue that is used at treating AIDS by research and development, discover in using a process its can produce intense inhibition to HBV after, then investigator treats this medicine try out at chronic second liver. After 1995, Ⅱ period mixes the global much center that rummy husband treats hepatitis B surely clinical trial starts Ⅲ period early or late. 1998, american FDA approves rummy husband to be used at treating hepatitis B surely, this medicine serves as exclusive profess to convinced later fight HBV to use drug and be applied extensively, this kind of situation just is broken after 4 years. In September 2002, ester of A Defu Wei uses Yu Kang HBV to treat through American FDA approval, subsequently, favour the Wei He that replace card is replaced part to obtained American FDA to approve in October 2006 at was being mixed in March 2005 surely than the husband, among them, for be being decided than the husband is what be maintained by American FDA is exclusive medicaments of class of a gravid B. Approve at obtaining an European Union this year for Nuofuwei in its 27 members country appears on the market. Nucleotide (acerbity) analogue controls virus function with its strong, noxiousness low, be caused by is undesirable react light, profess to convinced is used convenient wait for an advantage, in clinical on get applied extensively. But only abiding restrain virus to duplicate, ability prevents the progress of hepatic pathological changes, because this asks nucleotide analogue is long-term,apply. As a result of the characteristic of HBV duplicate itself, analogue of long-term application nucleotide produces virus to be able to bear or endure medical mutation cannot avoid. Be able to bear or endure the medicaments curative effect that the occurrence of medical HBV will make sequel is treated is reduced, accordingly, should be able to bear or endure to virus medicine, it is current and the serious problem that future combats HBV to treat need to face. (the exercitation edits: Plum apricot)